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Clonal Evolution and Childhood Tumors

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Pancreatic Tumors in Children

Part of the book series: Cancer Treatment and Research ((CTAR,volume 8))

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Abstract

Many of the clinical and biological characteristics of tumor development appear to fit with the view that most neoplasms are unicellular in origin (i.e., ‘clones’) and that tumor progression results from ‘clonal evolution’, the sequential appearance within unstable neoplastic clones of subpopulations which are more and more genetically aberrant. These concepts, and the suggested underlying mechanisms, will be reviewed briefly, along with some of the supporting evidence. Although relatively few data are available from tumors occurring in the pediatric age group, some examples from both hematopoietic and nonhematopoietic neoplasms will be summarized. The findings support the general applicability of these concepts to pediatric neoplasms, but certain special characteristics of this age group require consideration, and these will be discussed from the standpoint of both their theoretical and practical implications.

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References

  1. Hamden D: The relationship between induced chromosome aberrations and chromosome abnormality in tumor cells. In Human Genetics, Armendares S, Lisker R (eds). Amsterdam: Excerpta Medica, 1977, pp 355–366.

    Google Scholar 

  2. Nowell P: Cytogenetics. In: Cancer: A Comprehensive Treatise, Vol I, Etiology, Becker F (ed). New York: Plenum, 1982, pp 3–46.

    Google Scholar 

  3. Fialkow P: Clonal origin of human tumors. Ann Rev Med 30: 135–143, 1979.

    Article  PubMed  CAS  Google Scholar 

  4. Heppner GH, Shapiro WR, Rankin JK: Tumor heterogeneity. In: Pediatric Oncology, Vol 1, Humphrey GB, Dehner LP, Grindey GB, Acton RT (eds). The Hague: Martinus Nijhoff, 1981, pp 99–116.

    Google Scholar 

  5. Linder D, Gartler SM: Glocuse-6-phosphate dehydrogenase mosaicism: utilization as a cell marker in the study of leiomyomas. Science 150: 67–69, 1965.

    Article  PubMed  CAS  Google Scholar 

  6. Friedman JM, Fialkow P: Viral tumorigenesis’ in man: cell markers in condylomata acuminata. Int J Cancer 17: 57–61, 1976.

    Article  PubMed  CAS  Google Scholar 

  7. Knudson AG: Mutation and cancer: statistical study of retinoblastoma. Proc Nat Acad Sci USA 68: 820–823, 1971.

    Article  PubMed  Google Scholar 

  8. Knudson A, Meadows A, Nichols W, Hill R: Chromosomal deletion and retinoblastoma. N Eng J Med 295: 1120–1123, 1976.

    Article  Google Scholar 

  9. Cairns J: Mutation, selection, and the natural history of cancer. Nature 255: 197–200, 1975.

    Article  PubMed  CAS  Google Scholar 

  10. De Grouchy J, De Nava C: A chromosomal theory of carcinogenesis. Ann Int Med 69: 381–391, 1968.

    PubMed  Google Scholar 

  11. Klein G: Lymphoma development in mice and humans: diversity of initiation is followed by convergent cytogenetic evolution. Proc Natl Acad Sci USA 76: 2442–2446, 1979.

    Article  PubMed  CAS  Google Scholar 

  12. Makino S: Further evidence favoring the concept of the stem cell in ascites tumors of rats. Ann NY Acad Sci 64: 818–823, 1956.

    Article  Google Scholar 

  13. Nowell P: The clonal evolution of tumor cell populations. Science 194: 23–28, 1976.

    Article  PubMed  CAS  Google Scholar 

  14. Rowley JD: Chromosome abnormalities in cancer. Cancer Genet and Cytogenet 2: 175–198, 1980.

    Article  Google Scholar 

  15. Rowley JD: Ph-positive leukemia, including chronic myelogenous leukemia. Clinics in Haematol 9: 55–86, 1980.

    CAS  Google Scholar 

  16. Fialkow P, Denman A, Jacobson R, Leventhal M: Chronic leukemia: origin of some lymphocytes from leukemic stem cells. J Clin Invest 62: 815–822, 1978.

    Article  PubMed  CAS  Google Scholar 

  17. Nowell P, Finan J, Glover D, Guerry D: Cytogenetic evidence for the clonal nature of Richter’s syndrome. Blood 58: 183–186, 1981.

