Abstract
A central question in biology concerns how regulation of cellular processes is achieved. A major aspect of this relates to the mechanism by which extracellular factors, e.g., growth factors, neurotransmitters, and hormones, exert their effects. These agents modify the intracellular status of the cell, affecting either a broad range of cell types (e.g. growth hormones) or a more restricted population (e.g. ACTH). A further characteristic is the time span within which the effects become apparent which may be long (e.g. NGF), short (e.g. cAMP generation) or both long and short (e.g. insulin effect on growth and glucose transport). An even more rapid effect is detected with those agents which seem to modulate ion-fluxes (e.g. acetyl- choline). The cell can thus show a very broad time-spectrum of responses. Long term action is believed to reflect a pleiotropic action at the level of the genome (e.g. transcription, translation, and cell division), whereas the short term effects seem to be specific alterations designed to meet particular environmental needs (e.g. cAMP production leading to glycogenolysis). This represents coarse and fine tuning of cellular metabolism, allowing the cell to efficiently co-ordinate adaptations to changing environmental conditions.
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References
Bakardjieva, A., Galla, H.J. and Helmreich, E.J.M. (1979), Biochemistry, 18, 3016–3023
Bennett, V. and Stenbuck, P. (1979a), J. biol. Chem., 254, 2533–2541
Bennett, V. and Stenbuck, P. (1979b), Nature, 280, 468–473
Bennett, V. (1979), Nature, 281, 597–599
Bennett, V. and Cuatrecasas, P. (1976), In: The Specificity and Action of Animal, Bacterial and Plant Toxins, Receptors and Recognition (Cuatrecasas, P., ed.), Series B, Vol. 1, pp. 1–66, Chapman and Hall, London.
Bird, S.J. and Maguire, M.E. (1978), J. biol. Chem., 253, 8826–8834
Bonnafous, J.-C., Dornand, J. and Mani, J.-C. (1979), FEBS Letters, 99, 152–156
Bourne, H.R., Coffino, P. and Tomkins, G.M. (1975), Science, 187, 750–752
Bradham, L.S. (1977), J. cyc. nucleot. Res., 3, 119–128
Braun, T. and Dods, R.F. (1975), Proc. natn. Acad. Sci. U.S.A., 72, 1097–1101
Cassel, D., Eckstein, F., Lowe, M. and Selinger, Z. (1979), J. biol. Chem., 254, 9835–9838
Cassel, D., Levkovitz, H. and Selinger, Z. (1977), J. cyc. nucleot. Res., 3, 393–406
Cassel, D. and Pfeuffer, T. (1978), Proc. natn. Acad. Sci. U.S.A., 75, 2669–2673
Cassel, D. and Selinger, Z. (1976), Biochim. biophys. Acta, 452, 538–551
Cassel, D. and Selinger, Z. (1977), Proc. natn. Acad. Sci. U.S.A., 74, 3307–3311
Cassel, D. and Selinger, Z. (1978), Proc. natn. Acad. Sci. U.S.A., 75, 4155–4159
Catt, K.J., Harwood, J.P., Aguilera, G. and Dufau, M.L. (1979), Nature, 280, 109–116
Coleman, R. (1973), Biochim. biophys. Acta, 300, 1–30
Crews, F.T., Morita, Y., Hirata, F. and Axelrod, J. (1980), Biochem. biophys. Res. Comm., 93, 42–49
Cuatrecasas, P. (1974), Ann. Rev. Biochem., 43, 169–214
