Measurement of Regional Cerebral Function for Neurological Research Using Positron Emission Tomography and Shortlived Cyclotron Produced Isotopes

  • C. G. Rhodes
Part of the Developments in Nuclear Medicine book series (DNUM, volume 2)


Advances in the understanding of brain pathophysiology and the treatment of cerebral disorders are, in many respects, restricted by the development of associated technologies. This is illustrated by the paucity of reliable measurements of regional cerebral function which, until recently, have been limited to measurements of blood flow and of the general integrity of the blood brain barrier — using indicator dilution techniques and radioactive tracers. The restricted development of these techniques has been due to the virtual lack of spatial resolution of the various imaging devices in the depth plane and the limited choice of radio-actively labelled tracers.


Oxygen Extraction Fraction Isotope Concentration Oxygen Extraction Ratio Indicator Dilution Technique Regional Blood Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Jones T, Chester DA, Ter-Pogossian MM. (1976): The continuata inhalation of oxygen-15 for assessing regional oxygen extraction in the brain of man. Br. J. Radiol. 49:339–343.PubMedCrossRefGoogle Scholar
  2. 2.
    Huang SC, Phelps ME, Hoffman EJ, Kuhl DE. (1979): A theoretical study of quantitative flow measurements with constant infusion of short-lived isotopE Phys. Med. Biol. 24:1151–1161.Google Scholar
  3. 3.
    Phelps ME, Mazziotta. JC, Huang SC. (1982): Study of cerebral function with positron computed tomography - Review. J. Cereb. Blood Flow Metab. 2: 113–162.PubMedCrossRefGoogle Scholar
  4. 4.
    West JB, Dollery CT. (1962): Uptake of oxygen-15 labelled CO compared with carbon-11 labelled CO2 in the lung. J. Appt. Physiol. 17:9–13.Google Scholar
  5. 5.
    Frackowiak RSJ, Lenzi GL, Jones T Heather JD. (1980): Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 150 and positron emission tomography: Theory, procedure and normal values. J. Comput Assist. Tomogr. 4:727–736.PubMedCrossRefGoogle Scholar
  6. 6.
    Rhodes CG, Lenzi GL, Frackowiak RSJ, Jones T, Pozzili C. (19811: Measurement of CBF and CMRO2 using the continuous inhalation of C15O2 and 502:Experimental validation using CO2 reactivity in the anaesthetised dog. J. Neurol. Sci. 50 381–389.Google Scholar
  7. 7.
    Baron JC, Steinling M, Tanaka T, Cavalheiro E, Soussaline F, Collard P. (1981): Quantitative measurement of CBF, oxygen extraction fraction (OEF) and CMRO2 with 1 0 continuous inhalation techniques and positron emission tomography (PET): Experimental evidence and normal values in man. J.Cereb. Blood Flow Metabol., 1(Supp1.1):55–56.Google Scholar
  8. 8.
    Lammertsma AA, Heather JD, Jones T, Frackowiak RSJ, Lenzi GL. (1982): A statistical study of the steady state techniqy for measuring regional cerebral blood flow and oxygen utilisation using O. J. Comput. Assist. Tomogr. 6(3):566–573.PubMedCrossRefGoogle Scholar
  9. 9.
    Lammertsma AA, Jones T, Frackowiak RSJ, Lenzi GL. (1981): A theoretical study of the steady state model for measuring regional cerebral blood flow and oxygen utilisation using oxygen-15. J. Comput Assist Tomogr. 5:544–550.PubMedCrossRefGoogle Scholar
  10. 10.
    Sokoloff L, Reivich M, Kennedy C, Des Rosiers MH, Patlak CS, Pettigrew KD, Sakurada KD, Sakurada 0.(1977): The (14C)-dexyglucose method for the measure ment of local cerebral glucose utilisation: Theory, procedure and normal values in the conscious and anesthetiscd rat. J. Neurochem. 28:897–916.PubMedCrossRefGoogle Scholar
  11. 11.
    Phelps ME, Huang SC, Hoffman EJ, Kuhl DE. (1979): Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18) 2-fluoro-2-deoxl D-glucose: Validation of method. Ann. Neurol. 6:371–388.PubMedCrossRefGoogle Scholar
  12. 12.
    Phelps ME, Huang SC, Hoffman EJ, Kuhl DE. (1979): Tomographic measurement of cerebral blood volume C-11 labelled carboxyhemoglobin. J. Nucl. Med.20:328–1PubMedGoogle Scholar
  13. 13.
    Cline MJ. (1975): The White Cell. Harvard University Press, pp.39–70, 479–4EGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers, The Hague 1982

Authors and Affiliations

  • C. G. Rhodes

There are no affiliations available

Personalised recommendations