Abstract
This contribution reviews the cellular kinetics of the migratory blood cells, i.e. those cells in the blood of human beings that are in transit from one part of the organism to another, usually from the site of production to the site of emigration or removal (as in the case of granulocytes), but also from the site of transitory residence to another site of transitory residence (as in the case of “recirculating” lymphocytes). In the first part of this review, the principal functional structure of cell renewal systems is outlined in order to show that each migratory blood cell originates from a particular cell system that is under continuous renewal and guarantees a dynamic equilibrium between cell production and cell removal under the conditions of the normal steady state. In the second part of this presentation, data will be summarized to indicate, that each type of migratory blood cell has its own particular characteristics considering origin, migratory properties and destination.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Stohlman F., Jr. (Ed.): The Kinetics of Cellular Proliferation. Grime and Stratton, New York, 1959.
Cronkite E.P., T.M. Fliedner, V.P. Bond, J.R. Rubini and W.L. Hughes: Dynamics of the proliferating cell systems of man studied with tritiated thymidine. J. Clin. Invest. 37:887, 1958.
Athens J.W. et al.: A method for labeling leukocytes with di iso propylfluorophosphate (32-P-DFP). Blood 14:303–333, 1959.
Cuttner J.W., E.P. Cronkite, M. Kesse and T.M. Fliedner: Behaviour of autotransfused in vitro 3-H-cytidine labeled lymphocytes in chronic lymphocytic leukemia. J. Clin. Invest. 43:1236, 1964.
Bremer K. and T.M. Fliedner: RNA metabolism of circulating lymphocytes studied in man after autotransfusion and in-vitro 3-H-cytidine labeling. Acta haematol. (Basel) 45:181, 1971.
Meuret G., G. Hoffmann, T.M. Fliedner, M. Rau, S. Oehl, R. Walz and Klein-Wisenberg, A. v.: Neutrophil kinetics in man. Studies using autotransfusion of 3-H-DFP labelled blood cells and autoradiography. Blut 25:97–109, 1973.
Winthrobe M.M. (Ed.): Clinical hematology. Lea and Febiger, Philadelphia, 1981.
Thakur M.L.: Cell Labeling: Achievements, Challenges, and Prospects. J. Nucl. Med. 22:1011–1014, 1982.
Kelemen E., W. Calvo and T.M. Fliedner (Eds.): Atlas of Human Hemopoietic Development. Springer Verlag Berlin, Heidelberg, New York, 1979.
Fliedner T.M., K.H. Steinbach and D. Hoelzer: Adaptation to environmental changes: The role of cell-renewal systems. In: The effects of environment on cells and tissues, edited by E.S. Finckh and E. Clayton-Jones. Excerpta Medica, Amsterdam-Oxford, pp. 20/38, 1976.
Metcalf D. (Ed.): Hemopoietic colonies. Springer Verlag Berlin, Heidelberg, New York (Recent Results in Cancer Research, Vol. 61), 1977.
Fliedner T.M., E.P. Cronkite, S.A. Hillman and V.P. Bond: Granulocytopoiesis II. Emergence and Pattern of labeling of neutrophilic granulocytes in human beings. Blood 24:683–700, 1964.
Bessis M.: Living blood cells and their ultrastructure. Springer-Verlag Berlin, Heidelberg, New York, 1973.
Meuret G., J. Bammert and G. Hoffmann: Kinetics of human monocytopoiesis. Blood 44:801–816, 1974.
Theml H. and H. Begemann (Eds.): Lymphozyt und klinische Immunologie. Springer Verlag Berlin, Heidelberg, New York, 1975.
Schiffer L.M.: Kinetics of chronic lymphocytic leukemia. Ser. Hematol. 1:3, 1968.
Bremer K., P. Schick, O. Wack, H. Theml, B. Brass and H. Heimpel: Rezirkulation von Lymphozyten bei Patienten mit malignen lymphatischen Systemerkrankungen. Blut 24:215, 1972.
Queisser W. (Ed.): Das Knochenmark. Georg Thieme Verlag, Stuttgart, 1978.
Zwaan F.E.: Haemopoietic Progenitor Cells in Peripheral Blood. Blut 45:87–95, 1982.
Barr R.D. and J.A. McBride: Haemopoietic engraftment with peripheral blood cells in the treatment of malignant disease. Br. J. Haemat. 51:181–187, 1982.
Ford C.E., J.L. Hamerton, D.W.H. Barnes and J.F. Loutit: Cytological identification of radiation-chimaeras.
Till J.E. and E.A. McCulloch: A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiation Research 14:213–222, 1961.
Fliedner T.M., W. Calvo, M. Koerbling, W. Nothdurft, H. Pflieger and W. Ross: Collection, Storage and Transfusion of Blood Stem Cells for the Treatment of Haemopoietic Failure. Blood Cells 5:313–328, 1979.
Fliedner T.M., U.B. Wandl and W. Calvo: Medullaere und extramedullaere Haemopoiese im Hund nach Ganzkoerperbestrahlung und Transfusion von aus dem Blut gewonnenen Stammzellen. Schweiz. med. Wschr. 112:1423–1429, 1982.
Stutman O. and R.A. Good: Heterogeneity of lymphocyte populations. Rev. Europ. Etudes Clin. Biol. 17:11, 1972.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Martinus Nijhoff Publishers, The Hague
About this chapter
Cite this chapter
Fliedner, T.M. (1984). Physiology and Pathophysiology of Migratory Blood Cells. In: Fueger, G.F. (eds) Blood cells in nuclear medicine, part II. Developments in Nuclear Medicine, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6030-5_3
Download citation
DOI: https://doi.org/10.1007/978-94-009-6030-5_3
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-6032-9
Online ISBN: 978-94-009-6030-5
eBook Packages: Springer Book Archive