Cuatrecasas, P., Jacobs, S. and Bennett, G.V. (1975), Proc. natn. Acad. Sci. U.S.A., 72, 1739–1743
Daniel, V., Litwack, G. and Tomkins, G.M. (1973), Proc. natn. Acad. Sci. U.S.A., 70, 76–79
Davoust, J., Bienvenue, A., Felliman, P. and Devaux, P.F. (1980), Biochim. biophys. Acta., 596, 28–42
Dipple, I. and Houslay, M.D. (1978), Biochem. J., 174, 179–190
Drummond, G.I., Sano, M. and Nambi, P. (1980), Arch, biochem. biophys., 201, 286–295
Dufau, M.L., Hayashi, K., Sala, G., Bankal, A. and Catt, K.J. (1978), Proc. natn. Acad. Sci. U.S.A., 75, 4769–4773
Dullis, B.H. and Wilson, I.B. (1980), J. biol. Chem., 255, 1043–1048
Eimerl, S., Neufeld, G., Korner, M. and Schramm, M. (1980), Proc. natn. Acad. Sci. U.S.A., 77, 760–764
Engelhard, V.H., Esko, J.D., Storm, D.R. and Glaser, M. (1976), Proc. natn. Acad. Sci. U.S.A., 73, 4482–4486
Engelhard, V.H., Glaser, M. and Storm, D.R. (1978), Biochemistry, 17, 3191–3200
Enomoto, K. and Gill, D.M. (1979), J. supramol. Struct., 10, 51–60
Farfel, Z., Kaslow, H.R. and Bourne, H.R. (1979), Biochem. biophys. Res. Comm., 90, 1237–1241
Fox, C.F. and Das, M. (1979), J. supramol. Structure, 10, 199–214
Ganguly, U. and Greenough, III, W.B. (1975), Proc. natn. Acad. Sci. U.S.A., 72, 3561–3564
Gemsa, D., Steggemann, L., Till, G. and Resch, K. (1977), J. Immunol., 119, 524–529
Gill, D.M. (1976), J. Infectious Dis., 133, S55–S63.
Gill, D.M. (1977), Adv. cyc. nucleot. Res., 8, 85–118
Gill, D.M. and King, C.A. (1975), J. biol. Chem., 250, 6424–6432
Gill, D.M. and Meren, R. (1978), Proc. natn. Acad. Sci U.S.A., 75, 3050–3054
Glaser, M., Ferguson, K.A. and Vagelos, P.R. (1974), Proc. natn. Acad. Sci. U.S.A., 71, 4072–4076.
Goldstein, J.L., Anderson, R.G.W. and Brown, M.S. (1979), Nature, 279, 679–685
Grollman, E.F., Lee, G., Ambesi-Impiombato, F.S., Meldolesi, M.F., Aloj, S.M., Coon, H.G., Kaback, H.R. and Kohn, L.D. (1977), Proc. natn. Acad. Sci. U.S.A., 74, 2352–2356
Guillon, G., Couraud, P.O. and Roy, C. (1979), Biochem. biophys. Res. Comm., 87, 855–861.
Haga, T., Haga, K. and Gilman, A.G. (1977a), J. biol. Chem., 251, 5776–5782
Haga, T., Ross, E.M., Anderson, H.J. and Gilman, A.G. (1977b), Proc. natn. Acad. Sci. U.S.A., 74, 2016–2020.
Hagmann, J. and Fishman, P.H. (1980), J. biol. Chem., 255, 2659–2662
Hebdon, G.M., LeVine, III, H., Minard, R.B., Sahyoun, N.E., Schmitges, C.J. and Cuatrecasas, P. (1979), J. biol. Chem., 254, 10459–10465
Hebdon, G.M., LeVine, III, H., Sahyoun, N.E., Schmitges, C.J. and Cuatrecasas, P. (1978), Proc. natn. Acad. Sci. U.S.A., 75, 3693–3697
Hesketh, T.R., Smith, G.A., Houslay, M.D., McGill, K.A., Birdsall, N.J.M., Metcalfe, J.C. and Warren, G.B. (1976), Biochemistry, 15, 4145–4151
Hirata, F. and Axelrod, J. (1978a), Nature, 275, 219–220
Hirata, F. and Axelrod, J. (1978b), Proc. natn. Acad. Sci U.S.A., 75, 2348–2352
Hirata, F., Axelrod, J. and Crews, F.T. (1979a), Proc. natn. Acad. Sci U.S.A., 76, 4813–4816.
