Abstract
The old adage reminding us that ‘the newborn infant is more than a miniature version of the adult’ is never more important than when considering drug therapy. Indeed, during the immediate postnatal period, the infant is biochemically, physiologically and microbiologically distinct from the adult of its species. Since drug therapy is designed to manipulate biochemistry, physiology, or flora, it is not unexpected that the approach to treatment of disease in the newborn has unique features.
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References
Alexander, D. P. and Nixon, D. A. (1962). Plasma clearance of p-aminohippuric acid and inulin by the kidneys of foetal, neonatal and adult sheep. Nature (London), 194, 483 – 4
Barnett, H. L., McNamara, H., Shultz, S. et al (1949). Renal clearances of sodium penicillin G, procaine penicillin G, and inulin in infants and children. Pediatrics, 3, 418 – 22
Baxter, J. S. and Yoffey, J. M. (1947). The post–natal development of renal tubules in the rat. Anatomy, 82, 189 – 97
Bogomolova, N. A. (1965). Age changes in kidney of White rat. Arkh. Anat. Gistol. Embriol, 48, T295 – 9
Calcagno, P. L. and Rubin, M. I. (1963). Renal extraction of para–aminohippurate in infants and children. J. Clin. Invest., 42 1632–9
Dalton, R. G. (1968). Renal function in neonatal calves: inulin, thiosulfate and PAH clearance. Br. Vet. J, 124, 489 – 98
Edelmann, C. M. (1966). Maturation of the neonatal kidney. Proc. Int. Congr. Nephrol, Washington, 3, 1 – 12
Fetterman, G. H., Shuplock, N. A., Philipp, F. J. etal. (1965). The growth and maturation of human glomeruli and proximal convolutions from term to adulthood. Pediatrics, 35, 601–19
Gruskin, A. G., Edelmann, C. M. and Yaun, S. (1970). Maturational changes in renal blood flow in piglets. Pediatr. Res, 4, 7 – 13
Hirsch, G. H., Cowan, D. F. and Hook, J. B. (1971). Histological changes in normal and drug–induced development of renal PAH transport. Proc. Soc. Exp. Biol. Med, 137, 116 – 21
Horster, M. and Valtin, H. (1971). Postnatal development of renal function: micropuncture and clearance studies in the dog. J. Clin. Invest, 50, 779 – 95
McCraken, G. H., Ginsburg, C. and Chrane, D. F. (1973). Clinical pharmacology of penicillin in newborn infants. J. Pediatr, 82, 692 – 8
McCraken, G. H. and Nelson, J. D. (1977). Antimicrobial therapy for newborns. In Monographs in Neonatology (New York: Grune and Stratton)
New, N., McNamara, H. and Kretchmer, N. (1959). Accumulation of para–aminohippurate by slices of kidney from rabbits of various ages. Proc. Soc. Exp. Biol. Med, 102, 558 – 60
Potter, E. L. and Thierstein, S. T. (1943). Glomerular development in the kidney as an index of fetal maturity. J. Pediatr, 22, 695 – 706
Reiche, R., Mulling, M. and Frey, H. H. (1980). Pharmacokinetics of chloramphenicol in calves during the first weeks of life. J. Vet. Pharmacol. Ther, 3, 95 – 106
Rennick, B., Hamilton, B. and Evans,. R. (1961). Development of renal tubular transports of TEA and PAH in the puppy and piglet. Am. J. Physiol, 201, 743 – 6
Schreiter, G. (1966). Neue physiologische und klinische Aspekt der Nieren–Funktion bei Frudgeborenen. Dtsch. Gesundh. Wesen, 21, 433 – 41
Short, C. R. and Davis, L. E. (1970). Postnatal development of drug metabolizing enzyme activity in swine. J. Pharmacol. Exp. Ther, 174, 185 – 96
Short, C. R., Kinden, D. A. and Stith, R. (1976). Fetal and neonatal development of the microsomal monooxygenase system. Drug Metab. Rev, 5, 1 – 42
Short, C. R. and Stith, R. (1973). Perinatal development of hepatic mixed function oxidase activity in swine. Biochem. Pharmacol, 22, 1309 – 19
Short, C. R. (1980). Drug elimination in the newborn animal. Proc. Symp. Vet. Pharmacol. Ther, Philadelphia, 2, 81 – 99
Short, C. R. and Tumbleson, M. E. (1973). Binding of drugs to plasma proteins of swine during the perinatal period. Toxicol. Appl. Pharmacol, 24, 612 – 24
Svendsen, O. (1976). Pharmacokinetics of hexobarbital, sulfadimidine and chloramphenicol in neonatal and young pigs. Acta Vet. Scand, 17, 1 – 14
Vogh, B. and Cassin, S. (1966). Stop flow analysis of renal function in newborn and maturing swine. Biol. Neonate, 10, 153–65 16. West, J. R., Smith, H. W. and Chasis, H. (1948). Glomerular filtration rate, effective renal blood flow, and maximal tubular excretory capacity in infancy. J. Pediatr, 32, 10 – 18
West, J.R., Smith, H.W. and Chasis H. (1948). Glomerular filtration rate, effevtive renal blood flow, and maximal tubular excretory capacity in infancy. J. Pediatr., 32, 10–18
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© 1983 MTP Press Limited
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Short, C.R. (1983). Developmental patterns of penicillin G excretion. In: Ruckebusch, Y., Toutain, PL., Koritz, G.D. (eds) Veterinary Pharmacology and Toxicology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6604-8_6
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DOI: https://doi.org/10.1007/978-94-009-6604-8_6
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-6606-2
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