Summary
In order to test the suitability of hydroxyapatite implants for use in tympanoplasty, a study was performed in which the behaviour of these biomaterials was observed in the infected middle ear of the rat. Infection was induced by means of intratympanical injection of a Staphylococcus aureus suspension. The reactions observed show great resemblance with the events witnessed in the middle ear infected without implant. Another similarity can be demonstrated between the implant inserted in the infected tympanon and the implant remaining in the non infected middle ear cavity. All implants are characterized by a mucosal and bony lining. Macropores, when present, become filled with fibrous tissue, gradually replaced by bone. The bonding between the tissue and the implant appears to be tight.
The results obtained from this study indicate the apparent suitability of sintered hydroxyapatite implants as means for substitution of bone in the middle ear.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Homsy, C. A., Kent, J., Hinds, E. 1973. Materials for oral implantation: biological and functional criteria. JADA, 86: 817.
Shea, J. J., Homsy, C. A. 1974. The use of Proplast in otologic surgery. Laryngoscope, 84: 1835.
Shea, J. J., Emmett, J. R., Smyth, G. D. L. 1977. Biocompatible implants in otology. ORL, 39: 9.
Jahnke, K., Plester, D., Heimke, G. 1979. Aluminium oxid keramik, ein bioinertes material fur die mittelohr chirurgie. Arch. Otorhinolaryngol., 223: 2.
Hench, L. L., Paschall, H. A. 1973. Direct bond of bioactive glassceramic materials to bone and muscle. J.Biomed. Mater. Res. Symp., 4: 25.
Kuypers, W., Grote, J. J. 1977. The use of Proplast in experimental middle ear surgery. Clin. Otolaryngol., 2: 15.
Grote, J. J., Kuypers, W. 1983. The use of biomaterials in reconstructive middle ear surgery. Biomaterials in reconstructive surgery. Ed. Rubin, R. J.: 987.
Teichgraeber, J. F., Spector, M., Per-Lee, J. H., Jackson, R. T. 1983. Tissue response to Plasti-pore and Proplast in the middle ear of cats. Am. J.Otology. (in press). 104
Johns, A. 1981. The use of Proplast in reconstruction of the posterior meatal wall. J.Laryngol. Otol., 95: 899.
Kerr, A. G. 1981. Proplast and Plastipore. Clin. Otolaryngol., 6:187.
Boedts, D., de Leeuw, I., Moenclaey, L. 1983. Mineral and collagen contents of human ossicles. Arch. Otorhinolaryngol., 237: 197.
Driessen, A. A., Klein, C. P. A. T., de Groot, K. 1982. Preparation and some properties of sintered B-whitlockite. Biomaterials, 3: 113.
Klein, C. P. A. T., Driessen, A. A., de Groot, K., van den Hooff, A. 1982. Biodegradation behaviour of various calciumphosphates in bone tissue. J.Biomed. Mater. Res.
Grote, J. J., Kuypers, W., de Groot K. 1981. Use of sintered hydroxyapatite in middle ear surgery. ORL, 43: 248.
Peelen, J. G. J., Rejda, B. V., de Groot, K. 1978. Preparation and properties of sintered hydroxyapatite. Ceramurgia Int., 5: 71.
Daems, W.Th., Brederoo, P. 1973. Electron microscopical studies on the structure, phagocytic properties and peroxidatic activity of resident and exudate peritoneal macrophages in the guinea pig. Z.Zellforsch, 144: 247.
Scherft, J. P. 1978. The lamina limitans of the organic bone matrix: formation in vitro. Journal of ultrastructure research, 64: 173.
v.d. Rhee, H. J. 1979. The differentiation of monocytes into macrophages epitheloid cells and multinucleated giant cells in subcutaneous granulomas. Cell tissue Res. Vol. 197, no. 3: 355–396.
Lucht, U. 1980. Osteoclasts: ultrastructure and functions. in: the reticuloendothelial system, Ed. Carr, J. Daems, W. Th. 1: 705.
Homsy, C. A. 1970. Biocompatibility in selection of materials for implantation. J.Biomed. Mater. Res. 4: 341.
Kuypers, W. 1983. Behaviour of bioimplants in the middle ear. Biomaterials. in otology.
Osborn, J. F., Newesly, H. 1982. Bonding osteogenesis induced by calciumphosphate ceramic implants. Biomaterials 1980, in: Advances in biomaterials, Ed. Winter, Gibbons, Plenck, 3: 51.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Martinus Nijhoff Publishers, Boston
About this chapter
Cite this chapter
Van Blitterswijk, C.A., Grote, J.J., Kuypers, W. (1984). Hydroxyapatite in the Infected Middle Ear. In: Grote, J.J. (eds) Biomaterials in Otology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6756-4_12
Download citation
DOI: https://doi.org/10.1007/978-94-009-6756-4_12
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-6758-8
Online ISBN: 978-94-009-6756-4
eBook Packages: Springer Book Archive