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New Wrinkles on DNA

  • Conference paper
Nucleic Acids: The Vectors of Life

Part of the book series: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ((JSQC,volume 16))

Abstract

The B allomorph of poly d(GC):poly d(GC) at first sight appears to be quite similar to that of calf thymus DNA whose identical chains are described adequately as 101 helices of (average) mononucleotides. Nevertheless the chains of poly d(GC):poly d(GC) are significantly better described as 51 helices of dinucleotides in which GpC has more or less the same conformation as common B DNA but CpG has its C3’-03’ conformation gauche minus rather than trans. Consequently the phosphate orientations of alternate nucleotides differ dramatically justifying describing the conformation of this molecule as a wrinkled form of B DNA.

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Author information

Authors and Affiliations

  1. Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA

    Struther Arnott, R. Chandrasekaran, L. C. Puigjaner & J. K. Walker

Authors
  1. Struther Arnott
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  2. R. Chandrasekaran
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  3. L. C. Puigjaner
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  4. J. K. Walker
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Editor information

Editors and Affiliations

  1. Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild), Universite Pierre et Marie Curie (Paris VI), Paris, France

    Bernard Pullman

  2. Department of Chemistry, Tel-Aviv University, Tel-Aviv, Israel

    Joshua Jortner

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© 1983 D. Reidel Publishing Company

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Arnott, S., Chandrasekaran, R., Puigjaner, L.C., Walker, J.K. (1983). New Wrinkles on DNA. In: Pullman, B., Jortner, J. (eds) Nucleic Acids: The Vectors of Life. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7225-4_2

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  • DOI: https://doi.org/10.1007/978-94-009-7225-4_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-7227-8

  • Online ISBN: 978-94-009-7225-4

  • eBook Packages: Springer Book Archive

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