Abstract
The unique bonding characteristics of UF45S5 Bioglass®1, 2, 3 (discussed in another chapter in this book, reference 4) prompted these investigators to pursue a series of experiments to evaluate Bioglass® in a middle ear setting. The incus replacement model was chosen and developed since it replicated many of the unique requirements of clinical ossicular reconstruction. Results in 60 mice of Bioglass® incus replacement for periods of 21 to 300 days indicated that Bioglass® rods remained in position on malleus or stapes or both in 85% and were stable to a blast of nitrogen gas and/or pick manipulation in 85%. Histologic study revealed rods entirely covered by a very thin capsule, in places only 1 or 2 collagen fibers thick, covered by normal appearing middle ear mucosa without any sign of inflammation5.
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© 1984 Martinus Nijhoff Publishers, Boston
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Merwin, G.E., Wilson, J., Hench, L.L. (1984). Current Status of the Development of BioglassR Ossicular Replacement Implants. In: Grote, J.J. (eds) Biomaterials in Otology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6756-4_26
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DOI: https://doi.org/10.1007/978-94-009-6756-4_26
Publisher Name: Springer, Dordrecht
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