    PubMed  CAS  Google Scholar 

  18. Mark J: Rous sarcoma in mice: the chromosomal progression in primary tumors. Eur J Cancer 5: 307–318, 1969.

    Google Scholar 

  19. Mitelman F: The chromosomes of fifty primary Rous rat sarcomas. Hereditas 69: 155–162, 1971.

    Article  PubMed  CAS  Google Scholar 

  20. Boveri T: In: Zur Frage der Entstehung maligner Tumoren. Jenai Gustav Fischer Verlag, 1914.

    Google Scholar 

  21. Von Hansemann D: Über asymmetrische Zellteilung in Epithelkrebsen and deren biologische Bedeutung. Virchow Arch Pathol Anat Physiol 119: 298–307, 1890.

    Google Scholar 

  22. Oksala T, Therman E: Mitotic abnormalities and cancer. In: Chromosomes and Cancer, German J (ed). New York: Wiley, 1974, pp 239–263.

    Google Scholar 

  23. Danes BS: Increased in vitrotetraploidy: tissue specific within the heritable colorectal cancer syndromes with polyposis coli. Cancer 41: 2330–2334, 1978.

    Article  PubMed  CAS  Google Scholar 

  24. Otter M, Palmer C, Baehner R: Elevated sister chromatid exchange rate in childhood lymphoblastic leukemia. Proc Am Assoc Cancer Res 19: 202, 1978.

    Google Scholar 

  25. Parshad R, Sanford KK, Tarone RE, Jones GM, Baeck AE: Increased susceptibility of mouse cells to fluorescent light-induced chromosome damage after long-term culture and malignant transformation. Cancer Res 39: 929–933, 1979.

    PubMed  CAS  Google Scholar 

  26. Shiraishi Y, Sandberg AA: Effects of various chemical agents on sister chromatid exchanges, chromosome aberrations, and DNA repair in normal and abnormal human lymphoid cells. J Natl Cancer Inst 62: 27–33, 1979.

    PubMed  CAS  Google Scholar 

  27. Sokova O, Volgareva G, Pogosiantz H: Effect of fluorafur on chromosomes of normal and malignant Djungarian hamster cells. Genetika 12: 156–159, 1976.

    PubMed  CAS  Google Scholar 

  28. Weiner F, Dalianis T, Klein G, Harris H: Cytogenetic studies on the mechanism of formation of isoantigenic variants in somatic cell hybrids. J Natl Cancer Inst 52: 1779–1785, 1974.

    Google Scholar 

  29. German J: The association of chromosome instability, defective DNA repair, and cancer in some rare human genetic diseases. In: Human Genetics, Armendares S, Lisker R (eds). Amsterdam: Excerpta Medica, 1977, pp 64–68.

    Google Scholar 

  30. Hecht F, McCaw B: Chromosome instability syndromes. Prog Cancer Res Ther 3: 105–123, 1977.

    Google Scholar 

  31. Setlow R: Repair deficient human disorders and cancer. Nature 271: 713–717, 1978.

    Article  PubMed  CAS  Google Scholar 

  32. Li FP, Potter NU, Buchanan GR, Vawter G, Whang-Peng J, Rosen RB: A family with acute leukemia, hypoplastic anemia, and cerebellar ataxia: association with bone marrow C-monosomy. Am J Med 65: 933–939, 1978.

    Article  PubMed  CAS  Google Scholar 

  33. Nowell P: Preleukemia: cytogenetic clues in some confusing disorders. Am J Pathol 89: 459–476, 1977.

    PubMed  CAS  Google Scholar 

  34. Seabright M: Patterns of induced aberrations in humans with abnormal autosomal complements. Chrom Today 5: 293–297, 1976.

    Google Scholar 

  35. Law IP, Hollinshead AC, Whang-Peng J, Dean JH, Oldham RK, Herberman RB, Rhode MC: Familial occurrence of colon and uterine carcinoma and of lymphoproliferative malignancies. Cancer 39: 1229–1236, 1977.

    Article  PubMed  CAS  Google Scholar 

  36. Miller OJ, Breg WR, Schmickel RD, Tretter W: A family with an XXXXY male, a leukemic male, and two 21 trisomie mongoloid females. Lancet ii: 78–79, 1961.

    Article  Google Scholar 

  37. Heston L: Alzheimer’s disease, trisomy 21, and myeloproliferative disorders: associations suggesting a genetic diathesis. Science 196: 322–323, 1977.

