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Morphology of the Basement Membrane in Carcinoma of the Cervix

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Carcinoma of the Cervix

Part of the book series: Developments in Obstetrics and Gynecology ((DIOG,volume 6))

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Abstract

Basement membranes are found wherever plasma membranes of parenchymal cells come into contact with connective tissue elements as seen by electron microscopy (Vracko 1974). Opinions about the existence of a basement membrane in cervical epithelium have previously been rather controversial (Ashworth et al. 1961). Ever since the basement membrane in this tissue had been demonstrated to exist, it has attracted considerable attention; particularly because of the unsettled question of the role which is played by the basement membrane in the transition of carcinoma in situ in to invasive carcinoma. The determination of the invasive status of cervical carcinoma depends, to a large extent, on the structural integrity of the basement membrane underlying the neoplastic epithelium (Coppleson 1976). Most investigators of cervical neoplasma have focused on the absence or presence of the basement membrane rather than on its morphology in different conditions such as dysplasia, carcinoma in situ and invasive carcinoma.

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References

  • Ashworth CT, Stembridge VA, Luibel FJ: A study of basement membranes of normal epithelium, carcinoma in situ and in vasive carcinoma of uterine cervix utilizing electron microscopy and histochemical methods. Acta cytologica 5: 331, 1961.

    Google Scholar 

  • Auersperg N, Erber H, Worth A: Histologic variation among poorly differentiated invasive carcinomas of human uterine cervix. J Natl Cancer Inst 51: 1461, 1973.

    PubMed  CAS  Google Scholar 

  • Burghardt E: Workshop session: Histological terminology. In Burghardt E, Holzer E, Jordan JA (eds): Cervical pathology and colposcopy. Stuttgart: G. Thieme Publishers, 1978.

    Google Scholar 

  • Coppleson M: Management of preclinical carcinoma of the cervix. In Jordan JA, Singer A (eds): The Cervix. Philadelphia: Saunders Company Ltd, 1976, pp 453–474.

    Google Scholar 

  • Farquhar M: Role of the basement membrane in glomerula filtration: Results obtained with electron-dense tracers. In Mausnbach AB, Olsen TS, Christensen EI (eds): Functional ultrastructure of the kidney. New York: Academic Press, 1980, pp 31–51.

    Google Scholar 

  • Hay ED, Dodson JW: Secretion of collagen by corneal epithelium I. Morphology of collagenous products produced by isolated epithelia grown on frozen-killed lens. J Cell Biol 57: 190, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Kefalides NA, Alper R, Clark CC: Biochemistry and metabolism of basement membranes. Int Rev Cytol 61: 167, 1979.

    Article  PubMed  CAS  Google Scholar 

  • Kocher O, Amaudruz M, Schindler AM, Gabbiani G: Desmosomes and gap junctions in precarcinomatous and carcinomatous conditions of squamous epithelia. J Submicr Cytol 13: 267, 1981.

    CAS  Google Scholar 

  • Langley FA: The pathology of cervical neoplasia. In Jordan JA, Singer A (eds): The Cervix. Philadelphia: Saunders Company Ltd 1976, pp 345–363.

    Google Scholar 

  • Luibel FJ, Sanders E, Ashworth CT: An electron microscopic study of carcinoma in situ and invasive carcinoma of the cervix uteri. Cancer Res 20: 357, 1960.

    PubMed  CAS  Google Scholar 

  • Price RG, Spiro RG: Studies on the metabolism of the renal glomerular basement membrane. J Biol Chem 23: 8597, 1977.

    Google Scholar 

  • Shingleton HM, Lawrence DW: Transmission electron microscopy of cervical neoplasia. In Jordan JA, Singer E (eds): The Cervix. Philadelphia: Saunders Company Ltd, 1976, pp 363–371.

    Google Scholar 

  • Twiggs LB, Okagaki T, Clark BA: Progressive loss of basal cell pseudopodia in cervical intraepithelial neoplasia. An example of inhibition of differentiation in vivo. Presented at the symposium: Carcinoma of the cervix. Charleston, SC, 1980.

    Google Scholar 

  • Vracko R: Basal lamina scaffold: Anatomy and significance for maintenance of orderly tissue structure. Am J Pathology 77: 314, 1974.

    CAS  Google Scholar 

  • Younes MS: Electron microscope observations on carcinoma in situ of the cervix. Obstetr Gynecol Survey 24: 768, 1968.

    Article  Google Scholar 

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© 1982 Martinus Nijhoff Publishers, The Hague

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Spornitz, U.M., Hafez, E.S.E. (1982). Morphology of the Basement Membrane in Carcinoma of the Cervix. In: Hafez, E.S.E., Smith, J.P. (eds) Carcinoma of the Cervix. Developments in Obstetrics and Gynecology, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7485-2_18

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  • DOI: https://doi.org/10.1007/978-94-009-7485-2_18

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-7487-6

  • Online ISBN: 978-94-009-7485-2

  • eBook Packages: Springer Book Archive

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