Abstract
Favism is used to describe a hemolytic syndrone in susceptible individuals after eating seeds of Vicia faba. It is characterised most often by weakness or fatigue, pallor, jaundice and hemoglobinuria. In hospitalised patients, large amounts of hemoglobin in the urine persists for 1–3 days. Small amounts of oxyhemoglobin and methemoglobin are also found in the urine, which appears dark brown, red or even black. Death may occur from renal failure (1). In severe cases, erythrocyte counts are markedly reduced and blood transfusions are necessary.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Belsey, M.A. 1973. The epidemiology of favism. Bull. Wld. Hlth. Org. 48: 1–13.
Beutler, E. 1978. Hemolytic anemia in desorders of red cell metabolism. Plenum Medical Book Co., N.Y.
Bottini, E., Lucarelli, P., Agostino, R., Palmarino, R., Businco, I., Antognoni, G. 1971. Favism: Association with erythrocyte acid phosphatase phenotype. Science 171: 409–411.
Carcassi, U.E.F. 1974. The interaction between B-thalassemia, G-6PD deficiency and favism. Ann. N.Y. Academy Sci. 232: 297–305.
Cassimos, C., Malaka-Zafiriu, K. Tsiures, J., Danielides, B. 1974a. Variation in salicylamide glucuronide formation in normal and G-6PD-deficient children. J. Pediatr. 84: 110–111.
Cassimos, C., Malaka-Zafiriu, K., Tsiures, J. 1974b. Urinary D-glucaric acid excretion in normal and G-6-PD-deficient children with favism. J. Pediatr. 84: 871–872.
Collier, H.B., Aherne, F.X., Kennelly, J.J. 1978. Effects of faba bean diet on growth, liver weight, and non-protein thiol levels of erthrocytes and liver in weanling rats. Can. J. Anim. Sci. 58: 531–532.
Corash, L. Spielberg, S., Bartsocas, C., Boxer, L., Steinherz, R., Sheetz, M., Egan, M., Schlessleman, J., Schulman, J.D. 1980. Reduced chronic hemolysis during high-dose vitamin E administration in Mediterranean-type glucose-6-phosphate dehydrogenase deficiency. New England J. Med. 303: 416–420.
Crosby, W.H. 1956. Favism in Sardinia. Blood 1 1: 91–92.
Dacie, J.V. 1967. The haemolytic anaemia. Second ed., part IV, Churchhill, London, pp. 1061–1077.
D’Aquino, M., Gaetani, S., Spadoni, M.A. 1979. A search for an animal model to assay the factor of favism. Nutrition Reports Inter. 20: 1–9.
Flohe, L., Neibch, G., Reiber, H. 1971, The effect of divicine on human erythrocytes. Z. Kiln. Biochem. 9: 431–437.
Gaetani, G.F., Mareni, C., Salvidio, E., Galiano, S., Meloni, T., Arise, P. 1979. Favism: Erthrocyte metabolism during haemolytic and reticulocytosis. British J. Haem. 43: 39–48.
Haidas, S., Zannos-Mariolea, L., Matsaniotis, N. 1975. Red cell 2, 3-diphosphoglycerate levels in children with hereditary haemolytic anaemias. British J. Haem. 31: 521–530.
Kattamis, C.A., Kyriazakou, M., Chaidas, S. 1969. Favism. Clinical and biochemical data. J. Med. Gent. 6: 34–41.
Lin, J.Y. Ling, K.H. 1962a. Studies on favism 2. Studies on the physiological activities of vicine in vitro. J. Formosan Med. Assoc. 61: 490–494.
Lin, J.Y., Ling, K.H. 1962b. Studies on favism. 3. Studies on the physiological activities of vicine in vitro. J. Formosan Med. Assoc. 61: 579–583.
Mager, J., Glaser, G., Razin, A., Izak, G., Bien, S., Noam, M. 1965. Metabolic effects of pyrimidines derived from faba bean glycosides on human erythrocytes deficient in glycose 6-phosphate dehydrogenase. Biochem. Biophys. Res. Comm. 20: 235–240.
Mager, J., Razin, A., Hershko, A. 1969. In: E. Liener (ed.), Toxic constiutents of plant foodstuffs. Academic Press, N.Y. pp 293–318.
Marquardt, R.R., Frohlich, A. 1981. A rapid reverse-phase high-performance liquid chromatographic method for the quantitation of vicine, convicine and related products. J. Chromat. 208: 373–379
Meloni, T., Pilo, G., Gallisai, D., Dare, A. 1979. Serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, gamma-glutamyl transpeptidase and glutamic dehydrogenase levels in favism. Acta. Haemat. 62: 71–73.
Muduuli, D.S. 1980. The quantitative isolation of vicine from faba bean protein concentrate and the involvement of free radicals in the biophysiochemical effects of vicine in the chicken. Ph.D. Thesis, Dept. of Anim. Sci., Univ. of Manitoba, Winnipeg, Canada R3T 2N2.
Muduuli, D.S., Marquardt, R.R., Guenter, W. 1981. Effect of dietary vicine on the production performance of laving chickens. Can. J. Anim. Sci. 61: 757–764.
Olaboro, G., Marquardt, K.R., Campbell, L.D. 1981. Isolation of the egg weight depressing factor in faba beans (Vicia faba L. var. minor). J. Sci. Food Agric. 32: 1074–80.
Palmarino, R., Agostino, R., Gloria, F., Lucarelli, P., Businco, L. Antognoni, G., Maggioni, G., Workman, P.L., Bottini, E. 1975. Red cell acid phosphatase: Another polymorphism correlated with malaria. Am. J. Phys. Anthrop. 43: 177–186.
Stamatoyannopoulos, G., Fraser, G.R., Motulsky, A.G., Fessa, Ph., Akrivakis, A., Papayannopoulou, Th. 1966. On the familial predisposition to favism. Am. J. Hum. Gen. 18: 253–263.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 ICARDA
About this chapter
Cite this chapter
Marquardt, R.R. (1982). Favism. In: Hawtin, G., Webb, C. (eds) Faba Bean Improvement. World Crops: Production, Utilization, and Description, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7499-9_36
Download citation
DOI: https://doi.org/10.1007/978-94-009-7499-9_36
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-7501-9
Online ISBN: 978-94-009-7499-9
eBook Packages: Springer Book Archive