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Beta-Thromboglobulin, Present State of the Art

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Blood cells in nuclear medicine, part I

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 6))

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Abstract

The quantification of the platelet contribution to different pathophysiological conditions has always presented problems. This can now be more easily achieved following recent advances that have led to the development of new techniques. Although there are many techniques for measuring platelet behaviour in vitro e.g. aggregation, adhesion etc. It remains uncertain how such activity relates to their function in vivo. Furthermore, the necessity to quantify the platelet contribution to various disease states has become more acute with the development of antiplatelet drugs.

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References

  1. Ludlam CA, Anderton JL, Platelet B-thromboglobulin: Platelet function testing. Day HJ, Holmsen H, Zucker MB (eds), U.S. Dept. of Health, Education and Welfare. Publ. Hlth Serv. Nat. Inst. Health, pp 267–293, 1976.

    Google Scholar 

  2. Ludlam CA, Cash JD, Studies on the liberation of B-thromboglobulin from human platelets in vitro. Brit. J. Haemat. 33: 239, 1976.

    Article  PubMed  CAS  Google Scholar 

  3. Ludlam CA, Moore S, Bolton AE, Pepper DS, Cash JD, The release of a platelet specific protein measured by a radioimmunoassay. Thromb. Res. 6: 543, 1975.

    Article  PubMed  CAS  Google Scholar 

  4. Ludlam CA, Evidence for the platelet specificity of B-thromboglobulin and studies on its plasma concentration in health individuals. Brit. J. Haemat. 41: 271, 1979.

    Article  PubMed  CAS  Google Scholar 

  5. Kaplan KL, B-thromboglobulin. Progress in Haemostasis and Thrombosis 5. pp 153–178, 1980.

    CAS  Google Scholar 

  6. Zahavi J, Kakkar W, B-thromboglobulin: A specific marker of in-vivo platelet release reaction. Thrombos. Haemost. 44: 23, 1980.

    CAS  Google Scholar 

  7. McLaren KM, Holloway L, Pepper DS, Human platelet factor 4 and tissue mast cells. Thromb. Res. 19: 293, 1980.

    Article  PubMed  CAS  Google Scholar 

  8. Dawes J, Smith RC, Pepper DS, The release, distribution and clearance of human B-thromboglobulin and platelet factor 4. Thromb. Res. 12: 851, 1978.

    Article  PubMed  CAS  Google Scholar 

  9. Conley LC, Hartman RC, Lalley JS, The relationship of heparin activity to platelet concentration. Proc. Soc. for Exp. Biol. and Med. 69: 284, 1948.

    CAS  Google Scholar 

  10. Deuel TF, Senior RM, Chang D, Griffin GL, Heinrikson RL, Kaiser ET, Platelet factor 4 is chemotactic for neutrophils and monocytes. Proc. Nat. Acad. Sci. USA 78: 4584, 1981.

    Article  PubMed  CAS  Google Scholar 

  11. Begg GS, Pepper DS, Chesterman CN, Morgan FJ, Complete covalent structure of human B-thromboglobulin. Amer. Chem. Soc. 17: 1739, 1978.

    CAS  Google Scholar 

  12. Niewiarowski S, Walz DA, James P, Rucinski B, Kueppers F, Identification and separation of secreted platelet proteins by isoelectric focusing. Evidence that low-affinity platelet factor 4 is converted to B-thromboglobulin by limited proteolysis. Blood 55: 453, 1980.

    PubMed  CAS  Google Scholar 

  13. Hope W, Martin TJ, Chesterman CN, Morgan FJ, Human B-thromboglobulin inhibits PGI2 production and binds to a specific site in bovine aortic endothelial cells. Nature 282: 210, 1979.

    Article  PubMed  CAS  Google Scholar 

  14. Ager A, Gordon JL, Influe.-nce of human B-thromboglobulin on prostaglandin production by pig aortic endothelial cells in culture. Thromb. Res. 24: 95, 1981.

