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Steroidal anti-inflammatory agents in the horse: pharmacokinetics and action on the adrenal gland

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Veterinary Pharmacology and Toxicology

Abstract

Although the non-steroidal anti-inflammatory agents are the most useful anti-inflammatory drugs in equine practice, corticosteroids are also used for a variety of conditions such as endotoxic shock, arthritis, pulmonary diseases, etc. In addition, the psychostimulant effect of corticosteroids has led to their large and uncontrolled misuse in racing horses in order to improve performance. The pharmacological properties and therapeutic indications of synthetic cortiscosteroids are documented for the horse. In contrast, information on the pharmacokinetics and the effects of these agents on the adrenal gland are scant or absent. The objectives of the present report are to review the information available in these two fields and to present unpublished data obtained on dexamethasone and prednisolone in the horse.

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Authors
  1. P. L. Toutain
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  2. R. A. Brandon
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Editor information

Editors and Affiliations

  1. Ecole Nationale Vétérinaire, 23, chemin des Capelles, 31076, Toulouse Cédex, France

    Yves Ruckebusch

  2. Pharmacologie-Toxicologie, INRA, 180, chemin de Tournefeuille, 31300, Toulouse, France

    Pierre-Louis Toutain

  3. College of Veterinary Medicine, University of Illinois, 61801, Urbana, Illinois, USA

    Gary D. Koritz

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© 1983 MTP Press Limited

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Toutain, P.L., Brandon, R.A. (1983). Steroidal anti-inflammatory agents in the horse: pharmacokinetics and action on the adrenal gland. In: Ruckebusch, Y., Toutain, PL., Koritz, G.D. (eds) Veterinary Pharmacology and Toxicology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6604-8_35

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  • DOI: https://doi.org/10.1007/978-94-009-6604-8_35

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6606-2

  • Online ISBN: 978-94-009-6604-8

  • eBook Packages: Springer Book Archive

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