    Article  PubMed  CAS  Google Scholar 

  38. Loeb L, Battula N, Springgate C, Seal G: On mutagenic DNA polymerase and malignancy. In: Fundamental Aspects of Malignancy. Berlin: Springer, 1975, pp 243–246.

    Google Scholar 

  39. Hecht F, Kaiser McCaw B: Position effects in 8; 14 translocation in Burkitt’s lymphoma. N Eng J Med 304: 174–175, 1981.

    CAS  Google Scholar 

  40. McClintock B: The origin and behavior of mutable loci in maize. Proc Natl Acad Sci USA 36: 344–355, 1950.

    Article  PubMed  CAS  Google Scholar 

  41. Sager R: Transposable elements and chromosomal rearrangements in cancer: a possible link. Nature 282: 447–448, 1979.

    Article  PubMed  CAS  Google Scholar 

  42. Biedler JL, Spengler BA: Metaphase chromosome anomaly: association with drug resistance and cell-specific products. Science 191: 185–187, 1976.

    Article  PubMed  CAS  Google Scholar 

  43. Balaban-Malenbaum G, Gilbert F: Double minute chromosomes and the homogeneously staining regions in chromosomes on a human neuroblastoma cell line. Science 198: 739–742, 1978.

    Article  Google Scholar 

  44. Passarge E, Bartram C: Somatic recombination as possible prelude to malignant transformation. In: Birth Defects: Original Article Series. New York: The National Foundation, 1976, pp 177–180.

    Google Scholar 

  45. Turleau C, Cabanis MO, De Grouchy J: Augmentation des échanges de chromatides dans les fibroblasts d’un enfant atteint de del(13)-rétinoblastome. Annales de Génétique 23: 169170, 1980.

    Google Scholar 

  46. Cairns J: The origin of human cancers. Nature 289: 353–357, 1981.

    Article  PubMed  CAS  Google Scholar 

  47. Temin H: The DNA provirus hypothesis. Science 192: 1075–1080, 1976.

    Article  PubMed  CAS  Google Scholar 

  48. Whang-Peng J, Knutsen T, Ziegler J, Leventhal B: Cytogenetic studies in acute lymphocytic leukemia: special emphasis in long-term survival. Med Pediatr Oncol 2: 333–351, 1976.

    Article  PubMed  CAS  Google Scholar 

  49. Benedict W, Lange M, Greene J, Derencsenyi A, Alfi O: Correlation between prognosis and bone marrow chromosomal patterns in children with acute nonlymphocytic leukemia: similarities and differences compared to adults. Blood 54: 818–823, 1979.

    PubMed  CAS  Google Scholar 

  50. Hecht F, McCaw B: Chromosome instability syndromes. Prog Cancer Res Ther 3: 105–123, 1977.

    Google Scholar 

  51. Levitt R, Pierre R, White W, Sickert R: Atypical lymphoid leukemia in ataxia-telangiectasia. Blood 52: 1003–1011, 1978.

    PubMed  CAS  Google Scholar 

  52. Saxon A, Stevens R, Golde D: Helper and suppressor T-lymphocyte leukemia in ataxia telangiectasia. N Eng J Med 300: 700–704, 1979.

    Article  CAS  Google Scholar 

  53. Nowell P, Shankey T, Finan J, Guerry D, Beas E: Proliferation, differentiation, and cytogenetics of chronic leukemic B lymphocytes cultured with motimycin-treated normal cells. Blood 57: 444–451, 1981.

    PubMed  CAS  Google Scholar 

  54. Prindull G, Jentsch E, Hansmann I: Fanconi’s anaemia developing erythroleukemia. Scand J Haematol 23: 59–63, 1979.

    Article  PubMed  CAS  Google Scholar 

  55. Berenblum I: Sequential aspects of chemical carcinogenesis in skin. In: Cancer: A Comprehensive Treatise, Becker FF (ed). New York: Plenum Press, 1975, pp 323–344.

    Google Scholar 

  56. Farber E, Cameron C: The sequential analysis of cancer development. Adv Cancer Res 31: 125–225, 1980.

    Article  PubMed  CAS  Google Scholar 

  57. Orye E, Delbeke MJ: Clonal evolution in solid tumors in children. Oncol 29: 520–533, 1974.

    Article  CAS  Google Scholar 

  58. Balaban-Malenbaum G, Gilbert F: The proposed origin of double minutes from homogeneously staining region (HSR) marker chromosomes in human neuroblastoma hybrid cell lines. Cancer Gen and Cytogen 2: 339–348, 1980.

