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Pancreatic Tumors in Children pp 3–24Cite as

Role of Natural Killer (NK) Cells in Resistance to Tumors

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 8))

Abstract

Studies on natural cell-mediated cytotoxicity began as a rather restricted effort, to understand a puzzling series of observations that were made during investigations of cell-mediated cytotoxicity in tumor-bearing or in individuals immunized against tumors. The expected finding was specific cytotoxic activity against autologous tumor cells or against tumors of the same histologic or etiologic type. It was assumed in the initial studies that lymphoid cells from normal individuals would be unreactive and thus would serve as good baseline controls for comparison. Indeed, mice or rats immunized against various tumors, especially those induced by type C oncorna-viruses, were found to have increased cytotoxic reactivity against the immunizing tumor or against tumor cells sharing the relevant tumor-associated antigens [1–4]. Similarly, a considerable proportion of patients with various types of cancer appeared to selectively react against cell lines derived from tumors of the same organ or of the same histologic type [4, 5].

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Authors
  1. Ronald B. Herberman
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Editors and Affiliations

  1. Department of Pediatrics, Hematology-Oncology, Oklahoma Children’s Memorial Hospital, University of Oklahoma Health Sciences Center, P.O. Box 26307, 73126, Oklahoma City, OK, USA

    G. Bennett Humphrey M.D., Ph.D.

  2. Department M-305, Lilly Research Laboratories, 307 E. McCarty Street, 46285, Indianapolis, IN, USA

    Gerald B. Grindey

  3. Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Mayo Memorial Building, Box 609, 55455, Minneapolis, MN, USA

    Louis P. Dehner

  4. Department of Microbiology & Public Health, University of Alabama in Birmingham, University Station, 35294, Birmingham, AL, USA

    Ronald T. Acton Ph.D.

  5. Department of Pathology, Oklahoma Children’s Memorial Hospital, University of Oklahoma Health Sciences Center, P.O. Box 26307, 73126, Oklahoma City, OK, USA

    Theodore T. Pysher

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© 1982 Martinus Nijhoff Publishers, The Hague

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Herberman, R.B. (1982). Role of Natural Killer (NK) Cells in Resistance to Tumors. In: Humphrey, G.B., Grindey, G.B., Dehner, L.P., Acton, R.T., Pysher, T.T. (eds) Pancreatic Tumors in Children. Cancer Treatment and Research, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7615-3_1

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  • DOI: https://doi.org/10.1007/978-94-009-7615-3_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-7617-7

  • Online ISBN: 978-94-009-7615-3

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