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Elements of Specific Recognition of Non-Intercalating Ligands in the Interaction with DNA

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Book cover Specificity in Biological Interactions

Abstract

Model studies on interactions of non-intercalating ligands with DNA have provided important information for the specific binding of proteins and DNA. The elements involved in their specific binding with DNA double helix may be used in molecular interactions of biological systems. Two classes of DNA- binding drugs, netropsin-like oligopeptides and antitumour-active compounds having quarternary ammonium structures, are discussed as representative non- intercalators.

It is documented that base pair specificity, groove binding and geometrical requirements of their interaction are related to the properties inherent in the structure and dynamics of both the interacting ligand and nucleic acid.

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Authors and Affiliations

  1. Akademie der Wissenschaften der DDR Zentralinstitut für Mikrobiologie und Experimentelle Therapie Jena, Abteilung Molekulare Biochemie, Beutenbergstr. 11, DDR 69 Jena, German Democratic Republic

    Christoph Zimmer & Gerhard Luck

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  1. Christoph Zimmer
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  2. Gerhard Luck
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Editors and Affiliations

  1. Institut de Biologie Physico-Chimique, Fondation Edmond de Rothschild, 13 rue Pierre et Marie Curie, 75005, Paris, France

    B. Pullman

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© 1984 Pontificia Academia Scientiarum — Città del Vaticano

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Zimmer, C., Luck, G. (1984). Elements of Specific Recognition of Non-Intercalating Ligands in the Interaction with DNA. In: Chagas, C., Pullman, B. (eds) Specificity in Biological Interactions. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6457-0_9

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  • DOI: https://doi.org/10.1007/978-94-009-6457-0_9

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