    Article  PubMed  CAS  Google Scholar 

  15. Levine SP, Lindenfield J, Ellis JB, Raymond NM, Krentz LS, Increased plasma concentrations of platelet factor 4 in coronary artery disease. Circulation 64: 626, 1981.

    Article  PubMed  CAS  Google Scholar 

  16. Kaplan KL, Noseel HL, Drillings M, Leszink G, Radioimmunoassay of PF4 and B-thromboglobulin: Development and application to studies of platelet release in relation to fibrinopeptide A generation. Brit. J. Haemat. 39: 129, 1978.

    Article  PubMed  CAS  Google Scholar 

  17. Handin RI, McDonough M, Lesch M, Elevation of PF4 in acute myocardial function: Measurement by radioimnunoassay. J. Lab, clin. Med. 91: 340, 1978.

    CAS  Google Scholar 

  18. Files JC, Malpass TW, Yee EK, Ritchie JL, Harker LA, Studies of human platelet a-granule release in vivo. Blood 58: 607, 1981.

    PubMed  CAS  Google Scholar 

  19. Franchi F, Canciani MT, Mannuci PM, The B-thromboglobulin test. Thrombos. Haemost. 44: 107, 1980.

    CAS  Google Scholar 

  20. Randi ML, Fabris F, Casonato A, Girolami A, The effect of anticoagulant mixtures on Btg and PF4 levels. Thrombos. Haemost. 46: 569, 1981.

    CAS  Google Scholar 

  21. Wolf P, The nature and significance of platelet products in human plasma. Brit. J. Haemat. 13: 269, 1967.

    Article  PubMed  CAS  Google Scholar 

  22. Dewar HA, Marshall T, Weightman D, Prakash V, Boon PJ, B-thromboglobulin in antecubital vein blood: The influence of age, sex and blood-group. Thrombos. Haemost. 42: 1159, 1979.

    CAS  Google Scholar 

  23. Van Hulsteijn H, Van Es A, Bertina R, Bribt E, Plasma B-thromboglobulin and platelet factor 4 in renal failure. Thromb. Res. 24: 175, 1981.

    Article  PubMed  Google Scholar 

  24. Andrassy K, Deppermann D, Ritz E, Koderisch J, Seelig H, Different effects of renal failure on B-thromboglobulin and high affinity platelet factor 4 (HA-PF4) concentrations. Thromb.Res. 18: 469, 1980.

    Article  PubMed  CAS  Google Scholar 

  25. Depperman D, Andrassy K, Seelig H, Ritz E, Post D, Beta-thromboglobulin is elevated in renal failure without thrombosis. Thromb. Res. 17: 63, 1980.

    Article  Google Scholar 

  26. Bolton AE, Cooke ED, Lekhwani CP, Bowcock SA, Urinary B-thromboglobulin levels as a diagnostic marker for postoperative deep vein thrombosis. Thromb. Res. 19: 249, 1980.

    Article  PubMed  CAS  Google Scholar 

  27. De Boer AC, Han P, Turpie AGG, Butt R, Zielinsky A, Genton E, Plasma and urine B-thromboglobulin concentration in patients with deep vein thrombosis. Blood 58: 693, 1981.

    PubMed  Google Scholar 

  28. Kutti J, Safai-Kutti S, Svardsudd K, Swedberg K, Wadenvik H, Plasma levels of platelet factor 4 in patients admitted to a coronary care unit. Scand. J. Haemat. 26: 235, 1981.

    Article  PubMed  CAS  Google Scholar 

  29. Sobel M, Salzman EW, Davies GC, Handin RI, Sweeney J, Plpetz J, Kurland G, Circulating platelet products in unstable angina pectoris. Circulation 63: 300, 1981.

    Article  PubMed  CAS  Google Scholar 

  30. Rasi V, Ikkala E, Torstila I, Plasma B-thromboglobulin in acute myocardial infarction. Thromb. Res. 25: 203, 1982.

    Article  PubMed  CAS  Google Scholar 

  31. Pumphrey CW, Dawes J, Elevation of plasma B-thromboglobulin in patients with prosthetic cardiac valves. Thromb. Res. 22: 147, 1981.

