Skip to main content

Pharmacokinetics of albendazole, fenbendazole and oxfendazole

  • Chapter
Veterinary Pharmacology and Toxicology

Abstract

The benzimidazole anthelmintics have broad spectrum activity and are now used in many species of animals against a wide variety of helminth parasites. We believe that a study of the pharmacokinetics of these compounds could assist parasitologists in choosing more appropriate dosages and dose intervals, especially for use against some of the parasites which are more difficult to eradicate.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Duggan, D. E., Hooke, K. F. and Hwang, S. S. (1980). Kinetics of the tissue distributions of sulindac and metabolites. Drug Metab. Disp., 8, 241–6

    CAS  Google Scholar 

  2. Duncan, J. L., Armour, J., Bairden, K. et al. (1977). The activity of fenbendazole against inhibited 4th stage larvae of Ostertagia ostertagi. Vet. Rec., 101, 249

    Article  PubMed  CAS  Google Scholar 

  3. Eiler, H., Baber, W., Lyke, W. A. et al. (1981). Inhibition of gastric hydrochloric acid secretions in the rat given Ostertagia ostertagi (a gastric parasite of cattle) extract. Am. J. Vet. Res., 42, 498–502

    PubMed  CAS  Google Scholar 

  4. Jenkins, J. S. and Sampson, P. A. (1967). Conversion of cortisone to Cortisol and predni-sone to prednisolone. Br. Med. J., 2, 205–7

    Article  PubMed  CAS  Google Scholar 

  5. Marriner, S. E. and Bogan, J. A. (1981). Pharmacokinetics of fenbendazole in sheep. Am. J. Vet. Res., 42, 1146–8

    PubMed  CAS  Google Scholar 

  6. Marriner, S. E., Bogan, J. A. and Vandaele, W. (1981). Comparison of the pharmaco-kinetics of albendazole and its major metabolites after oral administration of albendazole as a suspension and as a paste formulation to sheep. Zentralbl. Veterinaermed. Reihe B., 28, 19–26

    Article  CAS  Google Scholar 

  7. McEwan, A. D. and Oakley, G. A. (1978). Anthelmintics and closure of the oesophageal groove in cattle. Vet. Rec., 102, 314–15

    Article  PubMed  CAS  Google Scholar 

  8. Morris, D. L., Dykes, P. W., Dickson, B. et al. (1983). Albendazole in hydatid disease. Br. Med. J., 286, 103–4

    Article  CAS  Google Scholar 

  9. Prichard, R. K., Hennessy, D. R. and Steel, J. W. (1970). Prolonged administration: a new concept for increasing the spectrum and effectiveness of anthelmintics. Vet. Parasit., 4, 309–15

    Article  Google Scholar 

  10. van der Bossche, H. and de Nollin, S. (1973). Effects of mebendazole on the absorption of low molecular weight nutrients by Ascaris suum. Int. J. Parasit., 3, 401–7

    Article  Google Scholar 

  11. Wagner, J. G., Di Santo, A. R., Gillespie, W. R. etal. (1981). Reversible metabolism and pharmacokinetics: application to prednisone-prednisolone. Res. Comm. Chem. Pathol. Pharmacol., 32, 387–405

    CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1983 MTP Press Limited

About this chapter

Cite this chapter

Bogan, J.A., Marriner, S.E. (1983). Pharmacokinetics of albendazole, fenbendazole and oxfendazole. In: Ruckebusch, Y., Toutain, PL., Koritz, G.D. (eds) Veterinary Pharmacology and Toxicology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6604-8_23

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-6604-8_23

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6606-2

  • Online ISBN: 978-94-009-6604-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics