Abstract
In man, diarrhoea mainly affects children (500 million annually world–wide) and is the leading cause of death in children under 4 years26. In animals, diarrhoea also mainly occurs in the neonatal period. One of the main charac–teristics of diarrhoea in animals as well as in humans is the diversity of aetiologies within the same species.
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Adler, H. F. and Ivy, A. C. (1940). Morphine atropine antagonism on colon motility in dog. J. Pharmacol. Exp. Ther., 70, 454
Argenzio, R. A. (1980). Glucose-stimulated fluid absorption in the pig small intestine during the early stage of swine dysentery. Am. J. Vet. Res., 41, 2000–6
Awouters, F., Niemegeers, C. J. E. and Janssen, P. A. J. (1983). Pharmacology of anti-diarrhoeal drugs. Am. Rev. Pharmacol. Toxicol. (In press)
Awouters, F., Niemegeers, C. J. E., Lenaerts, F. M. et al. (1978). Delay of castor-oil diarrhoea: a new way to evaluate inhibitors of prostaglandin biosynthesis. J. Pharm. Pharmacol., 30, 41–5
Awouters, F., Niemegeers, C. J. E., Kuyps, J. et al. (1975). Loperamide antagonism of castor-oil-induced diarrhoea in rats: a quantitative study. Arch. Int. Pharmacodyn. Ther., 217, 29–37
Bachrach, W. H. (1958). Anticholinergic drugs. Survey of literature and some experimental observations. Am. J. Dig. Dis., 3, 743–99
Beubler, E. and Lembeck, F. (1979). Inhibition of stimulated fluid secretion in the rat small and large intestine by opiate agonist. Arch. Pharmacol., 306, 113
Bueno, L. and Ruckebusch, Y. (1978). Effect of anticholinergic drugs on the electrical activity of antrum and duodeno-jejunum in sheep. J. Vet. Pharmacol. Ther., 1, 225–32
Bueno, L. and Ruckebusch, Y. (1978). Origine centrale de Taction excito–motrice de l’intestin de la morphine. C.R. Soc. Biol., 172, 972–7
Bueno, L., Fioramonti, J., Ruckebusch, M. et al. (1980). Evaluation of colonic myo– electrical activity and functional disorders. Gut, 21, 480–5
Bueno, L., Fioramonti, J. and Ruckebusch, Y. (1980). Digestive disturbances in ruminants: an electromyographic study. Vet. Sci. Comm., 4, 29–38
Bueno, L., Fioramonti, J. and Ruckebusch, Y. (1981). Comparative effects of morphine and nalorphine on colonic motility in the conscious dog. Eur. J. Pharmacol., 75, 239–45
Bueno, L. and Fioramonti, J. (1982). A possible central serotonergic mechanism involved in the effects of morphine on colonic motility in dog. Eur. J. Pharmacol., 82, 147–53
Burks, T. F. (1973). Mediation by 5-hydroxytryptamine of morphine stimulant actions in dog intestine. J. Pharmacol. Exp. Ther., 185, 530
Butterworth, B. S. (1982). The pharmacokinetics of loperamide in animals. (Unpublished review)
Bywater, R. J. (1980). Comparison between milk deprivation and oral rehydration with a glucose-glycine-electrolyte formulation in diarrhoeic and transported calves. Vet. Rec., 107, 549–51
Campbell, G. (1966). Nerve mediated excitation of the taenia of the guinea-pig caecum. J. Physiol., 185, 148–59
Christensen, J., Weisbrodt, N. W. and Hauser, R. L. (1972). Electrical slow wave of the proximal colon of the cat in diarrhoea. Gastroenterology, 62, 1167–73
Connel, A. M. (1962). The motility of the pelvic colon. II. Paradoxical motility in diarrhoea and constipation. Gut, 3, 342–8
Coudert, P., Licois, D. and Provot, F. (1976). Etude comparee de quatre coccidioses intestinales du lapin: pathogenicity, bilan economique, chimioprevention et chimiotherapie. Paper presented at ler Cong. Int. Cunicole, Dijon, France
