Abstract
The body of published data on which opinions can be based concerning the part played by heredity in inflammatory bowel disease is of very mixed value. No family investigation has been carried out including sigmoidoscopy of all relatives. In few studies has there been physical examination of the relatives or even questioning of each of the relatives. In many the family data has been based merely on the history given by the patients, and it can be assumed that such studies greatly underestimate the number of patients who have one or more relatives who also have inflammatory bowel disease.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Asquith P, Mackintosh P, Stokes PL, Holmes GKT, Cooke WT. 1974. Histocompatibility antigens in patients with inflammatory bowel disease. Lancet 1: 113–115.
Biemond I, Weterman IT, van Rood JJ, Klasen P, Khan M, Pe$a AS. 1981. Search for genetic markers associated with Crohn’s disease in the Netherlands. In: Pena AS, Weterman IT, Booth CC, Strober W. (eds). Recent advances in Crohn’s disease, Martinus Nijhoff, The Hague. p. 197–203.
Burnham WR, Gelsthorpe K, Langman MJS. 1981. HLA-D related antigens in inflammatory bowel disease. In: Pena AS, Weterman IT, Booth CC and Strober W. (eds). Recent advances in Crohn’s disease, Martinus Nijhoff, The Hague. p 192–6.
Cohen Z, McCulloch P, Leung MK, Mervart H. 1981. Histocompatibility antigens in patients with Crohn’s disease. In: Pena AS, Weterman IT, Booth CC and Strober W. (eds). Recent advances in Crohn’s disease, Martinus Nijhoff, The Hague. p 186–191.
Cowan WK. 1973. Genetics of duodenal and gastric ulcer. Clinics in Gastroenterology 2: 539–546.
Delpre G, Kadish ü, Gazit E, Joshua H, Zamir R. 1980. HLA antigens in ulcerative colitis and Crohn’s disease in Israel. Gastroenterology 78: 1452–1457.
Finery AEH, Lawrence JS. 1967. Genetics of ankylosing spondylitis. Journal of Medical Genetics 4: 239–244.
Farmer RG, Michener WM, Mortimer EA. 1980. Studies of family history among patients with inflammatory bowel disease. Clinics in Gastroenterology 9: 271–277.
Gleeson MH, Walker JS, Wentzel J, Chapman JA, Harris R. 1972. Human leucocyte antigens in Crohn’s disease and ulcerative colitis. Gut 13: 438–440.
Haslock I, Macrae, IF, Wright V. 1974. Arthritis and intestinal diseases; a comparison of two family studies. Rheumatology and Rehabilitation 13: 135–40.
Jayson MIV, Salmon PR, Harrison WJ. 1970. Inflammatory bowel disease in ankylosing spondylitis. Gut 11: 506–511.
Kemler BJ, Glass D, Alpert E. 1980. HLA studies of families with multiple cases of inflammatory bowel disease ( IBD ). Gastroenterology 78: 1194.
Kirsner JB. 1973. Genetic aspects of inflammatory bowel disease. Clinics in Gastroenterology 2: 557–575.
Klein GL, Ament ME, Sparkes RS. 1980. Monozygotic Twins with Crohn’s disease: a case report. Gastroenterology 79: 931–933.
Korelitz BI. 1981. Epidemiological evidence for a hereditary component in Crohn’s disease. In Pesa AS, Weterman IT, Booth CC and Strober W. (eds). Recent advances in Crohn’s disease, Martinus Nijhoff, The Hague. p. 209–212.
Lewkonia RM, McConnell RB. 1976. Familial inflammatory bowel disease–heredity or environment? Gut 17: 235–243.
Lewkonia RM, Woodrow JC, McConnell RB, Evans DAP. 1974. HL-A antigens in inflammatory bowel disease. Lancet 1: 574–575.
McBride JA, King MJ, Baikie AG, Crean GP, Sircus W. 1963. Ankylosing spondylitis and chronic inflammatory diseases of the intestines. British Medical Journal 2: 483–486.
McConnell RB. 1966. The Genetics of Gastrointestinal Disorders. Oxford University Press, London.
McConnell RB. 1980. Inflammatory bowel disease: newer views of genetic influence. In: Berk JE. (ed). Developments in Digestive Diseases, Lea and Febiger, Philadelphia. Chap. 7. p. 129–137.
Macrae I, Wright V. 1973. A family study of ulcerative colitis: with particular reference to ankylosing spondylitis and sacroiliitis. Annals of Rheumatic Diseases 32: 16–20.
Mayberry JF, Rhodes J, Newcombe RG. 1980. Familial prevalence of inflammatory bowel disease in relatives of patients with Crohn’s disease. British Medical Journal 1: 84.
Morichau-Beauchant M, Matuchansky C, Dofing JL, Yver L, MorichauBeauchant J. 1977. Entérite regionale chez des jumeaux homozygotes. Revue de la littérature â propos du 11e cas rapporté. Gastroenterologie Clinique et Biologique 1: 783–788.
Pena AS. 1980. Immunogenetic aspects of inflammatory bowel disease. In: Rotter JI, Samloff IM, Rimoin DL. (eds). Genetics and heterogeneity of common gastrointestinal disorders, Academic Press, New York. p. 281–289.
Thorsby E, Lie SO. 1971. Relationship between the HL-A system and susceptibility to diseases. Transplant proceedings 3: 1305–1307.
Tsuchiya M, Yoshida T, Asakura H, Hibi T, Ono A. 1977. HLA antigens and ulcerative colitis in Japan. Digestion 15: 286–294.
Whorwell PJ, Bade OE, Hossenbocus A, Bamforth J. 1978. Crohn’s disease in a husband and wife. Lancet 2: 186–187.
Woodrow JC, Lewkonia RM, McConnell RB, Berg-Loonen EMVD, Meuwissen SGM, Dekker-Saeys BJ, Nijenhuis LE, Mowbray JF, Johnson N McI. 1978. HLA antigens in inflammatory bowel disease. Tissue Antigens 11: 147–152.
Zetzel L. 1978. Crohn’s disease in a husband and wife. Lancet 2: 583.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Martinus Nijhoff Publishers, The Hague
About this chapter
Cite this chapter
McConnell, R.B. (1982). Genetics and Inflammatory Bowel Disease. In: Rachmilewitz, D. (eds) Inflammatory Bowel Diseases. Developments in Gastroenterology, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7514-9_13
Download citation
DOI: https://doi.org/10.1007/978-94-009-7514-9_13
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-7516-3
Online ISBN: 978-94-009-7514-9
eBook Packages: Springer Book Archive