Abstract
The benzimidazole anthelmintics have broad spectrum activity and are now used in many species of animals against a wide variety of helminth parasites. We believe that a study of the pharmacokinetics of these compounds could assist parasitologists in choosing more appropriate dosages and dose intervals, especially for use against some of the parasites which are more difficult to eradicate.
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References
Duggan, D. E., Hooke, K. F. and Hwang, S. S. (1980). Kinetics of the tissue distributions of sulindac and metabolites. Drug Metab. Disp., 8, 241–6
Duncan, J. L., Armour, J., Bairden, K. et al. (1977). The activity of fenbendazole against inhibited 4th stage larvae of Ostertagia ostertagi. Vet. Rec., 101, 249
Eiler, H., Baber, W., Lyke, W. A. et al. (1981). Inhibition of gastric hydrochloric acid secretions in the rat given Ostertagia ostertagi (a gastric parasite of cattle) extract. Am. J. Vet. Res., 42, 498–502
Jenkins, J. S. and Sampson, P. A. (1967). Conversion of cortisone to Cortisol and predni-sone to prednisolone. Br. Med. J., 2, 205–7
Marriner, S. E. and Bogan, J. A. (1981). Pharmacokinetics of fenbendazole in sheep. Am. J. Vet. Res., 42, 1146–8
Marriner, S. E., Bogan, J. A. and Vandaele, W. (1981). Comparison of the pharmaco-kinetics of albendazole and its major metabolites after oral administration of albendazole as a suspension and as a paste formulation to sheep. Zentralbl. Veterinaermed. Reihe B., 28, 19–26
McEwan, A. D. and Oakley, G. A. (1978). Anthelmintics and closure of the oesophageal groove in cattle. Vet. Rec., 102, 314–15
Morris, D. L., Dykes, P. W., Dickson, B. et al. (1983). Albendazole in hydatid disease. Br. Med. J., 286, 103–4
Prichard, R. K., Hennessy, D. R. and Steel, J. W. (1970). Prolonged administration: a new concept for increasing the spectrum and effectiveness of anthelmintics. Vet. Parasit., 4, 309–15
van der Bossche, H. and de Nollin, S. (1973). Effects of mebendazole on the absorption of low molecular weight nutrients by Ascaris suum. Int. J. Parasit., 3, 401–7
Wagner, J. G., Di Santo, A. R., Gillespie, W. R. etal. (1981). Reversible metabolism and pharmacokinetics: application to prednisone-prednisolone. Res. Comm. Chem. Pathol. Pharmacol., 32, 387–405
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Bogan, J.A., Marriner, S.E. (1983). Pharmacokinetics of albendazole, fenbendazole and oxfendazole. In: Ruckebusch, Y., Toutain, PL., Koritz, G.D. (eds) Veterinary Pharmacology and Toxicology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6604-8_23
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DOI: https://doi.org/10.1007/978-94-009-6604-8_23
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-6606-2
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