Abstract
The nature of radiation syndromes as well as the survival time following whole body irradiation are dependent on the absorbed dose. For doses in excess of several, Gy animals can die due to failure of haemopoiesis; death is observed between 10 and 20 days after irradiation. At increasing dose levels, in excess of 6 to 8 Gy, mortality is caused by irreversible damage to the gastro-intestinal tract; death occurs within approximately 6 days. The effectiveness of different types of radiation can be derived from the LD50 values for the occurrence of the two syndromes in monkeys, rats and mice as reported in the present contribution. Techniques, such as the spleen colony assay and the microscopic scoring of surviving intestinal crypt stem cells have made it possible to investigate the cellular effects inducing the clinical syndromes.
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References
Bond V.P., Fliedner, T.M. and Archambeau, J.V. 1965 Mammalian Radiation Lethality (New York: Academic Press).
Broerse J.J. 1969, Dose-mortality studies for mice irradiated with X-rays, gamma-rays and 15 MeV neutrons. Int. J. Radiat. Biol, 15, 115.
Broerse J.J. 1974, Review of RBE values of 15 MeV neutrons for effects on normal tissues. Europ. J. Cancer 10, 225
Broerse J.J., Engels A.C., Lelieveld P. Putten L.M. van, Duncan W, Greene D., Massey J.B., Gilbert C.W., Hendry J.H., and Howard A., 1971, The survival of colony-forming units in mouse bone marrow after in vivo irradiation with D-T neutrons, X- and gamma-radiation. Int. J. Radiat. Biol., 19, 101
Broerse J.J., Barendsen G.W., Freriks G. and Putten L.M. van, 1971, RBE values of 15 MeV neutrons for effects on normal tissues. Europ. J. Cancer. 7, 171.
Broerse J.J., Barendsen G.W., Gaiser J.F. and Zoetelief J., 1977. The importance of differences in intrinsic cellular radio sensitivity for the effectiveness of neutron radiotherapy treatments. In: Radiobiological Research and Radiotherapy (Vienna: International Atomic Energy Agency) II, 19.
Broerse J.J., Bekkum D.W. van, Hollander C.F. and Davids J.A.G., 1978. Mortality of monkeys after exposure to fission neutrons and the effect of autologous bone marrow transplantation. Int. J. Radiat. Biol. 34, 253
Davids J.A.G., 1970. Bone-marrow syndrome in CBA mice exposed to fast neutrons of 1.0 MeV mean energy. Effect of syngeneic bone-marrow transplantation. Int. J. Radiat. Biol. 17, 878
Dutreix J., Gluckman E., Brule J.M., 1982. Biological problems of total body irradiation. J.Eur. Radiother. 3, 165
Hendry J.H., Greene D., 1976. Re-evaluation of published neutron RBE values for mouse intestine. Brit. J, Radiol., 49, 195
Hornsey S., Vatistas S., Bewley D.K. and Parnell C.J., 1965. The effect of fractionation on four-day survival of mice after whole-body neutron irradiation. Brit. J. Radiol. 38, 878.
Putten L.M. van, Lelieveld P. and Broerse J.J., 1970. Effects of 300kV X-rays and 15 MeV neutrons in single and fractionated doses on hemopoietic stem cells in mouse bone marrow. In: Proc. Conf. Time and Dose Relationships in Radiation Biology as Applied to Radiotherapy. (Springfield: NBS), 162
Till J.E. and McCulloch E.A., 1961. Direct measurement of radiation sensitivity of normal mouse bone marrow cells. Radiat Res. 14, 213.
Vriesendorp H.M. and Bekkum D.W. van, 1980. Role of total body irradiation in conditioning for bone marrow transplantation. In: Immunology of Bone Marrow Transplantation. (Berlin: Springer Verlag), 349.
Withers H.R. and Elkind M.M., 1970. Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation. Int. J. Radiat. Biol. 17, 261
Zijwietz F., Jung H., Hess A. and Franke H.I., 1979. Response of mouse intestine to 14 MeV neutrons. Int. J. Radiat. Biol. 35, 63.
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© 1984 Martinus Nijhoff Publishers, Dordrecht
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Broerse, J.J., Zoetelief, J. (1984). The Occurrence of Radiation Syndromes in Rodents and Monkeys in Dependence on Dose Rate and Radiation Quality. In: Response of Different Species to Total Body Irradiation. Series in Radiology, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6048-0_11
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DOI: https://doi.org/10.1007/978-94-009-6048-0_11
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