Abstract
High frequency ventilation (HFV) is a new mode of mechanical ventilation in which the ventilatory rates are higher and the tidal volumes considerably smaller than those observed during spontaneous breathing. Using this technique, investigators from a number of centers have shown that it is possible to maintain eucapnia even when the tidal volumes (VD) are less than the anatomic dead space (VD). These results are clearly in conflict with traditional concepts of gas exchange which are based on the principle that adequate alveolar ventilation is possible only if VT is greater than VD. In an attempt to further our understanding of the mechanisms, by which HFV is effective, we have developed a theoretical model of gas mixing during HFV and we have performed experiments in hardware models, animals and humans to determine the effect of variables thought to be important during HFV. The purpose of this paper is to summarize some of our theoretical and experimental results relating to the mechanisms of gas exchange during HFV.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Slutsky AS. 1981. Gas mixing by cardiogenic oscillations: A quantitative, theoretical analysis. J. Appl. Physiol: Respiratory Environ. Exer. Physiol. 51(5): 1287–1293.
Fredberg JJ. 1980. Augmented diffusion in the airways can support pulmonary gas exchange. J. Appl. Physiol. Environ. Exercise Physiol. 49(2):232–283.
Slutsky AS, Drazen JM, Ingram RH Jr, Kamm RD, Shapiro AH, Fredberg JJ, Loring SH, Lehr J. 1980. Effective pulmonary ventilation with small volume oscillations at high frequency. Science 209: 609–611.
Slutsky AS, Brown R. 1982. Cardiogenic oscillations: a potential mechanism enhancing oxygenation during apneic respiration. Medical Hypotheses 8:393–400.
Taylor GI. 1953. Dispersion of soluble matter in solvent flowing slowly through a tube. Proc. Roy. Soc. A, 219: 186–203.
Aris R. 1956. On the dispersion of a solute in a fluid flowing through a tube. Proc. R. Soc. London Ser. A. 235: 67–77.
Watson EJ. Diffusion in oscillatory pipe flow. J. Fluid Mechanics (submitted).
Joshi CH, Kamm RD, Drazen JM, Slutsky AS. An experimental study of gas exchange in laminar oscillatory flow. J, Fluid Mech. (submitted).
Taylor GI. 1954. The dispersion of matter in turbulent flow through a pipe. Proc. Roy. Soc. A. 223: 446–468.
Scherer PW, Schendalman LH, Greene NM, Bouhuys A. 1975. Measurement of axial diffusivities in a model of the bronchial airways. J. Appl. Physiol. 38: 719–723.
Schroter RC, Sudlow MF. 1969. Flow patterns of the human bronchial airways. Respiration Physiology 7: 341–355.
Kamm RD, Drazen JM, Slutsky AS. 1983. Pulmonary gas transport in high frequency ventilation. Critical Reviews in Biomedical Engineering (In preparation).
Horsfield K, Cumming G. 1975. Morphology of the bronchial tree in the dog. Resp. Physiol. 26: 173–182.
Slutsky AS, Kamm RD, Rossing TH, Loring SH, Lehr J, Shapiro AH, Ingram RH Jr, Drazen JM. 1981. CO2 elimination in dogs by high frequency (3–30 Hz), low tidal volume ventilation: Effects of frequency, tidal volume and lung volume. J, Clin. Invest. 68: 1475–1484.
Khoo MCK, Slutsky AS, Drazen JM, Solway J, Gavriely N, Kamm RD. 1982. An improved model of gas transport during HFV (abstract). The Physiologist 25(4): 282.
Rossing TH, Slutsky AS, Lehr JL, Drinker RA, Kamm R, Drazen JM. 1981. Tidal volume and frequency dependence of carbon dioxide elimination by high-frequency ventilation. N. Engl. J. Med. 305: 1375–1379.
Mead J. 1969. Contribution of compliance of airways to frequency dependent behavior of the lungs. J. Appl. Physiol. 26:670–673.
Rossing TH, Slutsky AS, Ingram RH Jr, Kamm RD, Shapiro AH, Drazen JM. CO2 elimination by high frequency oscillation in dogs - effects of histamine infusion. J. Appl. Physiol. Respir. Environ. Exercise Physiol. (in press).
Slutsky AS, Kamm RD, Drazen JM. High frequency oscillatory ventilation using tidal volumes smaller than the anatomic dead space. In, International Anesthesiology Clinics. Little, Brown and Co., Boston, MA., Eds., R.B. Smith and U. Sjöstrand, in press.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Martinus Nijhoff Publishers, Boston
About this chapter
Cite this chapter
Slutsky, A.S., Kamm, R.D., Drazen, J.M. (1983). A Review of Experimental and Theoretical Studies of High Frequency Ventilation. In: Scheck, P.A., Sjöstrand, U.H., Smith, R.B. (eds) Perspectives in High Frequency Ventilation. Developments in Critical Care Medicine and Anesthesiology, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6711-3_5
Download citation
DOI: https://doi.org/10.1007/978-94-009-6711-3_5
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-6713-7
Online ISBN: 978-94-009-6711-3
eBook Packages: Springer Book Archive