General Strategy of Antihypertensive Treatment

  • F. Olaf Simpson
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 16)


The general strategy of antihypertensive treatment has to be considered under two headings. Firstly, there is the strategy for dealing with hypertension as a national problem, i.e. on a population basis, and secondly the strategy for dealing with hypertension in the individual patient.


High Blood Pressure Plasma Renin Activity Antihypertensive Therapy Antihypertensive Treatment Sodium Intake 
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  1. 1.
    Page IH: The continuing failure to understand and treat hypertension. JAMA 241: 1897–1898, 1979.PubMedCrossRefGoogle Scholar
  2. 2.
    Editorial. Lowering blood pressure without drugs. Lancet 2: 459–461, 1980.Google Scholar
  3. 3.
    Arterial hypertension. Report of a WHO Expert Committee. WHO, Geneva, 1978.Google Scholar
  4. 4.
    Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. A cooperative study. JAMA 237: 255–261, 1977.CrossRefGoogle Scholar
  5. 5.
    The 1980 report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. Arch Intern Med 140: 1280–1285, 1980.CrossRefGoogle Scholar
  6. 6.
    Simpson FO: Hypertension. BR Med J 2: 882–883, 1978.PubMedCrossRefGoogle Scholar
  7. 7.
    Hypertension Detection and Follow-up Program Cooperative Group: Five-Year findings on the hypertension detection and follow-up program — I. Reduction in mortality of persons with high blood pressure, including mild hypertension. JAMA 242: 2562–2571, 1979.CrossRefGoogle Scholar
  8. 8.
    Hypertension Detection and Follow-up Program Cooperative Group: Five-year findings of the hypertension detection and follow-up program, — II. Mortality by race, sex and age. JAMA 242: 2572–2577, 1979.CrossRefGoogle Scholar
  9. 9.
    Management Committee Report: The Australian therapeutic trial in mild hypertension. Lancet 1: 1261–1267, 1980.Google Scholar
  10. 10.
    Editorial. Mild hypertension. Br Med J 280: 1062–1063, 1980.CrossRefGoogle Scholar
  11. 11.
    Tudor Hart J: The management of high blood pressure in general practice. JR Coll Gen Pract 25: 160–192, 1975.Google Scholar
  12. 12.
    Coope J: A screening clinic for hypertension in general practice. JR Coll Gen Pract 24: 161–166, 1974.Google Scholar
  13. 13.
    Heller RF, Rose G: Current management of hypertension in general practice. Br Med J 1: 1442–1444, 1977.PubMedCrossRefGoogle Scholar
  14. 14.
    Barber JH, Beevers DG, Fife R et al.: Blood-pressure screening and supervision in general practice. Br Med J 1: 843–846, 1979.PubMedCrossRefGoogle Scholar
  15. 15.
    Berkson DM, Brown MC, Stanton H et al.: Changing trends in hypertension detection and control: the Chicago experience. Am J Public Health 70: 389–393, 1980.PubMedCrossRefGoogle Scholar
  16. 16.
    Tuomilehto J, Nissinen A, Salonen JT, Kottke TE, Puska P: Community programme for control of hypertension in North Karelia, Finland. Lancet 2: 900–903, 1980.PubMedCrossRefGoogle Scholar
  17. 17.
    Haynes RB, Sackett DL, Taylor DW, Gibson ES, Johnson AL: Increased absenteeism from work after detection and labeling of hypertensive patients. N Engl J Med 299: 741–744, 1978.PubMedCrossRefGoogle Scholar
  18. 18.
    Thorn PA, Russell RG: Diabetic clinics today and tomorrow: mini-clinics in general practice. Br Med J 2: 534–536, 1973.PubMedCrossRefGoogle Scholar
  19. 19.
    Simpson FO: Long-term follow-up of elderly subjects on antihypertensive therapy. In: Hypertension in the Young and Old, pp. 331–334. Onesti G, Kim KE, eds. New York: Grune & Stratton, 1981.Google Scholar
  20. 20.
    Amery A, Berthaux P, Birkenhäger W et al.: Antihypertensive therapy in patients above age 60 years (Fourth Interim Report of the European Working Party on High Blood Pressure in Elderly: EWPHE). Clin Sci Mol Med 55: 263s–270s, 1978.Google Scholar
  21. 21.
    Simpson FO, Waal-Manning HJ, Bolli P, Spears GFS. A community study of risk factors for high blood pressure: possibilities for prevention. In: Prophylactic Approach to Hypertensive Diseases, pp. 31–39. Yamori Y et al., eds. New York: Raven Press, 1979.Google Scholar
