Skip to main content

Drug disposition in the fetus

  • Chapter

Abstract

The fetotoxic and teratogenic properties of several drugs and other substances have been extensively studied in small experimental animals. The mechanisms behind the effects caused by these agents are not always known. Distribution studies, e.g. using whole body autoradiography, is one route which together with many others may finally lead to a better understanding of the influence of chemicals on fetal development.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   139.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anderson, D. F., Stock, M. K. and Rankin, J. H. G. (1979). Placental transfer of dexamethasone in near-term sheep. J. Dev. Physiol., 1, 431–6

    CAS  PubMed  Google Scholar 

  2. André, T. (1956). Studies on the distribution of tritium-labelled dihydrostreptomycin and tetracycline in the body. Acta Radiol. Suppl., 142, 1–89

    PubMed  Google Scholar 

  3. Appelgren, L.-E. (1967). Sites of steroid hormone formation. Autoradiographic studies using labelled precursors. Acta Physiol. Scand. Suppl., 301, 1–108

    CAS  PubMed  Google Scholar 

  4. Appelgren, L.-E. (1969). Histochemical demonstration of drug interference with progesterone synthesis. J. Reprod. Fert, 19, 185–6

    Article  CAS  Google Scholar 

  5. Appelgren, L.-E. (1969). Interference with progesterone synthesis of some antifertility compounds as shown by histochemistry. Presented at the 2nd European Congress on Sterility, October 8 – 11, Dubrovnik, Yugoslavia

    Google Scholar 

  6. Appelgren, L.-E. (1972). Distribution of labelled chlormadinone acetate in mice. Abstract No. 47 of volunteer papers. Presented at the Fifth International Congress on Pharmacology, July 23–28, San Francisco, California

    Google Scholar 

  7. Appelgren, L.-E., Ericsson, Y. and Ullberg, S. (1961). A comparison of the distribution of radioactive fluorine and calcium by use of double-isotope autoradiography. Acta Physiol. Scand, 53, 339–47

    Article  CAS  PubMed  Google Scholar 

  8. Appelgren, L.-E. and Arora, R. G. (1982). Distribution studies of 14C-labelled aflatoxin Bi and ochratoxin A in pregnant mice. In Proceedings of International Conference on Veterinary Pharmacology, Toxicology and Therapeutics, Cambridge, England, 1980. To be published in Vet. Res. Comm

    Google Scholar 

  9. Appelgren, L.-E., Arora, R. G. and Larsson, P. (1982). Autoradiographic studies of 3H-zearalenone in mice. Toxicology, 25, 243–53

    Article  CAS  PubMed  Google Scholar 

  10. Arora, R. G. (1981). Enhanced susceptibility of weanling mice to aflatoxin B1 toxicity. Acta Pathol. Microbiol. Scand, Sect. A, 89, 303–8

    CAS  Google Scholar 

  11. Arora, R. G., Appelgren, L.-E. and Bergman, A. (1978). Distribution of [14C]-labelled aflatoxin B1 in mice. Acta Pharmacol. Toxicol, 43, 273–9

    Article  CAS  Google Scholar 

  12. Arora, R. G., Frölén, H. and Nilsson, A. (1981). Interference of mycotoxins with prenatal development of the mouse. I. Influence of aflatoxin B1, ochratoxin A and zearalenone. Acta Vet. Scand, 22, 524–34

    CAS  PubMed  Google Scholar 

  13. Arora, R. G. and Frölén, H. (1981). Interference of mycotoxins with prenatal development of the mouse. II. Ochratoxin A induced teratogenic effects in relation to the dose and stage of gestation. Acta Vet. Scand, 22, 535–52

    CAS  PubMed  Google Scholar 

  14. Bayard, F., Louvet, J. P., Ruckebusch, Y. et al (1972). Transplacental passage of dexa-methasone in sheep. J. Endocrinol, 54, 349–50

    Article  CAS  PubMed  Google Scholar 

  15. Beath, O. A., Eppson, H. F., Gilbert, C. S. et al (1939). Poisonous plants and livestock poisoning. Bull. Wyo. Agric. Exptl. Stn, 231, 1–104

    Google Scholar 

  16. Bengtsson, G. and Ullberg, S. (1963). The autoradiographic distribution pattern after administration of diethylstilboestrol compared with that of natural oestrogens. Acta Endocrinol. (Kbh.), 43, 561–70

