Capture Assays for the Detection of Virus-Specific IgM Antibody

  • Richard S. Tedder
Part of the Current Topics in Veterinary Medicine and Animal Science book series (CTVM, volume 29)


Class-specific antibody capture assays have been developed for a number of human virus infections, in particular for the detection of IgM antibody. These assays, MACRIA’s, have a number of advantages over the more conventional indirect solid-phase immunoassays. They are sensitive and unaffected by rheumatoid factor and particularly suited to detecting specific IgM in sera from neonates. While veterinarians will need to develop species-specific anti-μFc antisera, the compensation is that once this is done, the pair of appropriately balanced reagents, virus antigen and its labelled antibody, will be suitable to diagnose recent infection by a given virus in any animal species.


Rheumatoid Factor Capture Assay Rubella Virus Infection Single Dilution Indirect Immunoassay 
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Copyright information

© ECSC, EEC, EAEC, Brussels-Luxembourg 1984

Authors and Affiliations

  • Richard S. Tedder
    • 1
  1. 1.Department of Virology (Microbiology), School of PathologyMiddlesex Hospital Medical SchoolLondonUK

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