  22. 22.
    Bloxham CA, Beevers DG, Walker JM: Malignant hypertension and cigarette smoking. Br Med J 1: 581–583, 1979.PubMedCrossRefGoogle Scholar
  23. 23.
    Isles C, Brown JJ, Cumming AMM et al.: Excess smoking in malignant-phase hypertension. Br Med J 1: 579–581, 1979.PubMedCrossRefGoogle Scholar
  24. 24.
    Elliott JM, Simpson FO: Cigarettes and accelerated hypertension. NZ Med J 91: 447–449, 1980.Google Scholar
  25. 25.
    Kannel WB, McGee D, Gordon T: A general cardiovascular risk profile: the Framingham study. Am J Cardiol 38: 46–51, 1976.PubMedCrossRefGoogle Scholar
  26. 26.
    Hunt JC. Management and treatment of essential hypertension. In: Hypertension, physiopathology and treatment, pp. 1068–1085. Genest J, Koiw E, Kuchel O, eds. New York: McGraw-Hill, 1977.Google Scholar
  27. 27.
    Simpson FO: Salt and hypertension: a sceptical review of the evidence. Clin Sci 57: 463s–480s, 1979.PubMedGoogle Scholar
  28. 28.
    Parfrey PS, Vandenburg MJ, Wright P et al.: Blood pressure and hormonal changes following alteration in dietary sodium and potassium in mild essential hypertension. Lancet 1: 59–63, 1981.PubMedCrossRefGoogle Scholar
  29. 29.
    Carney S, Morgan T, Wilson M, Matthews G, Roberts R: Sodium restriction and thiazide diuretics in the treatment of hypertension. Med J Aust 1: 803–807, 1975.PubMedGoogle Scholar
  30. 30.
    Shah S, Khatri I, Freis ED: Mechanism of antihypertensive effect of thiazide diuretics. Am Heart J 95: 611–618, 1978.PubMedCrossRefGoogle Scholar
  31. 31.
    Schroeder HA: Control of hypertension by hexamethonium and 1-hydrazinophthalazine. Arch Intern Med 89: 523–540, 1952.Google Scholar
  32. 32.
    Smirk FH: Drug therapy in hypertension. Clin Pharmacol Ther 2: 110–120, 1961.Google Scholar
  33. 33.
    Simpson FO: Principles of drug treatment for hypertension: indications for treatment and for selection of drugs. Pharmacol Ther 7: 153–172, 1979.PubMedCrossRefGoogle Scholar
  34. 34.
    Simpson FO: Hypertensive disease. In: Drug Treatment, pp. 639–682. Avery GS, ed. Sydney: ADIS Press, 1980.Google Scholar
  35. 35.
    Koch-Weser J: Individualization of antihypertensive treatment, pp.251–255. Clinical Pharmacology and Therapeutics, Turner P, ed. Proceed 1st World Conf, London: MacMillan, 1980.Google Scholar
  36. 36.
    Zanchetti A. Rational approaches to clinical therapy, pp. 270–274. Clinical Pharmacology and Therapeutics, Turner P, ed. Proceed 1st World Conf, London: MacMillan, 1980.Google Scholar
  37. 37.
    Kaplan NM, Kern DC, Holland OB et al.: The intravenous furosemide test: a simple way to evaluate renin responsiveness. Ann Intern Med 84: 639–645, 1976.PubMedGoogle Scholar
  38. 38.
    Laragh JH: Modern system for treating high blood pressure based on renin profiling and vasoconstriction-volume analysis: a primary role for beta blocking drugs such as propranolol. Am J Med 61: 797–810, 1976.PubMedCrossRefGoogle Scholar
  39. 39.
    Lund-Johansen P: Hemodynamic alterations in hypertension — spontaneous changes and effects of drug therapy. A review. Acta Med Scand (Suppl) 603: 1–14, 1977.Google Scholar
  40. 40.
    Laragh JH: Vasoconstriction-volume analysis for understanding and treating hypertension: the use of renin and aldosterone profiles. Am J Med 55: 261–274, 1973.PubMedCrossRefGoogle Scholar
  41. 41.
    Schalekamp MA, Lebel M, Beevers DG et al.: Body-fluid volume in low-renin hypertension. Lancet 2: 310–311, 1974.PubMedCrossRefGoogle Scholar
  42. 42.
    Schalekamp MADH, Birkenhäger WH, Zaal GA, Kolsters G: Haemodynamic characteristics of low-renin hypertension. Clin Sci Mol Med 52: 405–412, 1977.PubMedGoogle Scholar
  43. 43.
    Dunn MJ, Tannen RL: Low renin essential hypertension. In: Hypertension, Physiopathology and Treatment, pp. 349–364. Genest J, Koiw E, Kuchel O, Eds, New York: McGraw-Hill, 1977.Google Scholar

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© Martinus Nijhoff Publishers, The Hague 1982

Authors and Affiliations

  • F. Olaf Simpson

There are no affiliations available

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