Abstract
The receptor theory is not a new one. It was first introduced at the beginning of this century between 1905 and 1910 by Ehrlich working on tetanus toxin and trypanocidal dyes and Langley working on the action of nicotine and curare on muscle16. At that time, of course, very limited proof supported this notion which was almost purely conceptuall. However, many pharmacological studies thereafter, especially those of Clark around 1926, reinforced the interest in this concept which became very fruitful and was finally validated during the 1960s when the existence of receptors was directly established, thanks to the development of binding techniques with radio-labelled ligands1. A new and decisive stage was reached with the isolation around 1977 of the nicotinic receptor from the electric organ of electric fishes11.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ariens, E. J. (1979). Receptors: from fiction to fact. T.I.P.S.,1, 11–15
Bardone, M. C., Ducrot, R., Garret, C. et al. (1978). Benzodiazepine-like central effects of RP 27 267, a dihydro-7-oxo-5 H-pyrrolo [3, 4-b] pyrazine derivative. Presented at7th International Congress of Pharmacology, Paris. Abstract 2319
Blanchard, J. C., Boireau, A., Garret, C. et al. (1979). In vitro and in vivo inhibition by zopiclone of benzodiazepine binding to rodent brain receptors.Life Sci,24, 2417–20
Blanchard, J. C. and Julou, L. (1983). Suriclone: a new cyclopyrrolone derivative recognizing receptors labelled by benzodiazepines in rat hippocampus and cerebellum.J. Neurochem,50, 601–7
Blanchard, J. C., Boireau, A. and Julou, L. (1982). Brain receptors and zopiclone. Presented at13th C.I.N.P. Congress, Jerusalem. Abst. p. 799
Braestrup, C., Albrechtsen, R. and Squires, R. F. (1977). High densities of benzodiazepine receptors in human cortical areas.Nature (London),263, 702–4
Burch, T. P. and Ticku, M. K. (1981). Histidine modification with diethylpyrocarbonate shows heterogeneity of benzodiazepine receptors.Proc. Natl. Acad. Sci,78, 3945–9
Cuatrecasas, P., Hollenberg, M. D., Chang, K.-J. et al. (1975). Hormone receptor complexes and their modulation of membrane function.Rec. Prog. Horm. Res,31, 37–84
Gallager, D. W., Mallorga, P., Thomas, J. W. et al. (1980). GABA-benzodiazepine interactions: physiological, pharmacological and developmental aspects.Fed. Proc,39, 3043–9
Garret, C., Bardone, M. C., Blanchard, J. C. et al. (1982). Pharmacological studies of suriclone (RP 31 264) a cyclopyrrolone derivative with anxiolytic properties. Presented at13th C.I.N.P. Congress, Jerusalem. Abst. p. 244
Heidmann, T. and Changeux, J. P. (1978). Structural and functional properties of the acetylcholine receptor protein in its purified and membrane bound states.Ann. Rev. Biochem,47, 317–57
Marangos, P. J., Paul, S. M. and Goodwin, F. K. (1979). Putative endogenous ligands for the benzodiazepine receptor.Life Sci,25, 1093–102
Möhler, H. and Okada, T. (1977). Benzodiazepine receptor: demonstration in the central nervous system.Science,198, 849–51
Möhler, H. and Okada, T. (1978). Biochemical identification site of action of benzodiazepines in human brain by 3H diazepam binding.Life Sci, 22, 985–96
Olsen, R. W. (1981). GABA-benzodiazepine-barbiturate receptor interactions.Neurochem,37, 1–13
Parascandola, J. (1980). Origins of the receptor theory.T.I.P.S,1, 189–92
Sherman-Gold, R. and Dudai, Y. (1981). Involvement of tyrosyl residues in the binding of benzodiazepines to their brain receptor.FEBS Letters,131, 313–6
Snyder, S. H. (1978). Overview of neurotransmitter receptor binding. In Neurotransmitter Receptor Binding, pp. 1 - 11. ( New York: Raven Press )
Squires, R. F. and Braestrup, C. (1977). Benzodiazepine receptors in rat brain.Nature (London),266, 732 - 4
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 MTP Press Limited
About this chapter
Cite this chapter
Blanchard, J.C., Julou, L. (1983). Receptor binding methods: application to the study of cyclopyrrolones, a new family of minor tranquillizers. In: Ruckebusch, Y., Toutain, PL., Koritz, G.D. (eds) Veterinary Pharmacology and Toxicology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6604-8_44
Download citation
DOI: https://doi.org/10.1007/978-94-009-6604-8_44
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-6606-2
Online ISBN: 978-94-009-6604-8
eBook Packages: Springer Book Archive