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Megakaryocytic Precursors

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Blood cells in nuclear medicine, part I

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 6))

Abstract

The recent developments of both culture techniques, determination of differentiation antigens by monoclonal antibodies and cytochemistry has permitted to define several classes of megakaryocytic precursors in murine and human species.

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References

  1. Levine RF, Hazzard KC, Lamberg JD, The significance of megakaryocyte size. Blood 60: 1122, 1982.

    PubMed  CAS  Google Scholar 

  2. Zajicek J, Studies on the histogenesis of blood platelets and megakaryocytes. Acta Physiol. scand. 40:138, 1957 (suppl).

    Google Scholar 

  3. Karnosysky MJ, Roots L, A direct coloring thiocholine method for cholinesterases. J. Histochem. Cytochem. 12: 219, 1964.

    Article  Google Scholar 

  4. Jackson CW, Cholinesterase as a possible marker for early cells of the megakaryocytic series. Blood 42: 413, 1973.

    PubMed  CAS  Google Scholar 

  5. Long MW, Williams N, Ebbe S, Immature megakaryocytes in the mouse. Physical characteristics, cell cycle status and in vitro responsiveness to thrombopoietic stimulating factor. Blood 59: 569, 1982.

    PubMed  CAS  Google Scholar 

  6. Long MW, Henry RL, Thrombocytosis induced suppression of small acetyl-cholinesterase positive cells in bone marrow of rats. Blood 54: 1338, 1979.

    PubMed  CAS  Google Scholar 

  7. Kalmaz GD, McDonald TP, Effects of antiplatelet serum and thrombopoietin on the percentage of small acetylcholinesterase-positive cells in bone marrow of mice. Exp. Heurat. 9: 10002, 1981.

    Google Scholar 

  8. Breton-Gorius J, Guichard J, Ultrastructural localization of peroxidase activity in human platelets and megakaryocytes. Amer. J. Path. 66: 277, 1972.

    PubMed  CAS  Google Scholar 

  9. Breton-Gorius J, Reyes F, Ultrastructure of human bone marrow cell maturation. Int. Rev. Cytol. 46: 251, 1976.

    Article  PubMed  CAS  Google Scholar 

  10. Breton-Gorius J, Megakaryoblastic leukemia. Hematologica 64: 517, 1979.

    CAS  Google Scholar 

  11. Rabellino EM, Nachman RL, Williams N, Winchester RJ, Ross GD, Human megakaryocytes. I. Characterization of the membranes and cytoplasmic components of isolated marrow megakaryocytes. J. exp. Med. 149: 1273, 1979.

    CAS  Google Scholar 

  12. Rabellino E, Levine RB, Leung LLK, Nachman RL Human megakaryocytes II. Expression of platelet proteins in early marrow megakaryocytes. J. exp. Med. 154: 88, 1981.

    Article  PubMed  CAS  Google Scholar 

  13. Mazur DM, Hoffman R, Chasis J, Marchesi S, Bruno E, Inmunofluorescent identification of human megakaryocyte colonies using an antiplatelet glycoprotein antisera. Blood 57: 277, 1981.

    PubMed  CAS  Google Scholar 

  14. Vainchenker W, Deschamps JF, Bastin JM, Guichard J, Titeux M, Breton Gorius J, McMichael AJ, Two monoclonal antiplatelet antibodies as markers of human megakaryocyte maturation. Immunofluorescent staining and platelet peroxidase detection in megakaryocyte colonies and in vivo cells from normal and leukemic patients. Blood 59: 514, 1982.

    PubMed  CAS  Google Scholar 

  15. Nachman R, Levine R, Jaffe EA, Synthesis of factor VIII antigen by cultured guinea pig megakaryocytes. J. clin. Invest. 60: 914, 1977.

    Article  PubMed  CAS  Google Scholar 

  16. Vinci G, Tabilio A, Deschamps JF, Henri A, Vainchenker W, BretonGorius J, Immunological phenotype of cultured human megakaryocytes. In preparation.

    Google Scholar 

  17. Schick PK, Weinstein M, A marker for megakaryocytes: serotonin accumulation-in guinea pig megakaryocytes. J. Lab. clin. Med. 98: 607, 1981.

    PubMed  CAS  Google Scholar 

  18. Breton-Gorius J, Vanhaeke D, Tabilio A, Vainchenker W, Deschamps JF, Xu FS, Glycoprotein I. Identification during normal and pathological megakaryocytic maturation. Blood Cells, 1983 (in press).

