Abstract
Blood platelets play a key role in haemostasis, thrombosis and in all probability in atherosclerosis. Labelling autologous blood platelets with 111In by means of complexing 111In with the lipid soluble compound oxine makes it possible after reinjection of the platelets to study their in-vivo role in atherosclerosis and thrombosis by means of a gamma camera. In the human, 111In-oxine is bound to the cytoplasm of the platelet when the label is brought together with a platelet suspension. So even after release of alpha granulae and dense bodies from the platelets a positive 111In labelled platelet scan can theoretically still be obtained. It is clear that for a positive scan a certain minimal amount of 111In labelled platelets is necessary. The role of blood platelets in different thrombi (e.g. venous, arterial and in aneurysms) is different. At forehand, therefore, it can be anticipated that the contribution of the blood platelet scan for the study of the pathogenesis of thrombosis in those different thrombi is not the same.
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© 1984 Martinus Nijhoff Publishers, The Hague
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Vreeken, J., Hardeman, M.R., Vosmaer, G.D.C., Van Royen, E.A., Van Der Schoot, J.B., Düren, D.R. (1984). Use of 111In-Labelled Platelets in Cardiovascular Disease. In: Hardeman, M.R., Najean, Y. (eds) Blood cells in nuclear medicine, part I. Developments in Nuclear Medicine, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6027-5_19
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DOI: https://doi.org/10.1007/978-94-009-6027-5_19
Publisher Name: Springer, Dordrecht
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