Effects of fractionated doses of X-irradiation on the mechanical properties of skin: A long-term study
The most common skin tumours are basal-cell epitheliomas. A cure rate of over 90% has been obtained by both surgery and radiotherapy. As these tumours occur most often on the face, the acceptability of treatment must depend not only on cure but also on the cosmetic effect obtained. Radiotherapy is often used to treat the more extensive lesions and those occurring in the older age group. Many irradiation fractionation regimens are in use. The factors which influence the choice of regimen are convenience to the patient, size and depth of the lesion, proximity to radiosensitive organs, and traditional and economic considerations. Little attempt has been made to compare the cosmetic effect of differing regimens, although this is clearly an important factor especially in younger patients. Besides cure, therefore, the most important considerations are the effect of the radiation on the normal tissue and the success with which the radiation injury is repaired. The cosmetic effect varies not only with dose, time and the number of fractions but also with the pigmentation of the patient’s skin, the initial degree of atrophy and the site -face skin giving a relatively better cosmetic result than body skin. If depigmentation is pronounced the cosmetic result will appear worse in summer.
KeywordsHydration Fractionation Thymidine Dial Harness
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