Abstract
The X-ray fluorescence method (XRF) enables one to estimate total stable iodine pool (ITI) in the human thyroid gland in vivo with reasonable accuracy and without unreasonable radiation burden (1,2). Most of the ITI is stored in thyroglobulin (TG) (3). Iligher than normal serum thyroglobulin concentrations (sTG) have been found in various thyroid dysfunction and this has been related to enhanced release by the thyroid cell, as a result of thyrotropin stimulation (TSH) (4), of tissue lesion as in subacute thyroiditis or through an unknown mechanism such as in thyroid cancer (5). The aim of the present work was to assess whether high sTG could be related to ITI in euthyroid patients with simple goitre.
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References
Hoffer PB, Jones WB, Crawford RB, Gottschalk A, Fluorescent Thyroid Scanni a new method of imaging the thyroid. Radiology 90: 342, 1968.
Jonckheer MJ, Deconinck F, X-ray fluorescence determination of stable ioc in the thyroid gland. A review. Acta clin. belg. 1982 (In press).
DeGroot LJ, Stanburry JB, The thyroid and its diseases. John Wiley and Sor New York, 1975.
Unger J, Van Heuverswijn C, Decoster C, Cantraine F, Mockel J, Van Herle I Thyroglobulin and thyroid hormone release after intravenous administratior bovine thyrotropin in man. J. clin. Endocr. Metab. 51: 590, 1980.
Van Herle AJ, Vassart G, Dumont JE, Control of thyroglobulin synthesis anc secretion. New. Engl. J. Med. 301: 307, 1979.
Deconinck F, Medische toepassing van halfgeleidersdetectoren. Thesis V.U.1 Brussels, 1977.
Mandart G, Erbsman F, Estimation of thyroid weight by scintigraphy. Int. Nucl. Biol. 2: 185, 1975.
Van Herle AJ, Uller R.P. Matthews NC, Brown J, Radioimmunoassay for measum ment of thyroglobulin in human serum. J. clin. Invest. 62: 1320, 1973.
Snedecor GW, Statistical Methods, Iowa State University Press, Ames. 1956.
Wold H, Non linear estimation by iterative least squares procedures. In: Festschrift for J. David FN (ed), Weyman, Wiley, New York, 1966.
Ibbertson HK,,Endemic goitre and cretinism. Clin. Endocr. Metab. 8:100, 19
Pezzino V, Vigneri R, Squatrito S, Filetti S, Camus M, Polosa P, Increase(serum thyroglobulin levels in patients with nontoxic goitre. J. clin. End(Metab. 46: 653, 1978.
Van Herle AJ, Klandorf H, Uller RP, A radioimmunoassay for serum rat thyrc globulin: physiologic and pharmacologic studies. J. clin. Invest. 56: 1073, 1975.
Ermans AM, Kinthaert J, Camus M, Defective intrathyroidal iodine metaboli: in non-toxic goitre: inadequate iodination of thyroglobulin. J. clin. End Metab. 28:1307, 1968.
Jonckheer MJ, Vanhaelst L, Deconinck F, Michotte Y, Atrophic autoimmune thyroiditis. Relationship between the clinical state and intrathyroidal ioc as measured in vivo in man. J. clin. Endocr. Metab. 53: 476, 1981.
Shlossberg AH, Jacobson JC, Ibbertson HK, Serum thyroglobulin in the diagr and management of thyroid carcinoma. Clin. Endocr. 10: 17, 1979.
Torrigiani J, Doniach D, Roitt IM, Serum thyroglobuline levels in healthy subjects and in patients with thyroid disease. J. clin. Endocr. 29:305, 19
Lukas WP, Leisner B, Fink U, Seiderer M, Pickardt CR, Liisner J, Sonographische Volumebestimming der Schilddruse. Vergleich mit anderen Methoden. Nuklearmedizin 20: 64, 1981.
Reutsch H, Studer H, Frauchiger B, Siebenhuner L, Topographical heterogen(of basal and TSH stimulated adenyl cyclase activity in human nodular goit(J. clin. Endocr. 53: 507, 1981.
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© 1982 Martinus Nijhoff Publishers, The Hague
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Jonckheer, M.H., Unger, J., Coomans, D., Decoster, C. (1982). The Relationship between Serum Thyroglobulin and Intrathyroidal Stable Iodine in Euthyroid Goitrous Patients. In: Cox, P.H. (eds) Progress in Radiopharmacology 3. Developments in Nuclear Medicine, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7669-6_8
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DOI: https://doi.org/10.1007/978-94-009-7669-6_8
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