Early Identification of Potentially Cured Patients with Acute Myelogenous Leukemia — A Recent Challenge

  • Michael J. Keating
Part of the Cancer Treatment and Research book series (CTAR, volume 5)


Historically, the treatment of adults with acute myelogenous leukemia (AML) has evolved through a number of phases. In the initial phase we saw the accumulation of information on the natural history of acute leukemia and study of the patterns of survival [1, 2]. Analysis of survival data in patients with acute leukemia who were treated with supportive care only was adequately documented and showed that half of all patients would die in less than four months and less than one patient in ten would live for one year. The early literature was concerned with documentation of spontaneous remissions, and up until 1960, there was no evidence that chemotherapy-induced remissions were of longer duration [1, 2] than those which occurred spontaneously. In addition, no accurate estimate of the response rate to chemotherapeutic agents was available, despite the fact that the ‘chemotherapy era’ in acute leukemia had been ushered in by Farber in 1949 [4].


Acute Leukemia Acute Myelogenous Leukemia Cytosine Arabinoside Acute Myeloblastic Leukemia Remission Induction 
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© Martinus Nijhoff Publishers bv, The Hague 1982

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  • Michael J. Keating

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