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Clinical Significance of Chromosome Abnormalities in Childhood and Adult Leukemia

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Pancreatic Tumors in Children

Part of the book series: Cancer Treatment and Research ((CTAR,volume 8))

Abstract

Our knowledge of chromosome patterns in human leukemia has progressed remarkably since the advent of banding techniques, which permit the precise identification of each human chromosome and of parts of chromosomes as well. First, the nature of the Ph1 chromosome in chronic myelogenous leukemia (CML) and the occurrence of nonrandom abnormalities in addition to the Ph1 chromosome in the blastic phase of CML were established. Second, specific chromosome abnormalities in acute nonlymphocytic leukemia (ANLL) were identified; these changes were found to be closely related to certain clinical features and also to the morphology of the leukemic cells. More recently, nonrandom abnormalities in acute lymphoblastic leukemia (ALL) have been established, and their correlation with the clinical features of the disease has been clarified. We will review chromosome abnormalities that occur in leukemia, with emphasis on their clinical significance, and then we will delineate the similarities and the differences in the chromosome patterns observed in adult and childhood leukemia.

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Authors
  1. Yasuhiko Kaneko
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  2. Janet D. Rowley
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Editor information

Editors and Affiliations

  1. Department of Pediatrics, Hematology-Oncology, Oklahoma Children’s Memorial Hospital, University of Oklahoma Health Sciences Center, P.O. Box 26307, 73126, Oklahoma City, OK, USA

    G. Bennett Humphrey M.D., Ph.D.

  2. Department M-305, Lilly Research Laboratories, 307 E. McCarty Street, 46285, Indianapolis, IN, USA

    Gerald B. Grindey

  3. Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Mayo Memorial Building, Box 609, 55455, Minneapolis, MN, USA

    Louis P. Dehner

  4. Department of Microbiology & Public Health, University of Alabama in Birmingham, University Station, 35294, Birmingham, AL, USA

    Ronald T. Acton Ph.D.

  5. Department of Pathology, Oklahoma Children’s Memorial Hospital, University of Oklahoma Health Sciences Center, P.O. Box 26307, 73126, Oklahoma City, OK, USA

    Theodore T. Pysher

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© 1982 Martinus Nijhoff Publishers, The Hague

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Kaneko, Y., Rowley, J.D. (1982). Clinical Significance of Chromosome Abnormalities in Childhood and Adult Leukemia. In: Humphrey, G.B., Grindey, G.B., Dehner, L.P., Acton, R.T., Pysher, T.T. (eds) Pancreatic Tumors in Children. Cancer Treatment and Research, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7615-3_4

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  • DOI: https://doi.org/10.1007/978-94-009-7615-3_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-7617-7

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