111-In-Labelled White Blood Cells: Biodistribution and Techniques of In-Vivo Quantification

Abstract

The normal organ and tissue distribution of neutrophil leucocytes is still largely unknown (1). Although the organ and tissue localization of 111-In observed with a scintillation camera may be due not only to viable neutrophils, but to damaged cells, protein bound 111-In-oxinate or 111-In-transferrin, or a combination of these (1), the quantification of the biological distribution of the 111-In activity appears desirable if for no other reason but dosimetric considerations. This work analyzes the activity distribution after injection of 111-In labelled mixed white cell preparations in humans using a scintillation camera and an associated computer. Such equipment is widely available, and it appears better to obtain quantitative approximations now than to wait until equipment of theoretical superiority might become available at some later time. Conjugate scintimetry was used as the method of quantification, as described in the preceding chapter.