Measurement of Regional Cerebral Function for Neurological Research Using Positron Emission Tomography and Shortlived Cyclotron Produced Isotopes
Advances in the understanding of brain pathophysiology and the treatment of cerebral disorders are, in many respects, restricted by the development of associated technologies. This is illustrated by the paucity of reliable measurements of regional cerebral function which, until recently, have been limited to measurements of blood flow and of the general integrity of the blood brain barrier — using indicator dilution techniques and radioactive tracers. The restricted development of these techniques has been due to the virtual lack of spatial resolution of the various imaging devices in the depth plane and the limited choice of radio-actively labelled tracers.
KeywordsOxygen Extraction Fraction Isotope Concentration Oxygen Extraction Ratio Indicator Dilution Technique Regional Blood Volume
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