Determination in vivo of water concentration profile in human stratum corneum by a photoacoustic method
The purpose of this study was to examine the use of photoacoustic spectroscopy for measuring the concentration profile of water in human stratum corneum in vivo. Stratum corneum is normally ‘dry’ at its surface and ‘wet’ at its base where it is in contact with the moist part of the epidermis. The concentration of water at the surface of the skin, the depth profile of water within the stratum corneum, and the overall water content of stratum corneum vary with the condition of the skin and the relative humidity of the ambient air. Changes in hydration of the stratum corneum are known to affect plasticity, conductivity, and diffusion of substances into the skin.
KeywordsWater Concentration Stratum Corneum Photoacoustic Spectroscopy Photoacoustic Signal Photoacoustic Cell
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