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DTIC: A Springboard to New Antitumour Agents

  • Chapter
Structure-Activity Relationships of Anti-Tumour Agents

Part of the book series: Developments in Pharmacology ((DIPH,volume 3))

Abstract

Although the history of the development of 5- (3, 3-dimethyl-triazen-l-yl) imidazole-4-carboxamide (DTIC; NSC 45388) has been fully documented (1–5) a definitive account of the mode of action of the drug has yet to appear. There are almost as many theories purporting to explain the mode of action of DTIC as there are chemists and biochemists who, ensnared by the apparent deceptive simplicity of the molecule, have responded to the challenge but abjectly failed in the task of unravelling its perverse secrets.

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Authors
  1. M. F. G. Stevens
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Editor information

Editors and Affiliations

  1. Department of Organic Chemistry, Technical University Twente, Enschede, The Netherlands

    D. N. Reinhoudt

  2. MRC Toxicology Unit, Medical Research Council Laboratories, Carshalton, Surrey, UK

    T. A. Connors

  3. Department of Biochemistry, Antonie van Leeuwenhoekziekenhuis, Amsterdam, The Netherlands

    H. M. Pinedo

  4. Koningin Wilhelmina Fonds, The Netherlands Cancer Foundation, Amsterdam, The Netherlands

    K. W. van de Poll

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© 1983 Martinus Nijhoff Publishers, The Hague, Boston, London

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Stevens, M.F.G. (1983). DTIC: A Springboard to New Antitumour Agents. In: Reinhoudt, D.N., Connors, T.A., Pinedo, H.M., van de Poll, K.W. (eds) Structure-Activity Relationships of Anti-Tumour Agents. Developments in Pharmacology, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6798-4_10

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  • DOI: https://doi.org/10.1007/978-94-009-6798-4_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6800-4

  • Online ISBN: 978-94-009-6798-4

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