    CAS  Google Scholar 

  17. Bengtsson, G., Ullberg, S., Wiquist, N., et al (1964). Autoradiographic studies on previable human foetuses perfused with radioactive steroids. I. Distribution of radioactive material following perfusion of progesterone-4-14C. Acta Endocrinol. (Kbh.), 46, 544–51

    CAS  Google Scholar 

  18. Biollaz, M., Buchi, G. and Milne, G. (1970). The biosynthesis of the aflatoxins. J. Am. Chem. Soc, 92, 1035–43

    Article  CAS  PubMed  Google Scholar 

  19. Blomquist, L. and Hanngren, A. (1966). Fluorescence technique applied to whole body sections for distribution studies of tetracyclines. Biochem. Pharmacol, 15, 215–19

    Article  CAS  PubMed  Google Scholar 

  20. Brandt, I. (1977). Tissue localization of polychlorinated biphenyls. Chemical structure related to pattern of distribution. Acta Pharmacol. Toxicol., 40 (Suppl. II), 1–108

    Google Scholar 

  21. Debackere, M. (1980). Poisoning of domestic animals as an indication of environmental pollution. In Van Miert, A. S. et al. (eds.) Trends in Veterinary Pharmacology and Toxicology, pp. 314–20. ( Amsterdam: Elsevier )

    Google Scholar 

  22. Dencker, L. (1976). Tissue localization of some teratogens at early and late gestation related to fetal effects. Acta Pharmacol. Toxicol., 39 (Suppl. I), 1–131

    Google Scholar 

  23. Dencker, L. (1979). Embryonic-fetal localization of drugs and nutrients. In Persaud, T. V. N. (ed.) Advances in the Study of Birth Defects. Vol. I, pp. 1–18. ( Lancaster: MTP Press )

    Google Scholar 

  24. DiPaolo, J. A., Elis, J. and Erwin, H. (1967). Teratogenic response by hamsters, rats and mice to aflatoxin B1. Nature (London), 215, 638–9

    Article  CAS  Google Scholar 

  25. Getty, S. M., Rickert, D. E. and Trapp, A. L. (1977). Polybrominated biphenyl (PBB) toxicosis: an environmental accident. CRC Crit. Rev. Environ. Control, 7, 309–23

    CAS  Google Scholar 

  26. Hanngren, Å., Hansson, E., Sjöstrand, S. E. et al (1964). Autoradiographic distribution studies with 14C-cortisone and 14C-cortisol. Acta Endocrinol. (Kbh.), 47, 95–104

    CAS  Google Scholar 

  27. Hanngren, Å., Einer. Jensen, N. and Ullberg, S. (1965). Specific uptake in corpora lutea of a non-steroid substance with anti-gestagenic properties. Nature (London), 208, 461–2

    Article  CAS  Google Scholar 

  28. Hansson, E. and Jacobsson, S. O. (1966). Uptake of [75Se]selenomethionine in the tissues of the mouse studied by whole-body autoradiography. Biochim. Biophys. Acta, 115, 285–93

    CAS  PubMed  Google Scholar 

  29. Hayes, A. W., Hood, R. D. and Lee, H. L. (1974). Teratogenic effects of ochratoxin A in mice. Teratology, 9, 93–7

    Article  CAS  PubMed  Google Scholar 

  30. Hidiroglou, M. (1980). Trace elements in the fetal and neonate ruminant: a review. Can. Vet. J, 21, 328–35

    CAS  PubMed  Google Scholar 

  31. Hsieh, D. P. H. and Mateles, R. I. (1970). The relative contribution of acetate and glucose to aflatoxin biosynthesis. Biochim. Biophys. Acta, 208, 482–6

    CAS  PubMed  Google Scholar 

  32. Hurley, L. S. and Swenerton, H. (1966). Congential malformations resulting from zinc deficiency in rats. Proc. Soc. Exp. Biol. Med, 123, 692–6

    CAS  PubMed  Google Scholar 

  33. Jacobsson, S. O. and Hansson, E. (1965). Distribution of selenium in mice studied by whole body autoradiography after injection of Se75-sodium selenite. Acta Vet. Scand, 6, 287–98

    CAS  PubMed  Google Scholar 

  34. Jacobsson, S. O. and Oksanen, H. E. (1966). The placental transmission of selenium in sheep. Acta Vet. Scand, 7, 66–76

    CAS  PubMed  Google Scholar 

  35. Van Kampen, K. R. and Ellis, L. C. (1972). Prolonged gestation in ewes ingesting Veratrum californicum: morphological changes and steroid biosynthesis in the endocrine organs of cyclopic lambs. J. Endocrinol, 52, 549–60

