Flow Behavior of White Blood Cells in Vitro and in Vivo (Commentary)
The papers of this Symposium provide sufficient information on the properties of individual WBC, rheology of suspensions containing WBC, and mechanisms of WBC margination to describe the main features of flow of WBC in venules and arterioles. The viscoelastic properties of granulocytes and lymphocytes reported by La Celle et al. and other papers of this Symposium make it clear that WBC are generally sufficiently stiffer than erythrocytes so that in a suspension of normal proportions the WBC must behave essentially as rigid spheres. This is borne out by the bulk rheological measurements of leukocytes suspensions by Cokelet and Lichtman. In fact in relatively pure leukocyte suspensions the data for high shear rates shows that the apparent viscosity is higher for WBC suspensions than for smooth, hard sphere suspensions. As these authors suggest this probably reflects the effect of roughness of the WBC surface.
KeywordsApparent Viscosity High Shear Rate Rigid Sphere Pathological Situation Erythrocyte Aggregation
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