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Radiation Dosimetry of Labelled Leucocytes

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Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 7))

Abstract

The most important clinical application of labelled white blood cells (WBC) is the identification and localization of abscesses and inflammatory processes by scintigraphy after the injection of 111-In labelled autologous leucocytes (1,2). Lymphocytes labelled with 111-In are now also used for studies of lymphocyte migration and distribution in man (3). 99m-Tc has also been used for leucocyte labelling (4–9). Earlier fundamental studies on blood cell kinetics were performed with the use of 32-P-DFP (10). 51-Cr has also been employed in non-imaging applications such as cell kinetic studies etc. (11).

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References

  1. Thakur M.L., J.P. Lavender, R.N. Arnot, et al: Indium-111- labeled autologous leucocytes in man. J. Nucl. Med. 18:1012–1019, 1977.

    Google Scholar 

  2. Thakur M.L. and A. Gottschalk (Eds.): Indium-111 Labeled Neutrophils, Platelets, and Lymphocytes. Trivirum Publising Company, New York, 1980.

    Google Scholar 

  3. Chisholm P.M. and A.M. Peters: The effect of indium-111 labeling on the recirculation of rat lymphocytes. In: Indium-111 labeled Neutrofils, Platelets, and Lymphocytes, edited by M.L. Thakur and A. Gottschalk, pp.205–208. Trivirum Publishing Company, New York, 1980.

    Google Scholar 

  4. Uchida T. and S. Kariyone: Organ distribution of the Tc-99m labeled white cells. Acta Haematol. Jpn. 36:78–81, 1973.

    CAS  Google Scholar 

  5. Uchida T. and P.C. Vincent: In vitro studies of leukocyte labeling with technetium-99m. J. Nucl. Med. 17:730–736, 1976.

    PubMed  CAS  Google Scholar 

  6. English D. and B.R. Andersen: Labeling of phagocytes from human blood with Tc-99m-sulfur colloid. J. Nucl. Med. 16:5–10, 1975.

    PubMed  CAS  Google Scholar 

  7. English D. and B.R. Andersen: Organ distribution of canine leukocytes labeled with Tc-99m-sulfur colloid. J. Nucl. Med. 18:289–295, 1977.

    PubMed  CAS  Google Scholar 

  8. Linhardt N., B. Bok, M. Gougerot, M.T. Gaillard and M. Meignan: Tc-99m labelled human leukocytes. An in vitro functional study. Acta Haemat. 63:71–80, 1980.

    Article  Google Scholar 

  9. Schroth H.J., E. Oberhausen and R. Berberich: Cell labelling with colloidal substances in whole blood. Eur. Nucl. Med. 6: 469–472, 1981.

    CAS  Google Scholar 

  10. Athens J.W., O.P. Haab, O.S. Raab, A.M. Mauer, H. Ashen-brucker, G.E. Cartwright and M.M. Wintrobe: Leukokinetic studies IV. The total blood, circulating and marginal granulocyte pools and the granulocyte turnover rate in normal subjects. J. Clin. Invest. 40:989–995, 1961.

    Article  PubMed  CAS  Google Scholar 

  11. Dresch C. and Y. Najean: Etude de la cinetique des polynucleaires apres marquage in vitro par le radiochrome. I. Etude critique de la methode et resultats obtenus chez les sujets normaux. Nouv. Rev. Franc. Hemat. 7:27–48, 1967.

    PubMed  CAS  Google Scholar 

  12. Roevekamp M.H.: Indium-111 labelled leucocyte scintigraphy in the diagnosis of inflammatory disease. Thesis, Univ. Amsterdam, 1982.

    Google Scholar 

  13. Sinn H. and D.J. Silvester: Simplified cell labelling with Indium-111 acetylacetone. Br. J. Radiol. 52:758–759, 1979.

    Article  PubMed  CAS  Google Scholar 

  14. Danpure H.J., S. Osman and F. Brady: The labelling of blood cells in plasma with In-111 tropolonate. Br. J. Radiol. 55:247–249, 1982.

    Article  PubMed  CAS  Google Scholar 

  15. Zakhireh B., M.L. Thakur, M.L. Malech, et al: Indium-111-labeled human polymorphonuclear leucocytes: viability, random migration, Chemotaxis, bactericidal capacity, and ultrastructure. J. Nucl. Med. 20:741–747, 1979.

    PubMed  CAS  Google Scholar 

  16. Weiblen B.J., L. Forstrom and J. McCullough: Studies of the kinetics of indium-111-labeled granulocytes. J. Lab. Clin. Med. 94:246–255, 1979.

    PubMed  CAS  Google Scholar 

  17. Goodwin D.A., R.A. Finston and S.I. Smith: The distribution and dosimetry of In-111 labeled leucocytes and platelets in humans. Proceedings Third International Dosimetry Radio- pharmaceutical Symposium, pp.88–101. Oak Ridge, 1980.

    Google Scholar 

  18. Sokole-Buseman E., D. Hengst and M.H. Roevekamp: Radiation dosimetry of In-111 oxinate labelled leucocytes. Symposium on blood cell labelling, pp.14–16. Nucleair Geneeskundig Bulletin I. 4 suppl., 1982. (Sokole-Buseman E.: Personal communication, 1982.)

    Google Scholar 

  19. Fueger G.F.: Personal communication, 1982.

    Google Scholar 

  20. Olsson P.I.: Personal communication.

    Google Scholar 

  21. Linhardt-Colas N., M. Meignan, B. Bok, et al: In vivo kinetics of 99m-technetium labelled leucocytes in dogs and the effects of an abscess. Biomedicine 32:133–139, 1980.

    Google Scholar 

  22. McAfee G.M., G.G. Subramanian, Z.D. Grossman, F.D. Thomas, M.L. Roskopf, P. Fernandes and B.J. Lyons: Distribution of leucocytes labeled with In-111 oxine in dogs with acute inflammatory lesions. J. Nucl. Med. 21:1059–1068, 1980.

    PubMed  CAS  Google Scholar 

  23. Van Reenen O.R., M.G. Loetter, P.C. Minnaar, A.P. Heyns, P.N. Badenhorst and H. Pieters: Radiation dose from human platelet labelled with indium-111. Br. J. Radiol. 53: 790–795, 1980.

    Article  PubMed  Google Scholar 

  24. Klonizakis I., A.M. Peters, M.L. Fitzpatrick, M.J. Kensett, S.M. Lewis and J.P. Lavender: Radionuclide distribution following injection of 111-indium labelled platelets. Br. J. Haematol. 46:595–602, 1980.

    Article  PubMed  CAS  Google Scholar 

  25. Peters A.M., I. Klonizakis, J.P. Lavender and S.M. Lewis: Use of 111-indium labelled platelets to measure spleen function. Br. J. Haematol. 46:587–593, 1980.

    Article  PubMed  CAS  Google Scholar 

  26. Snyder W.S., M.R. Ford, G.G. Warner and S.B. Watson: Absorbed dose per unit cumulated activity for selected radionuclides and organs, “S” (MIRD) Pamphlet No. 11, 1975.

    Google Scholar 

  27. ICRP publication 26. Recommendation of the International Commission on Radiological Protection. Pergamon Press, Oxford, 1977.

    Google Scholar 

  28. Bjurman B., L. Johansson and S. Mattsson: In-114m in In-111 radiopharmaceuticals and its contribution to the absorbed dose in the patient at investigations with In-111 labeled blood cells. Proc. Third World Congress of Nuclear Medicine and Biology, Paris, Aug.29–Sept.2, 1982, pp.2403–2406, 1982.

    Google Scholar 

  29. Silvester D.J.: Consequences of Indium-111 decay in vivo: Calculated absorbed radiation dose to cells labelled by Indium-111 oxine. J. Lab. Comp. Radiopharm. 16:193–194, 1979.

    Google Scholar 

  30. Danpure H.J. and S. Osman: Cell labelling and cell damage with Indium-111 acetylacetone — an alternative to indium-111 oxine. Br. J. Radiol. 54:597–601, 1981.

    Article  PubMed  CAS  Google Scholar 

  31. Ten Berge R.F.M., A.T. Natarajan, S.L. Yong, et al: Labelling of human lymphocytes with In-111 oxinate. Symposium on blood cell labelling, pp.18–20. Nucleair Geneeskundig Bulletin 4, Suppl., 1982.

    Google Scholar 

  32. Subramanian G., J.G. McAfee, G.M. Gagne, R.W. Henderson and M. Rosenstreich: 99mTc-Oxine: A New Lipophilic Radiopharma-ceutical for Labeling Leukocytes and Platelets. Proc. 14th Internat. Meeting of the Soc. of Nucl. Med., Berlin, 1976.

    Google Scholar 

  33. Spitznagle L.A., C.A. Marino and S. Kasina: Lipophilic chelates of technetium-99m: Tropolone. J. Nucl. Med. 22: PB, 1981.

    Google Scholar 

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© 1984 Martinus Nijhoff Publishers, The Hague

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Bjurman, B. et al. (1984). Radiation Dosimetry of Labelled Leucocytes. In: Fueger, G.F. (eds) Blood cells in nuclear medicine, part II. Developments in Nuclear Medicine, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6030-5_15

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  • DOI: https://doi.org/10.1007/978-94-009-6030-5_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6032-9

  • Online ISBN: 978-94-009-6030-5

  • eBook Packages: Springer Book Archive

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