Mineralocorticoids and sodium transport

  • R. Fraser


Such is the wealth of information available on the mechanisms of action of hormones at the molecular level that it is easy to forget that most, if not all, of it has been gleaned during the last 20 years. It now seems clear that although some hormones may exert direct effects on cell metabolism, most seem to influence it by one of two mechanisms: by modifying protein synthesis by an effect on the cell nucleus1,2 or by stimulating the formation of a second messenger, a cyclic nucleotide usually cyclic adenosine monophosphate3. The aim of this chapter is to summarize the actions of the mineralocorticoid hormones, particularly aldosterone, on renal electrolyte metabolism, first summarizing the process of sodium transport in the distal convoluted tubule and then attempting to dissect the primary effects of aldosterone.


Sodium Transport Distal Convoluted Tubule Sodium Pump Inherit Disease Toad Urinary Bladder 
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© The Society for the Study of Inborn Errors of Metabolism 1981

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  • R. Fraser

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