Favism is used to describe a hemolytic syndrone in susceptible individuals after eating seeds of Vicia faba. It is characterised most often by weakness or fatigue, pallor, jaundice and hemoglobinuria. In hospitalised patients, large amounts of hemoglobin in the urine persists for 1–3 days. Small amounts of oxyhemoglobin and methemoglobin are also found in the urine, which appears dark brown, red or even black. Death may occur from renal failure (1). In severe cases, erythrocyte counts are markedly reduced and blood transfusions are necessary.
KeywordsFaba Bean G6PD Deficiency G6PD Activity Amino Pyrimidine Chronic Hemolysis
Unable to display preview. Download preview PDF.
- 1.Belsey, M.A. 1973. The epidemiology of favism. Bull. Wld. Hlth. Org. 48: 1–13.Google Scholar
- 2.Beutler, E. 1978. Hemolytic anemia in desorders of red cell metabolism. Plenum Medical Book Co., N.Y.Google Scholar
- 7.Collier, H.B., Aherne, F.X., Kennelly, J.J. 1978. Effects of faba bean diet on growth, liver weight, and non-protein thiol levels of erthrocytes and liver in weanling rats. Can. J. Anim. Sci. 58: 531–532.Google Scholar
- 8.Corash, L. Spielberg, S., Bartsocas, C., Boxer, L., Steinherz, R., Sheetz, M., Egan, M., Schlessleman, J., Schulman, J.D. 1980. Reduced chronic hemolysis during high-dose vitamin E administration in Mediterranean-type glucose-6-phosphate dehydrogenase deficiency. New England J. Med. 303: 416–420.CrossRefGoogle Scholar
- 9.Crosby, W.H. 1956. Favism in Sardinia. Blood 1 1: 91–92.Google Scholar
- 10.Dacie, J.V. 1967. The haemolytic anaemia. Second ed., part IV, Churchhill, London, pp. 1061–1077.Google Scholar
- 11.D’Aquino, M., Gaetani, S., Spadoni, M.A. 1979. A search for an animal model to assay the factor of favism. Nutrition Reports Inter. 20: 1–9.Google Scholar
- 12.Flohe, L., Neibch, G., Reiber, H. 1971, The effect of divicine on human erythrocytes. Z. Kiln. Biochem. 9: 431–437.Google Scholar
- 16.Lin, J.Y. Ling, K.H. 1962a. Studies on favism 2. Studies on the physiological activities of vicine in vitro. J. Formosan Med. Assoc. 61: 490–494.Google Scholar
- 17.Lin, J.Y., Ling, K.H. 1962b. Studies on favism. 3. Studies on the physiological activities of vicine in vitro. J. Formosan Med. Assoc. 61: 579–583.Google Scholar
- 19.Mager, J., Razin, A., Hershko, A. 1969. In: E. Liener (ed.), Toxic constiutents of plant foodstuffs. Academic Press, N.Y. pp 293–318.Google Scholar
- 22.Muduuli, D.S. 1980. The quantitative isolation of vicine from faba bean protein concentrate and the involvement of free radicals in the biophysiochemical effects of vicine in the chicken. Ph.D. Thesis, Dept. of Anim. Sci., Univ. of Manitoba, Winnipeg, Canada R3T 2N2.Google Scholar
- 26.Stamatoyannopoulos, G., Fraser, G.R., Motulsky, A.G., Fessa, Ph., Akrivakis, A., Papayannopoulou, Th. 1966. On the familial predisposition to favism. Am. J. Hum. Gen. 18: 253–263.Google Scholar