Skip to main content

Animal Models for Efficacy Studies — A Practical Approach

  • Chapter
Safety and efficacy of radiopharmaceuticals

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 4))

  • 97 Accesses

Abstract

Animal tests to determine the suitability of drugs for diagnostic or therapeutic use in humans can be broken down into toxicological and pharmacological studies.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Schwarz A, Kloss G. Beziehungen zwischen chemischer Struktur und Skelettfixierung verschiedener Tc-99m-Phosphonsäuren. In “Nuklearmedizin im interdisziplinären Bezug”. Proceed, of the 18th Internat. Annual Meeting of the Soc. of Nucl. Med.-Europe-, Nürnberg, Sept. 1980. Stuttgart, F.K. Schattauer-Verlag, 1981: 120–24.

    Google Scholar 

  2. Callery PS, et al. Tissue distribution of technetium-99m and carbon-14 labelled N-(2, 6-Dimethylphenylcarbamoylmethyl) iminodiacetic acid J Med Chem 1976; 19: 962–64.

    CAS  Google Scholar 

  3. Molter M, Kloss G. Neue TC-99m-IDA-Derivate für eine angepasste Leberfunktionsdiagnostik. In “Nuklearmedizin im interdisziplinären Bezug”. Proceed, of the 18th Internat. Annual Meeting of the Soc of Nucl. Med.-Europe-, Nürnberg, Sept. 1980. Stuttgart F.K. Schattauer-Verlag 1981: 116–19.

    Google Scholar 

  4. Wiebe LI. Small animal tumor models for screening diagnostic radiotracers. In Eckelmann WC, Lambrecht RM eds. (In press). Animal Models in Radiotracer Design. New York Springer Verlag 1983.

    Google Scholar 

  5. Rygaard J, Povlsecn CO. Heterotransplantation of a human malignant Tumour to “Nude” mice. Acta Pathol Microbiol Scand 1969;77: 758–60.

    Article  PubMed  CAS  Google Scholar 

  6. Pressman D. et al. The use of paired labelling in the determination of tumorlocalizing antibodies. Canc Res 1957; 17: 845–50.

    CAS  Google Scholar 

  7. Kloss G, Leven M. Accumulation of radioiodinated tyrosine derivatives in the adrenal medulla and in melanomas. Eur J Nucl Med 1979; 4: 179–86.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Martinus Nijhoff Publishers, Boston

About this chapter

Cite this chapter

Kloss, G. (1984). Animal Models for Efficacy Studies — A Practical Approach. In: Kristensen, K., Nørbygaard, E. (eds) Safety and efficacy of radiopharmaceuticals. Developments in Nuclear Medicine, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6753-3_9

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-6753-3_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6755-7

  • Online ISBN: 978-94-009-6753-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics