Skip to main content
SpringerLink
Log in

Drug Nucleic Acid Interactions: Proflavine Intercalation into Double-Helical Fragments of RNA and DNA

  • Conference paper
Nucleic Acids: The Vectors of Life

Part of the book series: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ((JSQC,volume 16))

  • 279 Accesses

Abstract

The results of crystallographic studies on proflavine complexed with three different dinucleoside phosphate systems, are discussed in terms of backbone and sugar conformations. Extent of drug-base-pair stacking and base-pair mutual orientations are compared and contrasted.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lerman, L.S: 1961, J. Mol. Biol. 3, pp. 18–30.

    Article  CAS  Google Scholar 

  2. Li, H.J. and Crothers, D.M.: 1969, J. Mol. Biol. 39, pp. 461–477.

    Article  CAS  Google Scholar 

  3. Patel, D.J. and Canuel, L.L.: 1977, Proc. Natl. Acad. Sci. USA 74, pp. 2624–2628.

    Article  CAS  Google Scholar 

  4. Broyde, S. and Hingerty, B.: 1979, Biopolymers 18, pp. 2905–2910.

    Article  CAS  Google Scholar 

  5. Kollman, P.A., Weiner, P.K. and Dearing, A.: 1981, Ann. N.Y. Acad. Sci. 367, pp. 250–268.

    Article  CAS  Google Scholar 

  6. Pritchard, N.J., Blake, A. and Peacocke, A.R.: 1966, Nature 212, pp. 1360–1361.

    Article  CAS  Google Scholar 

  7. Neidle, S., Achari, A., Taylor, G.L., Berman, H.M., Carrell, H.L., Glusker, J.P. and Stallings, W.C.: 1977, Nature 269, pp. 304–307.

    Article  CAS  Google Scholar 

  8. Berman, H.M., Stallings, W., Carrell, H.L., Glusker, J.P., Neidle, S., Taylor, G. and Achari, A.: 1979, Biopolymers 18, pp. 2405–2429.

    Article  CAS  Google Scholar 

  9. Shieh, H.-S., Berman, H.M., Dabrow, M. and Neidle, S.: 1980, Nucleic Acids Res. 8, pp. 85–97.

    Article  CAS  Google Scholar 

  10. Reddy, B.S., Seshadri, T.P., Sakore, T.D. and Sobell, H.M.: 1979, J. Mol. Biol. 138, pp. 787–812.

    Article  Google Scholar 

  11. Agggarwal, A., Islam, S.A., Kuroda, R. and Neidle, S.: 1983, J. Mol. Biol. submitted for publication.

    Google Scholar 

  12. Westhof, E. and Sundaralingam, M.: 1980, Proc. Natl. Acad. Sci. USA 77, pp. 1852–1956.

    Article  CAS  Google Scholar 

  13. Westhof, E., Rao, S.T. and Sundaralingam, M.: 1980, J. Mol. Biol. 142, pp. 331–361.

    Article  CAS  Google Scholar 

  14. Neidle, S., Taylor, G., Sanderson, M., Shieh, H.-S. and Berman, H.M.: 1978, Nucleic Acids Res. 2, pp. 4417–4422.

    Article  Google Scholar 

  15. Shieh, H.-S., Berman, H.M., Neidle, S., Taylor, G. and Sanderson, M.: 1982, Acta. Crystallogr. B38, pp. 523–531.

    Article  Google Scholar 

  16. Jain, S.C., Tsai, C.-C. and Sobell, H.M.: 1977, J. Mol. Biol. 114, pp. 317–331.

    Article  CAS  Google Scholar 

  17. Tsai, C.-C., Jain, S.C. and Sobell, H.M.: 1977, J. Mol. Biol. 114, pp. 333–365.

    Article  Google Scholar 

  18. Berman, H.M., Neidle, S. and Stodola, R.K.: 1978, Proc. Natl. Acad. Sci. USA 75, pp. 828–832.

    Article  CAS  Google Scholar 

  19. Tsai, C.-C., Jain, S.C. and Sobell, H.M.: 1975, Proc. Natl. Acad. Sci. USA 72, pp. 628–632.

    Article  CAS  Google Scholar 

  20. Sobell, H.M., Tsai, C.-C., Jain, S.-C. and Gilbert, S.G.: 1977, J. Mol. Biol. 114, pp. 333–365.

    Article  CAS  Google Scholar 

  21. Berman, H.M. and Neidle, S.: 1980, in: Nucleic Acid Geometry and Dynamics (Sarma, R.H. ed.) Pergamon Press, New York, pp. 367–382.

    Google Scholar 

  22. Gale, E.F., Cundcliffe, E., Reynolds, P.E., Richmond, M.H. and Waring, M.J.: 1982, The Molecular Basis of Antibiotic Action, 2nd ed., John Wiley, London.

    Google Scholar 

  23. Quigley, G.J., Wang, A.H.-J., Ughetto, G., van der Marel, G., Van Boom, J.H. and Rich, A.: 1980, Proc. Natl. Acad. Sci. USA 77, pp. 7204–7208.

    Article  CAS  Google Scholar 

  24. Fratini, A.V., Kopka, M.L., Drew, H.R. and Dickerson, R.E.: 1982, J. Biol. Chem. 257, pp. 14686–14707.

    CAS  Google Scholar 

  25. Shakked, Z., Rabinovich, D., Kennard, O., Cruse, W.B.T., Salisbury, S.A. and Viswamitra, M.A.: 1983, J. Mol. Biol. in press.

    Google Scholar 

  26. Dickerson, R.E. and Drew, H.R.: 1981, J. Mol. Biol. 149, pp. 761–786.

    Article  CAS  Google Scholar 

  27. Dearing, A., Weiner, P. and Kollman, P.A.: 1981, Nucleic Acids Res. 9, pp. 1483–1497.

    Article  CAS  Google Scholar 

  28. Neidle, S., Berman, H.M. and Shieh, H.S.: 1980, Nature 288, pp. 129–133.

    Article  CAS  Google Scholar 

  29. Neidle, S. and Berman, H.M.: 1982, in: Molecular Structure and Biological Activity (Griffin, J.F. and Duax, W.L. eds.) Elsevier, New York, pp. 287–301.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cancer Research Campaign Biomolecular Structure Research Group, Department of Biophysics, King’s College, London, WC2B 5RL, UK

    S. Neidle, R. Kuroda, A. Aggarwal & S. A. Islam

Authors
  1. S. Neidle
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Kuroda
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Aggarwal
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. A. Islam
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild), Universite Pierre et Marie Curie (Paris VI), Paris, France

    Bernard Pullman

  2. Department of Chemistry, Tel-Aviv University, Tel-Aviv, Israel

    Joshua Jortner

Rights and permissions

Reprints and permissions

Copyright information

© 1983 D. Reidel Publishing Company

About this paper

Cite this paper

Neidle, S., Kuroda, R., Aggarwal, A., Islam, S.A. (1983). Drug Nucleic Acid Interactions: Proflavine Intercalation into Double-Helical Fragments of RNA and DNA. In: Pullman, B., Jortner, J. (eds) Nucleic Acids: The Vectors of Life. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7225-4_38

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-7225-4_38

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-7227-8

  • Online ISBN: 978-94-009-7225-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation