Abstract
In clinical sepsis associated with Gram negative anaerobic rods the predominance of B. fragilis in exudate and blood suggests that it possesses some unique virulence properties. Ingham (1) has recently produced evidence of the ability of Bacteroides species to inhibit polymorph phagocytosis and killing of aerobic organisms, but the determinants responsible for this have not yet been identified. We therefore investigated the possible roles played by the lipopolysaccharide and the capsular polysaccharide of B. fragilis.
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References
Ingham HR, Sisson PR, Middleton RL. et al 1981. Phagocytosis and killing of bacteria in aerobic and anaerobic conditions. J. Med. Microbiol. 14 391–9.
Kasper DL and Seiler MW. 1975. Immunochemical characterization of the outer membrane complex of Bacteroides fragilis subspecies fragilis. J. Infect. Dis. 132 440–50.
Kasper DL. 1976. The polysaccharide capsule of Bacteroides fragilis subspecies fragilis: Immunochemical and morphological definition. J. Infect. Dis. 133 (1) 79–87.
Onderdonk AB, Kasper DL, Cisneros RL and Bartlett JG. 1977. The capsular polysaccharide of Bacteroides fragilis as a virulence factor. Comparison of the pathogenic potential of encapsulated and unencapsulated strains. J. Infect. Dis. 136 82–9.
Jones GR and Gemmell CG. 1982. Impairment by Bacteroides species of opsonisation and phagocytosis of Enterobacteria. J. Med. Microbiol. 15 351–61.
Namavar F, Verweij Am MJJ, Bal M, et al 1983. Effect of anaerobic bacteria on killing of Proteus mirabilis by human polymorphonuclear leukocytes. Infection and Immunity 40 930–5.
Tofte RW, Peterson PK, Schmeling D, et al 1980. Opsonisation of four Bacteroides species: role of the classical complement pathway and immunoglobulin. Infection and Immunity 26 784–92.
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© 1984 Martinus Nijhoff Publishers, Dordrecht
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Connolly, J.C., Tabaqchali, S. (1984). Effect of Bacteroides Fragilis Lipopolysaccharide and Capsular Polysaccharide on Polymorph Function and Serum Killing. In: Hill, M.J. (eds) Models of Anaerobic Infection. New Perspectives in Clinical Microbiology, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6054-1_10
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DOI: https://doi.org/10.1007/978-94-009-6054-1_10
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-6056-5
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