    Google Scholar 

  19. Long MW, Williams N, McDonald TP, Immature megakaryocytes in the mouse; in vitro relationship to megakaryocyte progenitor cells and mature megakaryocytes. J. Cell. Physiol. 112: 339, 1982.

    Article  PubMed  CAS  Google Scholar 

  20. Vainchenker W, Tabilio A, Vinci G, Clauvel JP, Breton-Gorius J, Megakaryocyte precursors in ITP: Influence of treatment. In preparation.

    Google Scholar 

  21. Nakeff A, Dicke KA, Van Noord MJ, Megakaryocytes in agar cultures of mouse bone marrow. Ser. Haemat. 8: 4, 1975.

    CAS  Google Scholar 

  22. Metcalf D, McDonald HR, Odartchenko N, Sordat B, Growth of mouse megakaryocyte colonies in vitro. Proc. nat. Acad. Sci. USA, 72: 1744, 1975.

    Article  PubMed  CAS  Google Scholar 

  23. Vainchenker W, Guichard J, Breton-Gorius J, Growth of human megakaryocyte colonies in culture from fetal, neonatal and adult peripheral blood cells. Ultrastructural analysis. Blood Cells, 5: 25, 1979.

    PubMed  CAS  Google Scholar 

  24. Kantz L, Straub G, Bross KG, Fauser AA, Identification of human megakaryocytes derived from pure megakaryocytic colonies (CFU-M), megakaryocytic/erythroid colonies (CFU/M/E) and mixed hemopoietic colonies (CFU-CEMM) by antibodies against platelet associated antigens. Blut, 45: 267, 1982.

    Article  Google Scholar 

  25. Levin J, Levin FC, Metcalf D, The effects of acute thrombocytopenia on megakaryocyte-CFC and granulocyte macrophage-CFC in mice. Studies of bone marrow and spleen. Blood 56: 274, 1980.

    PubMed  CAS  Google Scholar 

  26. Nakeff A, Daniels-McQueen S, In vitro colony assay for a new class of megakaryocyte precursor. Colony forming unit megakaryocyte (CFU-M). Proc. Soc. exp. Biol. Med. 151:587, 1976.

    PubMed  CAS  Google Scholar 

  27. Burstein SA, Adamson JW, Thorning D, Harker LA, Characteristics of murine megakaryocytic colonies in vitro. Blood 54: 169, 1979.

    PubMed  CAS  Google Scholar 

  28. Mizoguchi H, Kubota K, Miura Y, Takaku F, An improved plasma culture system for the production of megakaryocyte colonies in vitro. Exp. Hemat. 7: 345, 1979.

    PubMed  CAS  Google Scholar 

  29. Williams N, Jackson H, Sheridan APC, Murphy MJ Jr, Elsta A, Moore MAS, Regulation of megakaryopoiesis in longterm murine bone marrow cultures. Blood 51: 245, 1978.

    PubMed  CAS  Google Scholar 

  30. McLeod DL, Shreeve MM, Axelrad AA, Induction of megakaryocyte colonies with platelet formation in vitro. Nature 261: 492, 1976.

    Article  PubMed  CAS  Google Scholar 

  31. Dukes PP, Izadi P, Ortega JA, Shore NA, Gomperts E, Inhibitory effects of interferon on mouse megakaryocytic progenitor cells in culture. Exp. Hemat. 8: 1048, 1980.

    PubMed  CAS  Google Scholar 

  32. Freedman MH, McDonald TP, Saunders EF, Differentiation of murine marrow megakaryocyte progenitors (CFU-M). Humoral control in vitro. Cell Tissue Kinet. 14: 53, 1981.

    PubMed  CAS  Google Scholar 

  33. Paulus JM, Prenant M, Deschamps JF, Henry-Amar M, Polyploid megakaryocytes develop randomly from a multicompartmental system of committed progenitors. Proc. nat. Acad. Sci. USA, 79: 4410, 1982.

    Article  PubMed  CAS  Google Scholar 

  34. Fausser AA, Messner HA, Identification of megakaryocytes, macrophages and eosinophils in colonies of human bone marrow containing neutrophilic granulocytic and erythroblasts. Blood 53: 1023, 1979.

    Google Scholar 

  35. Vainchenker W, Chapman J, Deschamps JF, Vinci G, Bouquet J, Titeux M, Breton-Gorius J, Normal human serum contains a factor(s) capable of inhibiting megakaryocyte colony formation. Exp. Hemat. 10: 650, 1982.

    PubMed  CAS  Google Scholar 

  36. Messner HA, Jamal N, Izaguirre C, The growth of large megakaryocyte colonies from human bone marrow. J. Cell. Physiol. 45 (suppl. I), 1982.