    Article  PubMed  Google Scholar 

  36. Keeler, R. F. (1969). Teratogenic compounds of Veratrum californicum (Durand). VII. The structure of the glycosidic alkaloid cycloposine. Steroids, 13, 579–88

    Article  CAS  PubMed  Google Scholar 

  37. Lindquist, N. G. and Ullberg, S. (1972). The melanin affinity of chloroquine and chlor- promazine studied by whole body autoradiography. Acta Pharmacol. Toxicol, 31 ( Suppl. II ), 1–32

    Google Scholar 

  38. Moré, J. and Galtier, P. (1974). Toxicite de l’ochratoxine A. I. Effet embryotoxique et teratogene chez le rat. Ann. Rech. Vet, 5, 167–78

    CAS  Google Scholar 

  39. Patterson, D. S. P., Roberts, B. A. and Small, B. J. (1976). Metabolism of ochratoxins A and B in the pig during early pregnancy and the accumulation in body tissues of ochratoxin A only. Fd. Cosmet. Toxicol, 14, 439–42

    Article  CAS  Google Scholar 

  40. Schmidt, R. E. and Panciera, R. J. (1980). Effects of aflatoxin on pregnant hamsters and hamster foetuses. J. Comp. Pathol, 90, 339–47

    Article  CAS  PubMed  Google Scholar 

  41. Stabenfeldt, G. H., Edqvist, L.-E. and Drost, M. (1975). Endocrine changes during normal and prolonged bovine pregnancy. Acta Endocrinol. (Kbh.) Suppl, 199, 385

    Google Scholar 

  42. Steele, P. A., Flint, A. P. F. and Turnball, A. C. (1976). Activity of steroid C-17,20-lyase in the ovine placenta: effect of exposure to foetal glucocorticoid. J. Endocrinol, 69, 239–46

    Article  CAS  PubMed  Google Scholar 

  43. Ullberg, S. and Bengtsson, G. (1963). Autoradiographic distribution studies with natural oestrogens. Acta Endocrinol. (Kbh.), 43, 75–86

    CAS  Google Scholar 

  44. Ullberg, S., Kristoffersson, H., Flodh, H. et al (1967). Placental passage and fetal accumulation of labelled vitamin B12 in the mouse. Arch. Int. Pharmacodyn. Ther, 167, 431–49

    CAS  PubMed  Google Scholar 

  45. Ullberg, S., Dencker, L. and Danielsson, B. (1982). The distribution of drugs and other agents in the foetus. In Snell, K. (ed.) Developmental Toxicology, pp. 123 - 163. ( London: Croom Helm )

    Google Scholar 

  46. Ványi, A., Széky, A. and Romváryne, S. E. (1974). Fusariotoxicoses. V. The effect of F2 toxin on the sexual activity of female swine. Magyar A Hat. Lapja, 11, 723–30

    Google Scholar 

  47. Vlček, Z., Nedbčlkova, J., Svobodova, R. etal. (1980). Vitamin A in the blood serum, liver, corpora lutea, placentomas, and fetal fluids of cows, and in the blood serum and liver of their fetuses in the latter third of pregnancy. Acta Vet. Brno., 49, 37–44

    Google Scholar 

  48. Volintir, V., Popescu, I., Jivanescu, I. et al (1971). Aspects of stachybotryotoxicosis and fusariotoxicosis in swine. Rev. Zootech. Med. Vet, 21, 68–78

    Google Scholar 

  49. Waddell, W. J. and Marlowe, G. C. (1976). Disposition of drugs in the fetus. In Mirkin, B. L. (ed.) Perinatal Pharmacology and Therapeutics, pp. 119 – 268. ( New York: Academic Press )

    Google Scholar 

  50. Arora, R.G., Frölén, H. and Fellner-Feldegg, H. (1983). (Accepted for publication.) (Fd. Chem. Toxicol.)

    Google Scholar 

  51. Rosenberger, G., Dirksen, G., Griinder, H. D. et al (1970). Krankheiten des Rindes. pp. 1 – 1390. ( Berlin and Hamburg: Verlag Paul Parey )

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1983 MTP Press Limited

About this chapter

Cite this chapter

Appelgren, LE. (1983). Drug disposition in the fetus. In: Ruckebusch, Y., Toutain, PL., Koritz, G.D. (eds) Veterinary Pharmacology and Toxicology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6604-8_3

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-6604-8_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6606-2

  • Online ISBN: 978-94-009-6604-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics