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The Induction of Fetal Lung Maturation

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Critical Care of the Child

Part of the book series: Developments in Critical Care Medicine and Anesthesiology ((DCCA,volume 8))

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Abstract

Respiratory distress syndrome of the newborn (RDS) is due to immaturity of the lungs at birth, particularly the surfactant system. The considerable mortality and morbidity associated with this condition has focused attention on the regulation of fetal lung development.

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References

  1. Gross I: The hormonal regulation of fetal lung maturation. Clin Perinatol 6:377–395, 1979

    PubMed  CAS  Google Scholar 

  2. Liggens GC: Premature delivery of foetal lambs infused with glucocorticoids. J Endocrinol 45:515–523, 1969

    Article  Google Scholar 

  3. Ballard PL, Mason RJ, Douglas WHJ: Glucocorticoid binding by isolated lung cells. Endocrinology 102:1570–1575, 1978

    Article  PubMed  CAS  Google Scholar 

  4. Gross I, Wilson CM, Ingleson LD, Brehier A, Rooney SA: Fetal lung in organ culture. III. Comparison of dexamethasone, thyroxine and methylxanthines. J Appl Physiol 48:872–877, 1980

    PubMed  CAS  Google Scholar 

  5. Gross I, Ballard PL, Ballard RA, Jones CT, Wilson CM: Corticosteroid stimulation of phosphatidylcholine synthesis in cultured fetal rabbit lung. Evidence for de novo protein synthesis mediated by glucocorticoid receptors. Endocrinoloy 112:829–837, 1983

    Article  CAS  Google Scholar 

  6. Liggens GC, Howie RN: A controlled trial of antepartum glucocorticoid treatment for prevention of respiratory distress syndrome in premature infants. Pediatrics 50:515–524, 1972

    Google Scholar 

  7. Collaborative group on antenatal steroid therapy: Effect of antenatal dexamethasone administration on the prevention of respiratory distress syndrome. Am J Obstet Gynecol 141:276–286, 1981

    Google Scholar 

  8. MacArthur BA, Howie RN, Dezoete JA, Elkins J: School progress and cognitive development of 6-year old children whose mothers were treated antenatally with betamethasone. Pediatrics 70:99–105, 1982

    PubMed  CAS  Google Scholar 

  9. Masters JR: Epithelial mesenchymal interaction during lung development: the effect of mesenchymal mass. Devel Biol 51:98–108, 1976

    Article  CAS  Google Scholar 

  10. Smith BT: Lung maturation in the fetal rat: acceleration by injection of fibroblast-pneumonocyte factor. Science 204:1094–1095, 1979

    Article  PubMed  CAS  Google Scholar 

  11. Ballard PL, Benson BJ, Brehier A, Carter JP, Kriz BM, Jorgensen EL: Transplacental stimulation of lung development in the fetal rabbit by 3,5-dimethyl-3′isopropyl-L-thyronine. J Clin Invest 65:1407–1417, 1980

    Article  PubMed  CAS  Google Scholar 

  12. Lindenberg JA, Brehier A, Ballard PL: Triodothyronine nuclear binding in fetal and adult rabbit lung and cultured lung cells. Endocrinology 103:1725–1731, 1978

    Article  PubMed  CAS  Google Scholar 

  13. Rooney SA, Marino PA, Gobran LI, Gross I, Warshaw JB: Thyrotropin-releasing hormone increases the amount of surfactant in lung lavage from fetal rabbits. Pediatr Res 13:623–625, 1979

    Article  PubMed  CAS  Google Scholar 

  14. Mashiach S, Barkai G, Sack J, Stern E, Goldman B, Brish M, Serr DM: Enhancement of fetal lung maturity by intra-amniotic administration of thyroid hormone. Am J Obstet Gynecol 130:289–293, 1978

    PubMed  CAS  Google Scholar 

  15. Robert MF, Neff RK, Hubbell JP, Taeusch HW, Avery ME: Association between maternal diabetes and the respiratory-distress syndrome in the newborn. N Engl J Med 294:357–360, 1976

    Article  PubMed  CAS  Google Scholar 

  16. Gross I, Smith GJW, Wilson CM, Maniscalco WM, Ingleson LD, Brehier A, Rooney SA: The influence of hormones on the biochemical development of fetal rat lung in organ culture. II. Insulin. Pediatr Res 14:834–838, 1980

    CAS  Google Scholar 

  17. Smith BT, Giroud CJP, Robert M, Avery ME: Insulin antagonism of Cortisol action on lecithin synthesis by cultured fetal lung cells. J Pediatr 87:953–955, 1975

    Article  PubMed  CAS  Google Scholar 

  18. Maniscalco WM, Wilson CM, Gross I, Gobran L, Rooney SA, Warshaw JB: Development of glycogen and phospholipid metabolism in fetal and newborn rat lung. Biochim Biophys Acta 530:333–346, 1978

    PubMed  CAS  Google Scholar 

  19. Dobbs LG, Mason RJ: Pulmonary alveolar type II cells isolated from rats. Release of phosphatidylcholine in response to β-adrenergic stimulation. J Clin Invest 63:378–387, 1979

    Article  PubMed  CAS  Google Scholar 

  20. Cheng JB, Goldfien A, Ballard PL, Roberts JM: Glucocorticoids increase pulmonary β-adrenergic receptors in fetal rabbit. Endocrinology 107:1646–1648, 1980

    Article  PubMed  CAS  Google Scholar 

  21. Whitsett JA, Darovec-Beckerman C, Adams K, Pollinger J, Needleman H: Thyroid dependent maturation of ß-adrenergic receptors in the rat lung. Biochem Biophys Res Commun 97:913–917, 1980

    Article  PubMed  CAS  Google Scholar 

  22. Corbet AJS, Flax P, Rudolph AJ: Reduced surface tension in lungs of fetal rabbits injected with pilocarpine. J Appl Physiol 41:7–14, 1976

    PubMed  CAS  Google Scholar 

  23. Khosla SS, Rooney SA: Stimulation of fetal lung surfactant production by administration of 17 β-estradiol to the maternal rabbit. Am J Obstet Gynecol 133:213–216, 1979

    PubMed  CAS  Google Scholar 

  24. Gross I, Wilson CM, Ingleson LD, Brehier A, Rooney SA: The influence of hormones on the biochemical development of fetal rat lung in organ culture. I.Estrogen.Biochim Biophys Acta 575:375–383, 1980

    Google Scholar 

  25. Mendelson CR, MacDonald PC, Johnston JM: Estrogen binding in human fetal lung tissue cytosol. Endocrinology 106:368–374, 1980

    Article  PubMed  CAS  Google Scholar 

  26. Hauth JC, Parker CR, MacDonald PC, Porter JC, Johnston JM: A role of fetal prolactin in lung maturation. Obstet Gynecol 51:81–88, 1978

    PubMed  CAS  Google Scholar 

  27. Hamosh M, Hamosh P: The effect of prolactin on the lecithin content of fetal rabbit lung. J Clin Invest 59:1002–1005, 1977

    Article  PubMed  CAS  Google Scholar 

  28. Ballard PL, Gluckman PD, Brehier A, Kitterman JA, Kaplan SL, Rudolph AM, Grumbach MM: Failure to detect an effect of prolactin on pulmonary surfactant and adrenosteroids in fetal sheep and rabbits. J Clin Invest 62:879–883, 1978

    Article  PubMed  CAS  Google Scholar 

  29. Gross I, Wilson CM: Fetal lung in organ culture. IV. Supra additive hormone interactions. J Appl Physiol 52:1420–1425, 1982

    PubMed  CAS  Google Scholar 

  30. Smith BT, Sabry K: Glucocorticoid-thyroid synergism in lung maturation: mechanism involving epithelial-mesenchymal interaction. Proc Natl Acad Sci USA 80:1951–1954, 1982

    Article  Google Scholar 

  31. Gross I, Dynia DW, Wilson CM, Ingleson LD, Gewolb IH, Rooney SA: Glucocorticoid-thyroid hormone interactions in fetal rat lung. Pediatr Res 18:191–196, 1984

    Article  PubMed  CAS  Google Scholar 

  32. Gross I, Wilson CM: Fetal lung maturation. Initiation and modulation. J Appl Physiol 55:1725–1732, 1983

    PubMed  CAS  Google Scholar 

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Authors
  1. Ian Gross
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Editor information

Editors and Affiliations

  1. Thoraxcentrum Academic Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands

    O. Prakash MD

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© 1984 Martinus Nijhoff Publishers, Dordrecht

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Gross, I. (1984). The Induction of Fetal Lung Maturation. In: Prakash, O. (eds) Critical Care of the Child. Developments in Critical Care Medicine and Anesthesiology, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6036-7_2

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  • DOI: https://doi.org/10.1007/978-94-009-6036-7_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6038-1

  • Online ISBN: 978-94-009-6036-7

  • eBook Packages: Springer Book Archive

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