    Google Scholar 

  37. Vainchenker W, Bouquet J, Guichard J, Breton-Gorius J, Megakaryocyte colony formation from human bone marrow precursors. Blood 54: 940, 1979.

    PubMed  CAS  Google Scholar 

  38. Mazur E, Hoffman R, Bruno E, Regulation of human megakaryocytopoiesis. An in vitro analysis. J. clin. Invest. 68: 733, 1981.

    Article  PubMed  CAS  Google Scholar 

  39. Hoffman R, Mazur E, Bruno E, Floyd V, Assay of an activity in the serum of patients with disorders of thrombopoiesis that stimulates formation of megakaryocytic colonies. New Engl. J. Med. 305: 533, 1981.

    CAS  Google Scholar 

  40. Enomoto K, Kawakita M, Kishimoto S, Katayama N, Miyake T, Thrombopoiesis and megakaryocyte colony stimulating factor in the urine of patients with aplastic anaemia. Brit. J. Haemat. 45: 551, 1980.

    Article  PubMed  CAS  Google Scholar 

  41. Williams N, McDonald TP, Rabellino EM, Maturation and regulation of megakaryocytopoiesis. Blood Cells 5: 43, 1979.

    PubMed  CAS  Google Scholar 

  42. Levin J, Levin FC, Hull III DF, Penington DG, The effects of thrambopoietin on megakaryocyte-CFC, megakaryocytes, and thrombopoiesis with studies of ploidy and platelet size. Blood 60: 989, 1982.

    PubMed  CAS  Google Scholar 

  43. Williams N, Jackson H, Ralph F, Nakoinz I, Cell interactions influencing murine marrow megakaryopoiesis. Nature of the potentiator cell in bone marrow. Blood 57: 157, 1981.

    PubMed  CAS  Google Scholar 

  44. Williams N, Eger RR, Jackson HM, Nelson DJ, Two factor requirement for murine megakaryocyte colony formation. J. Cell. Physiol. 110: 101, 1982.

    Article  PubMed  CAS  Google Scholar 

  45. Vainchenker W, Testa U, Deschamps JF, Henri A, Titeux M, Breton-Gorius J, Rochant H, Lee D, Cartron JP, Clonal expression of the Tn antigen in erythroid and granulocyte colonies and its application to determination of the clonality of the human megakaryocyte colony assay. J. clin. Invest. 69: 1081, 1982.

    Article  PubMed  CAS  Google Scholar 

  46. Johnson GR, Metcalf D, Pure and mixed erythroid colony formation in vitro stimulated by spleen conditioned medium with no detectable erythropoietin. Proc. nat. Acad. Sci. USA, 74: 3879, 1977.

    Article  PubMed  CAS  Google Scholar 

  47. Nakahata T, Ogawa M, Clonal origin of murine hemopoietic colonies with apparent restriction to granulocyte-macrophage-megakaryocyte. (GMM) differentiation. J. Cell. Physiol. 111: 239, 1982.

    Article  PubMed  CAS  Google Scholar 

  48. Burstein SA, Erb SK, Adamson JW, Harker L, Immunologic stimulation of early murine haematopoiesis and its abrogation by cyclosporin. A. Blood 59: 851, 1982.

    CAS  Google Scholar 

  49. Levene RB, Daniel Lamaziere JM, Rabellino EM, Nachman RL, Leung LLK, Phenotypic analysis of human megakaryocyte progenitors. Blood 60: 108 (suppl 1), 1982.

    Google Scholar 

  50. Hoffman R, Bruno E, Elwell J, Mazur E, Gewirtz AM, Dekker P, Dene AE, Acquired a megakaryocytic thrombocytopenic purpura. A syndrome of diverse etiologies. Blood 60: 1173, 1982.

    PubMed  CAS  Google Scholar 

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Authors
  1. J. Breton-Gorius
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  2. W. Vainchenker
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Max R. Hardeman PhD

  2. Department of Nuclear Medicine, Hôpital Saint Louis, Paris, France

    Yves Najean MD

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© 1984 Martinus Nijhoff Publishers, The Hague

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Breton-Gorius, J., Vainchenker, W. (1984). Megakaryocytic Precursors. In: Hardeman, M.R., Najean, Y. (eds) Blood cells in nuclear medicine, part I. Developments in Nuclear Medicine, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6027-5_6

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  • DOI: https://doi.org/10.1007/978-94-009-6027-5_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6029-9

  • Online ISBN: 978-94-009-6027-5

  • eBook Packages: Springer Book Archive

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