Abstract
Radiopharmaceuticals exert no pharmacological action on the tissues of the host organism not even in the case of therapeutic agents where the therapeutic effect is achieved as the result of radiation induced damage. Diagnostic reagents tend to follow well defined metabolic pathways in the body or they are passively transported unchanged as the result of physiological activity and the movement of body fluids. In either case the biodistribution reflects physiological activity and a divergence from normal distribution patterns will indicate the presence of pathophysiological processes. This assumption forms the whole basis of in vivo nuclear medical diagnosis.
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References
Subramanian G et al. The influence of structural changes on biodistribution of Tc-99m N-substituted Ida derivatives. In: Nuklearmedizin Proceedings 15th Congress Society of Nuclear Medicine (Europe). Ed: Schmidt HAE, and Woldring MG, Groningen.1977
Kung HF, Blau M. Synthesis of Se-75 labelled tertiary diamines — New Brain imaging agents. J Med Chem 1980; 23: 1127–1130.
Kung HF, Blau M. Regional intracellular pH shift. A proposed new mechanism for radiopharmaceutical uptake in brain and other tissues. J Nucl Med 1980; 21: 147–152.
Charkes ND, Philips CM. A new model of F-18 Fluoride Kinetics in Humans: Simulation by analoque computer. IN: Medical Radionuclide Imaging Vol II I.A.E.A. Vienna 1977: 137–144.
Larson SM et al., The transferrin Receptor Hypothesis: Mechanism of Tumor uptake of Carrier Free Gallium-67. In: Frontiers in Nuclear Medicine Ed: Horst W, Wagner HN and Buchanan JW, Springer Verlag, Berlin 1980: 134–153.
Fernandez - Pol J A. Molecular Basis of the Regulation of Iron-59 and Gallium-67 Transport in normal and Simian Virus 40 transformed cells In: Frontiers in Nuclear Medicine Ed: Horst W, Wagner HN and Buchanan JW, Springer Verlag, Berlin 1980: 162–182.
Muranaka A. Accumulation of Radioisotopes with tumour affinity. Acta Med Okayama 1978;32: 407–417.
Cox PH, Tc-99m complexes for skeletal scintigraphy Physicochemical Factors affecting bone and bone marrow uptake, Brit J Radiol 1974;47: 845–850.
Cox PH, Technetium Complexes for renal scintigraphy In: Progres in Radiopharmaco1ogy 3 Ed Cox PH, Martin Nijhoff The Hague 1982: 31–44.
Reinhold HS, Van de Berg, Blox A. Physiology of Tumours-Vascularity and Microcirculation In: Progres in Radiopharmacology I. Ed: Cox PH, Elsevier North Holland Amsterdam 1979: 13–22.
Van der Pompe WB, An ionic model to explain the distribution of metal chelates in normal and pathological tissues In: Progress in Radiopharmaco1ogy I. Ed:Cox PH, Elsevier North Holland. Amsterdam 1979: 31–44.
Hill JH, Wagner HN. Gallium uptake in regenerating rat liver J Nucl Med 1974;15: 818–820.
Hammersley PAG et al. Uptake of Ga in the regenerating rat liver and its relationship to lysosomal activity. Cancer Res 1975; 35: 5: 1154–1158.
Orü H. Tumor scanning with Gallium and its mechanism studied in rats. Strahlentherapie 1972;144:192–200.
Cox PH, Van der Pompe WB. An ionic model to explain the distribution patterns of tumour seeking radiopharmaceuticals in normal and pathological tissues Proceedings XIII Int Meeting Society of Nuclear Medicine-Copenhagen 1975: 1461–1467.
Subramanian G, McAffee TG. New Developments in Radiopharmaceuticals for Imaging. In Medical Radionuclide Imaging Vol I I.A.E.A. Vienna 1981: 429–452.
Cox PH, The Pharmacological Behavior of Technetium in Bone. In: Progress in Radiopharmaco1ogy I. Ed: Cox PH Elsevier North Holland Amsterdam 1979: 109–127.
Gumpel JM. The role of Radiocolloids in the treatment of Arthritis Rheumatology and Rehabilitation 1974; XIII:1–9.
LLoyd DC, Reeder ET. Chromosome aberrations and intraarticular Yttrium-90. Lancet 1978, I: 617.
Dandanundi VR et al. Radiotoxicity of Thallium-201 in Mouse Testis. J Nucl Med 1983; 24: 145–153.
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© 1984 Martinus Nijhoff Publishers, Boston
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Cox, P.H. (1984). Preclinical Studies — Radiopharmacology And Toxicology. In: Kristensen, K., Nørbygaard, E. (eds) Safety and efficacy of radiopharmaceuticals. Developments in Nuclear Medicine, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6753-3_8
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DOI: https://doi.org/10.1007/978-94-009-6753-3_8
Publisher Name: Springer, Dordrecht
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