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Radiohalogenated L-α-Methyltyrosines as Potential Pancreas Imaging Agents for PECT and SPECT

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Progress in Radiopharmacology 3

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 2))

Abstract

The diagnosis of pancreatic carcinoma is still a problem in nuclar medicine (1), and an improved pancreas imaging agent is urgently needed. Currently, L-I75Se)-seleno-methionine (SM) is used as an agent for the detection of pancreatic carcinoma (2), with 99mTc sulfur colloid often injected in addition in order to permit the substraction of the interfering liver back-ground from SM (3). This imaging procedure results in rather large radiation doses to the patient, especially since the biological half-time of SM (70 days) is comparable with the physical half-life (120 days) of 75Se (4). Additionally, significant numbers of false-positives and false-negatives make routine diagnosis difficult (5).

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Authors
  1. G. Kloster
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  2. H. H. Coenen
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  3. Z. Szabo
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  4. F. Ritzl
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  5. G. Stöcklin
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Editor information

Editors and Affiliations

  1. Rotterdamsch Radio-Therapeutisch Instituut, Netherlands

    Peter H. Cox (Head Department of Nuclear Medicine, Co-ordinating Chairman Joint Committee on Radiopharmaceuticals of the Society of Nuclear Medicine and the European Nuclear Medicine Society) (Head Department of Nuclear Medicine, Co-ordinating Chairman Joint Committee on Radiopharmaceuticals of the Society of Nuclear Medicine and the European Nuclear Medicine Society)

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© 1982 Martinus Nijhoff Publishers, The Hague

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Kloster, G., Coenen, H.H., Szabo, Z., Ritzl, F., Stöcklin, G. (1982). Radiohalogenated L-α-Methyltyrosines as Potential Pancreas Imaging Agents for PECT and SPECT. In: Cox, P.H. (eds) Progress in Radiopharmacology 3. Developments in Nuclear Medicine, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7669-6_12

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  • DOI: https://doi.org/10.1007/978-94-009-7669-6_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-7671-9

  • Online ISBN: 978-94-009-7669-6

  • eBook Packages: Springer Book Archive

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