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Fever, trace metals and disease. The effect of antipyretic agents

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Veterinary Pharmacology and Toxicology

Abstract

Many infectious diseases are accompanied by fever associated with a rapid decline in plasma iron concentration and plasma zinc concentration3, 10, 14, 26. Similar responses occur in experimental animals when sterile inflammation is produced, such as E. coli endotoxin-induced mastitis22, 27 or following intravenous injection of pyrogens3,4 10, 22–24,27. it is generally believed that fever is mediated by an endogenous pyrogen (EP), a protein which is released from cells of the reticuloendothelial system and which acts on central nervous system temperature regulating centres1. An analogous endogenous substance produced by phagocytic cells has subsequently been found to mediate the changes in plasma trace metals, which occur in conjunction with fever3, 11. This substance has been termed leukocytic endogenous mediator (LEM). The relationship between EP and LEM has not been determined with certainty12, 17.

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Authors
  1. A. S. J. P. A. M. Van Miert
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  2. D. Zwart
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  3. J. H. M. Verheijden
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  4. A. J. H. Schotman
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Editor information

Editors and Affiliations

  1. Ecole Nationale Vétérinaire, 23, chemin des Capelles, 31076, Toulouse Cédex, France

    Yves Ruckebusch

  2. Pharmacologie-Toxicologie, INRA, 180, chemin de Tournefeuille, 31300, Toulouse, France

    Pierre-Louis Toutain

  3. College of Veterinary Medicine, University of Illinois, 61801, Urbana, Illinois, USA

    Gary D. Koritz

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© 1983 MTP Press Limited

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Van Miert, A.S.J.P.A.M., Zwart, D., Verheijden, J.H.M., Schotman, A.J.H. (1983). Fever, trace metals and disease. The effect of antipyretic agents. In: Ruckebusch, Y., Toutain, PL., Koritz, G.D. (eds) Veterinary Pharmacology and Toxicology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6604-8_42

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  • DOI: https://doi.org/10.1007/978-94-009-6604-8_42

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6606-2

  • Online ISBN: 978-94-009-6604-8

  • eBook Packages: Springer Book Archive

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