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Current Concepts in Regional Anaesthesia pp 219–225Cite as

Analgesic and Respiratory Effects of Subcutaneous and Epidurally Administered Morphine in Rats

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Part of the book series: Developments in Critical Care Medicine and Anaesthesiology ((DCCA,volume 7))

Summary

The experiments presented here examined the in vivo analgesic and respiratory effects of morphine after epidural and subcutaneous administration in rats.

Both subcutaneous and epidural injections of morphine exerted dose-dependentanalgesic effects. Analgesic effects measured in the tail flick test were biphasic. Both subcutaneous and epidural morphine produced dose-dependent respiratory depressant effects expressed by a decrease in the slope of the carbondioxide response curve.

Respiratory depression at the time of analgesic peak effect at equi-analgesic dosages of morphine was more pronounced after subcutaneous administration than after epidural adnministration.

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Authors
  1. Rob H. W. M. Van Den Hoogen
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Editor information

Editors and Affiliations

  1. Department of Anaesthesiology, Leiden University Hospital, Leiden, The Netherlands

    Jack W. Van Kleef Md , Anton G. L. Burm Msc  & Johan Spierdijk Md ,  & 

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© 1984 Martinus Nijhoff Publishers, The Hague

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Van Den Hoogen, R.H.W.M. (1984). Analgesic and Respiratory Effects of Subcutaneous and Epidurally Administered Morphine in Rats. In: Van Kleef, J.W., Burm, A.G.L., Spierdijk, J. (eds) Current Concepts in Regional Anaesthesia. Developments in Critical Care Medicine and Anaesthesiology, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6015-2_24

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  • DOI: https://doi.org/10.1007/978-94-009-6015-2_24

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6017-6

  • Online ISBN: 978-94-009-6015-2

  • eBook Packages: Springer Book Archive

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