Summary
A guinea-pig model for induction of otitis-media by anaerobic 7 bacteria is described. Bacteroides fragilis (4–8x10 colony forming units) injected via the tympanic membrane was capable of inducing intense inflammation with persisting sequelae and survived for at least 21 days in the middle ear cavity of the animals. Propionibacterium acnes also induced otitis media although not as intense and protracted as the B.fragilis infection. The middle ear response to experimentally inoculated Peptostreptococcus anaerobius was weak and transitory.
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© 1984 Martinus Nijhoff Publishers, Dordrecht
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Thore, M., Burman, L.G., Holm, S.E. (1984). Bacteroides Fragilis, Propionibacterium Acnes and Peptostreptococcus Anaerobius in Experimental Otitis Media in Guinea-Pigs. In: Hill, M.J. (eds) Models of Anaerobic Infection. New Perspectives in Clinical Microbiology, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6054-1_4
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DOI: https://doi.org/10.1007/978-94-009-6054-1_4
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