    Article  PubMed  CAS  Google Scholar 

  32. Cella G, Schivazappa L, Casonato A, Molaro LG, Girolami A, Westwick J, Lane DA, Kakkar W, In vivo platelet release reaction in patients with heart valve prosthesis. Haemostasis 9:263, 1980.

    Google Scholar 

  33. Matthews JH, O’Connor JF, Hearnshaw JR, Wood JK, B-thrunboglobulin and glycosylated haemoglobin in diabetes mellitus. Scand. J. Haemat. 23: 421, 1979.

    Article  PubMed  CAS  Google Scholar 

  34. Betteridge DJ, Zahavi J, Jones NAG, Shine B, Kakkar W, Galton DJ, Platelet function in diabetes mellitus in relationship to complications glycosylated haemoglobin and serum lipoproteins. Eur. J. Clin. Invest. 11: 273, 1981.

    Article  PubMed  CAS  Google Scholar 

  35. Preston FE, Marcola BH, Ward JD, Porter NR, Timperley WR, Elevated B-thromboglobulin levels and circulating platelet aggregates in diabetic microangiopathy. Lancet 1: 238, 1981.

    Google Scholar 

  36. Borsey DQ, Dawes J, Fraser DM, Prowse CV, Elton RA, Clark BF, B-thromboglobulin in diabetes mellitus. Diabetologia 18: 353, 1980.

    PubMed  CAS  Google Scholar 

  37. Elving LD, Casparie AF, Miedema K, Russchen CJ, Plasma B-thromboglobulin in diabetics with and without microangiopathic complications. Diabetologia 21: 160, 1981.

    Article  PubMed  CAS  Google Scholar 

  38. Fabris F, Casonato A, Randi ML, Girolami A, Plasma and platelet B-thromboglobulin levels in patients with May-Hegglin anomaly. Haemosthasis 9: 126, 1980.

    CAS  Google Scholar 

  39. Levy-Toledano S, Caen JP, Breton-Gorius J, Rendu F, Cywiner-Golenzer C, Dupuy E, Legrand Y, Maclouf J, Gray platelet syndrome: a granula deficiency. J. Lab. clin. Med. 98: 831, 1981.

    PubMed  CAS  Google Scholar 

  40. Han P, Turpie AGG, Genton E, Plasma B-thromboglobulin: Differentiation between intravascular and extravascular platelet destruction. Blood 54: 1192, 1979.

    PubMed  CAS  Google Scholar 

  41. Boughton BJ, Corbett WEN, Ginsburg AD, Myeloproliferative disorders: A paradox of in vivo and in vitro platelet function. J. clin. Path. 30: 228, 1977.

    Article  PubMed  CAS  Google Scholar 

  42. Cortelazzo S, Viero P, Barbui T, Platelet activation in myeloproliferative disorders. Thrombos. Haemost. 45: 211, 1981.

    CAS  Google Scholar 

  43. Pareti FI, Gugliotta L, Mannucci L, Guarini A, Mannucci PM, Biochemical and metabolic aspects of platelet dysfunction in chronic myeloproliferative disorders. Thrombos. Haemost. 47: 84, 1982.

    CAS  Google Scholar 

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Authors
  1. C. A. Ludlam
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Editors and Affiliations

  1. Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Max R. Hardeman PhD

  2. Department of Nuclear Medicine, Hôpital Saint Louis, Paris, France

    Yves Najean MD

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© 1984 Martinus Nijhoff Publishers, The Hague

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Ludlam, C.A. (1984). Beta-Thromboglobulin, Present State of the Art. In: Hardeman, M.R., Najean, Y. (eds) Blood cells in nuclear medicine, part I. Developments in Nuclear Medicine, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6027-5_22

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  • DOI: https://doi.org/10.1007/978-94-009-6027-5_22

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6029-9

  • Online ISBN: 978-94-009-6027-5

  • eBook Packages: Springer Book Archive

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