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Some Perspectives on the Hormone-stimulated Adenylate Cyclase System

  • Chapter
Membrane Receptors

Part of the book series: Receptors and Recognition ((WOCS))

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Abstract

A central question in biology concerns how regulation of cellular processes is achieved. A major aspect of this relates to the mechanism by which extracellular factors, e.g., growth factors, neurotransmitters, and hormones, exert their effects. These agents modify the intracellular status of the cell, affecting either a broad range of cell types (e.g. growth hormones) or a more restricted population (e.g. ACTH). A further characteristic is the time span within which the effects become apparent which may be long (e.g. NGF), short (e.g. cAMP generation) or both long and short (e.g. insulin effect on growth and glucose transport). An even more rapid effect is detected with those agents which seem to modulate ion-fluxes (e.g. acetyl- choline). The cell can thus show a very broad time-spectrum of responses. Long term action is believed to reflect a pleiotropic action at the level of the genome (e.g. transcription, translation, and cell division), whereas the short term effects seem to be specific alterations designed to meet particular environmental needs (e.g. cAMP production leading to glycogenolysis). This represents coarse and fine tuning of cellular metabolism, allowing the cell to efficiently co-ordinate adaptations to changing environmental conditions.

Authors’ names are arrange in alphabetical order.

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Schmitges, C.J., Hebdon, G.M., Le Vine, H., Sahyoun, N.E., Cuatrecasas, P. (1981). Some Perspectives on the Hormone-stimulated Adenylate Cyclase System. In: Jacobs, S., Cuatrecasas, P. (eds) Membrane Receptors. Receptors and Recognition. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5866-1_8

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