Coussement, W., Ducatelle, R., Charlier, G. et al. (1981). Adenovirus enteritis in pigs. Am. J. Vet. Res., 42, 1905–10
Fioramonti, J., Garcia-Villar, R., Bueno, L. et al. (1980). Colonic myoelectrical activity and propulsion in dog. Dig. Dis. Sci., 25, 641–6
Fioramonti, J. (1981). Etude comparee des fonctions motrices du gros intestin. These Doct. Sci. Nat., Toulouse
Fioramonti, J., Sorraing, J. M., Licois, D. et al. (1981). Intestinal motor and transit disturb–ances associated with experimental coccidiosis (Eimeria magna) in the rabbit. Ann. Rech. Vet., 12, 413–20
Garcia-Villar, R., Leng–Peschlow, E. and Ruckebusch, Y. (1980). Effect of anthraquinone derivatives on canine and rat intestinal motility. J. Pharm. Pharmacol., 32, 323–9
Hirschhorn, N. (1980). The treatment of actute diarrhoea in children. An historical and physiological perspective. Am. J. Clin. Nutr., 33, 637–63
Holmgren, J. and Greenough, W. B. (1980). Reversal of enterotoxic diarrhoea by chlor- promazine and related drugs. In Field, M., Fordhan, J. S. and Schultz, D. G. (eds.) Secretory Diarrhoea, pp. 211–18. (Baltimore: Am. Physiol. Soc.)
Hood, D. M., Stephens, K. A. and Bowen, M. J. (1982). Phenoxybenzamine for the treat-ment of severe nonresponsive diarrhoea in the horse. J. Am. Vet. Assoc., 180, 758–62
Ilundain, A. and Naftalin, R. J. (1979). Role of Ca2+–dependent regulator proteins in intestinal secretion. Nature (London), 279, 446–8
Ilundain, A. and Naftalin, R. J. (1981). Opiates increase chloride permeability of the serosal border of rabbit ileum. J. Physiol., 316, 56–7
Ingram, D. M. and Catchpole, B. N. (1981). Effects of opiates on gastroduodenal motility following surgical operation. Dig. Dis. Sci., 26, 989–92
Latour, A. and Bueno, L. (1980). A micro-computerized system to measure the colonic contractile activity. Int. J. Bio-Med. Compt., 11, 389–96
Licois, D., Coudert, P. and Mongin, P. (1978). Changes in hydromineral metabolism in diarrhoeic rabbits. I. A study of the changes in water metabolism. Ann. Rech. Vet., 9, 1–10
Martin, S. W. and Wiggins, A. D. (1973). A model of the economic costs of dairy calf mortality. Am. J. Vet. Res., 34, 1027–31
Mebus, C. A., Stair, E. L., Inderdahl, N. R. et al. (1973). Calf diarrhoea of viral etiology. Ann. Rech. Vet., 4, 71–6
Niemegeers, C. J. E., Colpaerts, F. C. and Awouters, F. H. L. (1981). Pharmacology and antidiarrhoeal effect of loperamide. Drug Dev. Res., 1, 1–20
Niemegeers, C. J. E., Lenaerts, F. and Awouters, F. (1976). Preclinical animal studies of modern antidiarrhoeals. In vivo pharmacology. In van Bever, W. and Lai, H. (eds.) Synthetic Antidiarrhoeal Drugs, pp. 65–114. ( New York: Marcel Dekker )
Niemegeers, C. J. E., McGuire, J. C., Heykants, J. J. P. et al. (1979). Experimental dissociation between opiate-like and antidiarrhoeal drugs. J. Pharmacol. Exp. Ther., 210, 327–33
Pearson, G. R. and Logan, E. F. (1982). Ultrastructural changes in the small intestine on neonatal calves with enteric colibacillosis. Vet. Pathol., 19, 190–201
Peeters, J. E., Geeroms, R., Froyman, R. et al. (1981). Coccidiosis in rabbits: a field study. Res. Vet. Sci., 30, 328–34
Raynaud, J. P., Brunault, G. and Patterson, E. B. (1981). A swine dysentery model for evaluation of drug prophylaxis: development of a model involving oral infection plus pen contamination. Am. J. Vet. Res., 42, 49–50
Raynaud, J. P., Brunault, G. and Patterson, E. B. (1981). A swine dysentery model for evaluation of drug prophylaxis: efficacy of various drugs in the control of swine dysentery. Am. J. Vet. Res., 42, 51–3
Read, M. and Read, N. W. (1981). Anal sphincter function in diarrhoea: influence of loperamide. Clin. Res. Rev., 1 ( Suppl. I), 73–81
Rozental, G., Frexinos, J., Gerardin, A. et al. (1982). Modifications de l’activite myoelectrique du colon humain induites par le sulfate d’atropine. Paper presented at VIe Journees Francophones d’Hepatologie et de Gastroenterologie, Paris
Ruckebusch, Y. and Bueno, L. (1975). Electrical activity of the ovine jejunum and changes due to disturbances. Am. J. Dig. Dis., 20, 1027–1934
Ruckebusch, Y. and Fioramonti, J. (1980). Motor profile of the ruminant colon: hard vs soft faeces production. Experientia, 36, 1184–5
Sandhu, B. K., Tripp, J. H., Candy, D. C. A. et al. (1981). Loperamide: studies on its mechanism of action. Gut, 22, 658–62
Sitarska, E. and Pytkowski, S. T. (1968). Effects of prophylactical and therapeutical application of gamma-globulin in foal’s diarrhoea. Medycyna Weterynaryjna (Lublin, Poland), 24, 34–6
Targowski, S. P. (1976). Treatment of horses with chronic diarrhoea: immunologic status. Am. J. Vet. Res., 37, 29–33
Teige, J., Tollersrud, S., Lund, A. et al. (1982). Swine dysentery: the influence of dietary vitamin E and selenium on the clinical and pathological effects of Treponema hyo-dysenteriae infection in pigs. Res. Vet. Sci., 32, 95–100.
Thompson, D. G., Laidlow, J. M. and Wingate, D. L. (1979). Abnormal small-bowel motility demonstrated by radiotelemetry in a patient with irritable colon. Lancet, 1, 1321–4
van Nueten, J. M., Janssen, P. A. J. and Fontaine, J. (1974). Loperamide (R 18 553) a novel type of antidiarrhoeal agent. 3. In vitro studies on the peristaltic reflex and other experiments on isolated tissues. Arzneim. Forsch., 24, 1641–5
Verhaeren, E. H. C., Dreessen, M. J. and Lemli, V. A. (1981). Influence of 1.8-dihydroxy- anthraquenone and loperamide on the paracellular permeability across colonic mucosa. J. Pharm. Pharmacol., 33, 526–8
Wangel, A. G. and Deller, D. J. (1965). Intestinal motility in man. II. Mechanisms of constipation and diarrhoea with particular reference to the irritable bowel syndrome. Gastroenterology, 48, 69–83
Weisbrodt, N. W., Sussman, S. E., Stewart, J. J. et al. (1980). Effect of morphine sulfate on intestinal transit and myoelectrical activity of small intestine of the rat. J. Pharmacol. Exp. Ther., 214, 333–8
Whipp, S. C., Robinson, I. M., Harris, D. L. et al. (1979). Pathogenic synergism between Treponema hyodysenteriae and other selected anaerobes in gnotobiotic pigs. Infect. Immun., 26, 1042–7
Windsor, R. S. (1979). Swine dysentery. In Grunsell, C. G. S. and Hill, F. W. G. (eds.) The Veterinary Annual, pp. 88–96. ( Bristol: John Wright & Sons )
Wuester, M. and Herz, A. (1978). Opiate agonist action of antidiarrhoeal agents in vitro and In vivo findings in support of selective action. Naunyn-Schmiedeberg’s Arch. Pharmacol., 301, 187–94
Zavecz, J. H., Jacxson, T. E., Limp, G. L. et al. (1982). Relationship between anti-diarrhoeal activity and binding to calmodulin. Eur. J. Pharmacol., 78, 375–7
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Fioramonti, J., Niemegeers, C.J.E., Awouters, F. (1983). Diarrhoea and antidiarrhoeal drugs. In: Ruckebusch, Y., Toutain, PL., Koritz, G.D. (eds) Veterinary Pharmacology and Toxicology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6604-8_31
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DOI: https://doi.org/10.1007/978-94-009-6604-8_31
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