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Efficacy of penicillin against Streptococcus zooepidemicus. Infection model in the horse

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Book cover Veterinary Pharmacology and Toxicology

Abstract

Experimental infectious models of target animal species are useful for determining in vivo pharmacological efficacy and dosage regimens of antimicrobial agents4. In antimicrobial therapy, the ultimate aim is to maintain the drug in the biophase surrounding the pathogen at a concen­tration and for the duration that is optimum for eliminating the pathogen from the body. In clinical practice, the minimum inhibitory concentration (MIC) of the antibiotic for the pathogen may be determined and efforts are made to maintain the drug concentration in blood equal to or higher than the MIC.

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References

  1. Cartwright, G. E., Gubler, C. J. and Wintrobe, M. M. (1950). The anemia of infection. XII. The effect of temperature and coloidal thorium dioxide on the plasma iron and plasma copper in dogs.J. Biol. Chem,184, 579–87

    PubMed  CAS  Google Scholar 

  2. Cartwright, G. E., Lauritsen, A., Humphries, S. et al. (1946). The anemia of infection. II. The experimental production of hypoferremia and anemia in dogs.J. Clin. Invest,25, 81–8

    Article  CAS  Google Scholar 

  3. Kluger, M. J. and Rothenburg, B. A. (1979). Fever and reduced iron: their interaction as a host defense response to bacterial infection.Science,203, 374–6

    Article  PubMed  CAS  Google Scholar 

  4. Powers, T. E., Powers, J. D., Garg, R. C. et al. (1980). Trimethoprim and sulfadiazine: experimental infection of Beagles.Am. J. Vet. Res,41, 1117–22

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Authors
  1. K. J. Varma
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  2. T. E. Powers
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  3. R. C. Garg
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  4. S. L. Spurlock
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  5. J. D. Powers
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Editor information

Editors and Affiliations

  1. Ecole Nationale Vétérinaire, 23, chemin des Capelles, 31076, Toulouse Cédex, France

    Yves Ruckebusch

  2. Pharmacologie-Toxicologie, INRA, 180, chemin de Tournefeuille, 31300, Toulouse, France

    Pierre-Louis Toutain

  3. College of Veterinary Medicine, University of Illinois, 61801, Urbana, Illinois, USA

    Gary D. Koritz

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© 1983 MTP Press Limited

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Varma, K.J., Powers, T.E., Garg, R.C., Spurlock, S.L., Powers, J.D. (1983). Efficacy of penicillin against Streptococcus zooepidemicus. Infection model in the horse. In: Ruckebusch, Y., Toutain, PL., Koritz, G.D. (eds) Veterinary Pharmacology and Toxicology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6604-8_43

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  • DOI: https://doi.org/10.1007/978-94-009-6604-8_43

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6606-2

  • Online ISBN: 978-94-009-6604-8

  • eBook Packages: Springer Book Archive

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