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The Evaluation of Beta Blocker and Calcium Antagonist Drugs pp 313–328Cite as

The Electrophysiologic Differences of Calcium Antagonist Drugs

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 18))

Abstract

In 1967, FLECKENSTEIN et al (27) assumed that the new compounds prenylamine and verapamil were inhibitors of the action of calcium. The concept that these so-called Ca-antagonists are inhibitors of the slow channel, is now widely accepted (16, 46, 61, 88, 100). These drugs are affecting structures in which impulse propagation is mediated by the slow channel, i.e. the sinus and A-V node. In addition, they may depress action potentials and slow conduction in diseased myocardial or Purkinje fibers. As a consequence, SINGH and VAUGHAN WILLIAMS (90) postulated a new class of antiarrhythmic action (class 4). However, some recent investigations have questioned this uniform concept for all Ca-antagonists (3, 15, 21, 28, 42, 48, 61, 62, 88). In the following paper the electrophysio-logic differences will be discussed with regard to experimental and clinical studies.

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  1. L. Seipel
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Editors and Affiliations

  1. The Lankenau Medical Research Center, Jefferson Medical College of The Thomas Jefferson University, Philadelphia, PA, USA

    Joel Morganroth M.D.

  2. School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA

    E. Neil Moore D. V. M., Ph.D.

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Seipel, L., Breithardt, G. (1982). The Electrophysiologic Differences of Calcium Antagonist Drugs. In: Morganroth, J., Moore, E.N. (eds) The Evaluation of Beta Blocker and Calcium Antagonist Drugs. Developments in Cardiovascular Medicine, vol 18. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7561-3_26

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