    Article  Google Scholar 

  59. Balaban-Malenbaum G, Gilbert F: unpublished.

    Google Scholar 

  60. Yunis JJ, Ramsay N: Retinoblastoma and subband deletion of chromosome 13. Am J Dis Child 132: 161–163, 1978.

    PubMed  CAS  Google Scholar 

  61. Yunis JJ, Ramsay N: Retinoblastoma and subband deletion of chromosome 13. Am J Dis Child 132: 161–163, 1978.

    PubMed  CAS  Google Scholar 

  62. Balaban-Malenbaum G, Gilbert F, Nichols W: Abnormalities in chromosome 13 in direct preparations from human retinoblastoma. Am J Human Gen 32: 62A, 1980.

    Google Scholar 

  63. Riccardi V, Sujansky E, Smith A, Francke U: Chromosomal imbalance in the aniridiaWilms’ tumor association: 11p interstitial deletion. Pediatrics 61: 604–610, 1978.

    PubMed  CAS  Google Scholar 

  64. Braun AC: The Cancer Problem. New York: Columbia University Press, 1969.

    Google Scholar 

  65. Di Berardino MA, King TJ: Transplantation of nuclei from the frog renal adenocarcinoma. II. Chromosomal and histologic analysis of tumor nuclear transplant embryos. Develop Biol 11: 217–222, 1965.

    Article  Google Scholar 

  66. Mintz B: Genetic mosaicism and in vivoanalyses of neoplasia and differentiation. Ann Symp Cancer Res 30: 27–53, 1978.

    Google Scholar 

  67. O’Hara M: Teratomas, neoplasia, and differentiation: a biological overview. I. The natural history of teratomas. Invest Cell Pathol 1: 39–63, 1978.

    Google Scholar 

  68. Kolber AR, Goldstein MN, Moore BW: Effect of nerve growth factor on the expression of colchicine–binding activity and 14–3–2 protein in an established line of human neuroblastoma. Proc Natl Acad Sci USA 71: 4203 – 4207, 1974.

    Article  PubMed  CAS  Google Scholar 

  69. Mintz B, Illmensee K: Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proc Natl Acad Sci USA 72: 3585–3589, 1975.

    Article  PubMed  CAS  Google Scholar 

  70. Meadows AT, Strong LC, Li SP, D’Angio DJ, Schweisguth O, Freeman AI, Jenkin RDT, Morris-Jones P, Nesbit ME: Bone sarcoma as a second malignant neoplasm in children: influence of radiation and genetic disposition. Cancer 46: 603–606, 1980.

    Article  Google Scholar 

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Authors
  1. Peter C. Nowell
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  2. Gloria B. Balaban
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Editor information

Editors and Affiliations

  1. Department of Pediatrics, Hematology-Oncology, Oklahoma Children’s Memorial Hospital, University of Oklahoma Health Sciences Center, P.O. Box 26307, 73126, Oklahoma City, OK, USA

    G. Bennett Humphrey M.D., Ph.D.

  2. Department M-305, Lilly Research Laboratories, 307 E. McCarty Street, 46285, Indianapolis, IN, USA

    Gerald B. Grindey

  3. Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Mayo Memorial Building, Box 609, 55455, Minneapolis, MN, USA

    Louis P. Dehner

  4. Department of Microbiology & Public Health, University of Alabama in Birmingham, University Station, 35294, Birmingham, AL, USA

    Ronald T. Acton Ph.D.

  5. Department of Pathology, Oklahoma Children’s Memorial Hospital, University of Oklahoma Health Sciences Center, P.O. Box 26307, 73126, Oklahoma City, OK, USA

    Theodore T. Pysher

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© 1982 Martinus Nijhoff Publishers, The Hague

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Nowell, P.C., Balaban, G.B. (1982). Clonal Evolution and Childhood Tumors. In: Humphrey, G.B., Grindey, G.B., Dehner, L.P., Acton, R.T., Pysher, T.T. (eds) Pancreatic Tumors in Children. Cancer Treatment and Research, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7615-3_2

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  • DOI: https://doi.org/10.1007/978-94-009-7615-3_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-7617-7

  • Online ISBN: 978-94-009-7615-3

  • eBook Packages: Springer Book Archive

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