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Multiplicity of kappa opiate sites in the central nervous system

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Veterinary Pharmacology and Toxicology

Abstract

The pharmacochemical requirements for morphinomimetic action21, 39 have led to the search for and characterization of an opiate receptor in the central nervous system of mammals43, 46, 48. The existence of this receptor suggested the presence of an endogenous substance for which this binding site would be the physiological target and for which the exogenous opiates would substitute to induce their pharmacological effects. Such a hypothesis was corroborated by the isolation of the enkephalins26, two related pentapeptides, whose biological actions7, 23, 26 and regional distribution14, 27 corresponded to the pharmacological effects of opiates and the localization of the opiate binding sites32.

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Authors
  1. Y. Audigier
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  2. B. Attali
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  3. C. Gouardères
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  4. H. Mazarguil
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  5. J. Cros
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Editor information

Editors and Affiliations

  1. Ecole Nationale Vétérinaire, 23, chemin des Capelles, 31076, Toulouse Cédex, France

    Yves Ruckebusch

  2. Pharmacologie-Toxicologie, INRA, 180, chemin de Tournefeuille, 31300, Toulouse, France

    Pierre-Louis Toutain

  3. College of Veterinary Medicine, University of Illinois, 61801, Urbana, Illinois, USA

    Gary D. Koritz

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© 1983 MTP Press Limited

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Audigier, Y., Attali, B., Gouardères, C., Mazarguil, H., Cros, J. (1983). Multiplicity of kappa opiate sites in the central nervous system. In: Ruckebusch, Y., Toutain, PL., Koritz, G.D. (eds) Veterinary Pharmacology and Toxicology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6604-8_45

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  • DOI: https://doi.org/10.1007/978-94-009-6604-8_45

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6606-2

  • Online ISBN: 978-94-009-6604-8

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