Abstract
A dysplastic nevomelanocytic nevus (DN) can be defined as a localized proliferation of melanocytes with cytological and architectural atypia. Synonyms for DN used in the literature include B-K mole, atypical melanocytic hyperplasia, atypical melanocytic nevus, or atypical melanocytic proliferation (1,2,3,4,5). Originally, the term DN was used for nevi with atypia associated with dermal changes exclusively in patients with the familial DN syndrome (1). More recently, it was recognized that DN may occur in patients with a history of primary cutaneous melanoma (PCM), but without evidence of the familial occurrence of PCM or DN, i.e. sporadic DN syndrome (6). The prevalence of DN in the general population is not known, but is estimated as high as 2 to 8% (7). DN are considered as precursor lesions for PCM, the lifetime risk for patients with the familial DN syndrome may approach 100% (7,8). However, PCM in these patients also may arise “de novo” from ostensibly normal skin (7). As the impact of DN on the incidence of PCM may be considerably, it is important to recognize them clinically and histologically.
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© 1984 Martinus Nijhoff Publishers, Dordrecht
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Ruiter, D.J., Bergman, W., Steylen, P.M., Scheffer, E. (1984). Histopathological Aspects of Dysplastic Nevi. In: Ruiter, D.J., Welvaart, K., Ferrone, S. (eds) Cutaneous Melanoma and Precursor Lesions. Developments in Oncology, vol 25. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6057-2_18
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DOI: https://doi.org/10.1007/978-94-009-6057-2_18
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