Some regulatory principles in epithelial transport
This symposium takes place as I am about to leave the Max-Planck-Institute for Biophysics after 13 years of stimulating and rewarding research. Looking through the work done during this period by myself and in collaboration with my colleagues, it becomes evident that almost all of the studies have been linked, more or less closely, to the question of regulatory principles in epithelial transport. In rereading these papers, it is interesting to note how they reflect the change in emphasis that was placed for a long time on the metabolic events occurring in the intracellular compartment to the emphasis that is placed nowadays on the events occurring at the barrier between the extra- and intracellular compartment, the cell membrane. Therefore in this chapter I would like to develop, taking my own work as guideline, some general aspects of regulation of transport. This is not intended to be a complete review; its main intent is to provide a framework of concepts concerning the basic principles of epithelial transport and the sites and selectivity of its regulation that might be useful for studies of transport phenomena in health and disease.
KeywordsSugar Permeability Lactate Fractionation Pyruvate
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