• Ronald R. Marquardt
Part of the World Crops: Production, Utilization, and Description book series (WCPU, volume 6)


Favism is used to describe a hemolytic syndrone in susceptible individuals after eating seeds of Vicia faba. It is characterised most often by weakness or fatigue, pallor, jaundice and hemoglobinuria. In hospitalised patients, large amounts of hemoglobin in the urine persists for 1–3 days. Small amounts of oxyhemoglobin and methemoglobin are also found in the urine, which appears dark brown, red or even black. Death may occur from renal failure (1). In severe cases, erythrocyte counts are markedly reduced and blood transfusions are necessary.


Faba Bean G6PD Deficiency G6PD Activity Amino Pyrimidine Chronic Hemolysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Belsey, M.A. 1973. The epidemiology of favism. Bull. Wld. Hlth. Org. 48: 1–13.Google Scholar
  2. 2.
    Beutler, E. 1978. Hemolytic anemia in desorders of red cell metabolism. Plenum Medical Book Co., N.Y.Google Scholar
  3. 3.
    Bottini, E., Lucarelli, P., Agostino, R., Palmarino, R., Businco, I., Antognoni, G. 1971. Favism: Association with erythrocyte acid phosphatase phenotype. Science 171: 409–411.PubMedCrossRefGoogle Scholar
  4. 4.
    Carcassi, U.E.F. 1974. The interaction between B-thalassemia, G-6PD deficiency and favism. Ann. N.Y. Academy Sci. 232: 297–305.CrossRefGoogle Scholar
  5. 5.
    Cassimos, C., Malaka-Zafiriu, K. Tsiures, J., Danielides, B. 1974a. Variation in salicylamide glucuronide formation in normal and G-6PD-deficient children. J. Pediatr. 84: 110–111.CrossRefGoogle Scholar
  6. 6.
    Cassimos, C., Malaka-Zafiriu, K., Tsiures, J. 1974b. Urinary D-glucaric acid excretion in normal and G-6-PD-deficient children with favism. J. Pediatr. 84: 871–872.CrossRefGoogle Scholar
  7. 7.
    Collier, H.B., Aherne, F.X., Kennelly, J.J. 1978. Effects of faba bean diet on growth, liver weight, and non-protein thiol levels of erthrocytes and liver in weanling rats. Can. J. Anim. Sci. 58: 531–532.Google Scholar
  8. 8.
    Corash, L. Spielberg, S., Bartsocas, C., Boxer, L., Steinherz, R., Sheetz, M., Egan, M., Schlessleman, J., Schulman, J.D. 1980. Reduced chronic hemolysis during high-dose vitamin E administration in Mediterranean-type glucose-6-phosphate dehydrogenase deficiency. New England J. Med. 303: 416–420.CrossRefGoogle Scholar
  9. 9.
    Crosby, W.H. 1956. Favism in Sardinia. Blood 1 1: 91–92.Google Scholar
  10. 10.
    Dacie, J.V. 1967. The haemolytic anaemia. Second ed., part IV, Churchhill, London, pp. 1061–1077.Google Scholar
  11. 11.
    D’Aquino, M., Gaetani, S., Spadoni, M.A. 1979. A search for an animal model to assay the factor of favism. Nutrition Reports Inter. 20: 1–9.Google Scholar
  12. 12.
    Flohe, L., Neibch, G., Reiber, H. 1971, The effect of divicine on human erythrocytes. Z. Kiln. Biochem. 9: 431–437.Google Scholar
  13. 13.
    Gaetani, G.F., Mareni, C., Salvidio, E., Galiano, S., Meloni, T., Arise, P. 1979. Favism: Erthrocyte metabolism during haemolytic and reticulocytosis. British J. Haem. 43: 39–48.CrossRefGoogle Scholar
  14. 14.
    Haidas, S., Zannos-Mariolea, L., Matsaniotis, N. 1975. Red cell 2, 3-diphosphoglycerate levels in children with hereditary haemolytic anaemias. British J. Haem. 31: 521–530.CrossRefGoogle Scholar
  15. 15.
    Kattamis, C.A., Kyriazakou, M., Chaidas, S. 1969. Favism. Clinical and biochemical data. J. Med. Gent. 6: 34–41.CrossRefGoogle Scholar
  16. 16.
    Lin, J.Y. Ling, K.H. 1962a. Studies on favism 2. Studies on the physiological activities of vicine in vitro. J. Formosan Med. Assoc. 61: 490–494.Google Scholar
  17. 17.
    Lin, J.Y., Ling, K.H. 1962b. Studies on favism. 3. Studies on the physiological activities of vicine in vitro. J. Formosan Med. Assoc. 61: 579–583.Google Scholar
  18. 18.
    Mager, J., Glaser, G., Razin, A., Izak, G., Bien, S., Noam, M. 1965. Metabolic effects of pyrimidines derived from faba bean glycosides on human erythrocytes deficient in glycose 6-phosphate dehydrogenase. Biochem. Biophys. Res. Comm. 20: 235–240.PubMedCrossRefGoogle Scholar
  19. 19.
    Mager, J., Razin, A., Hershko, A. 1969. In: E. Liener (ed.), Toxic constiutents of plant foodstuffs. Academic Press, N.Y. pp 293–318.Google Scholar
  20. 20.
    Marquardt, R.R., Frohlich, A. 1981. A rapid reverse-phase high-performance liquid chromatographic method for the quantitation of vicine, convicine and related products. J. Chromat. 208: 373–379CrossRefGoogle Scholar
  21. 21.
    Meloni, T., Pilo, G., Gallisai, D., Dare, A. 1979. Serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, gamma-glutamyl transpeptidase and glutamic dehydrogenase levels in favism. Acta. Haemat. 62: 71–73.PubMedCrossRefGoogle Scholar
  22. 22.
    Muduuli, D.S. 1980. The quantitative isolation of vicine from faba bean protein concentrate and the involvement of free radicals in the biophysiochemical effects of vicine in the chicken. Ph.D. Thesis, Dept. of Anim. Sci., Univ. of Manitoba, Winnipeg, Canada R3T 2N2.Google Scholar
  23. 23.
    Muduuli, D.S., Marquardt, R.R., Guenter, W. 1981. Effect of dietary vicine on the production performance of laving chickens. Can. J. Anim. Sci. 61: 757–764.CrossRefGoogle Scholar
  24. 24.
    Olaboro, G., Marquardt, K.R., Campbell, L.D. 1981. Isolation of the egg weight depressing factor in faba beans (Vicia faba L. var. minor). J. Sci. Food Agric. 32: 1074–80.CrossRefGoogle Scholar
  25. 25.
    Palmarino, R., Agostino, R., Gloria, F., Lucarelli, P., Businco, L. Antognoni, G., Maggioni, G., Workman, P.L., Bottini, E. 1975. Red cell acid phosphatase: Another polymorphism correlated with malaria. Am. J. Phys. Anthrop. 43: 177–186.PubMedCrossRefGoogle Scholar
  26. 26.
    Stamatoyannopoulos, G., Fraser, G.R., Motulsky, A.G., Fessa, Ph., Akrivakis, A., Papayannopoulou, Th. 1966. On the familial predisposition to favism. Am. J. Hum. Gen. 18: 253–263.Google Scholar

Copyright information

© ICARDA 1982

Authors and Affiliations

  • Ronald R. Marquardt
    • 1
  1. 1.Department of Animal ScienceUniversity of ManitobaWinnipegCanada

Personalised recommendations