Hirata, F., Corcoran, B.A., Venkatasubramanian, K., Schiffman, E. and Axelrod, J. (1979b), Proc. natn. Acad. Sci U.S.A., 76, 368–372
Hirata, F., Corcoran, B.A., Venkatasubramanian, K., Schiffman, E. and Axelrod, J. (1979c), Proc. natn. Acad. Sci U.S.A., 76, 2640–2643
Hirata, F., Strittmatter, W.J. and Axelrod, J. (1979a), Proc. natn. Acad. Sci U.S.A., 76, 368–372
Hirata, F., Toyoshima, S., Axelrod, J. and Waxdal, M.J. (1980), Proc. natn. Acad. Sci U.S.A., 77, 862–865
Hirata, F., Viveros, O.H., Diliberto, E.M., Jr. and Axelrod, J. (1978), Proc. natn. Acad. Sci U.S.A., 75, 1718–1721
Hoffman, F.M. (1979a), J. biol. Chem., 254, 255–258
Hoffman, F.M. (1979b), Biochem. biophys. Res. Comm., 86, 988–994
Houslay, M.D., Ellory, J.C., Smith, G.A., Hesketh, T.R., Stein, J.M., Warren, G.B. and Metcalfe, J.C. (1977), Biochim. biophys. Acta, 467, 208–219
Houslay, M.D., Hesketh, T.R., Smith, G.A., Warren, G.B. and Metcalfe, J.C. (1976), Biochim. biophys. Acta, 436, 495–504
Houslay, M.D. and Palmer, R.W. (1979), Biochem. J., 178, 217–221
Howlett, A.C., Sternweis, P.C., Macik, B.A., Van Arsdale, P.M. and Gilman, A.G. (1979), J. biol. Chem., 254, 2287–2295
Insel, P.A., Bourne, H.R., Coffino, P. and Tomkins, G.M. (1975), Science, 190, 896–898
Insel, P.A., Maguire, M.E., Gilman, A.G., Bourne, H.R., Coffino, P. and Melmon, K.L. (1976), Mol Pharmacol., 12, 1062–1068
Ishizaka, T., Hirata, F., Ishizaka, K. and Axelrod, J. (1980), Proc. natn. Acad. Sci. U.S.A., 77, 1903–1906
Ito, A. and Sato, R. (1968), J. Biol. Chem., 243, 4922–4923
Jacobs, S. and Cuatrecasas, P. (1976), J. cyc. nucleot. Res., 2, 205–223
Johnson, G.L., Bourne, H.R., Gleason, M.K., Coffino, P., Insel, P.A. and Melmon, K.L. (1979), Mol. Pharmacol., 15, 16–27
Johnson, G.L., Kaslow, H.R. and Bourne, H.R. (1978b), J. biol. Chem., 253, 7120–7123
Johnson, G.L., Kaslow, H.R. and Bourne, H.R. (1978a), Proc. natn. Acad. Sci. U.S.A., 75, 3113–3117.
Johnson, R.A. and Sutherland, E.W. (1973), J. biol. Chem., 248, 5114–5121
Kaslow, H.R., Farfel, Z., Johnson, G.L. and Bourne, H.R. (1979), Mol. Pharmacol., 15, 472–483.
Katz, M.S., Kelly, T.M., Pineyro, M.A. and Gregerman, R.I. (1978), J. cyc. nucleot. Res., 5, 389–407
Kennedy, M.S. and Insel, P.A. (1979), Mol. Pharmacol., 16, 215–223
Kurokawa, T., Kurokawa, M. and Ishibashi, S. (1979), Biochim. biophys. Acta, 583, 467–473
Laburthe, M., Rosselin, G., Rousset, M., Zweibaum, A., Korner, M., Selinger, Z. and Schramm, M. (1979), FEBS Letters, 98, 41–43
Lad, P.M., Nielsen, T.B., Preston, M.S. and Rodbell, M. (1980), J. biol. Chem., 255, 988–995
Lad, P.M., Preston, S., Welton, A.F., Nielsen, T.B. and Rodbell, M. (1979), Biochim. biophys. Acta, 551, 368–381
Leavitt, W.W. and Clark, J.H., eds. (1979), Steroid Hormone Receptor Systems, Plenum Press, New York.
Levey, G.S. (1973), Rec. Progr. Hormone Res., 29, 361–382
Le Vine, III, H. and Cuatrecasas, P. (1980a), (manuscript submitted).
Le Vine, III, H. and Cuatrecasas, P. (1980b) J. Pharmacol Therap. In press.
Limbird, L.E., Hickey, A.R. and Lefkowitz, R.J. (1979), J. cyc. nucleot. Res., 5, 251–259
Limbird, L.E. and Lefkowitz, R.J. (1975), Mol. Pharmacol., 12, 559–567
Limbird, L.E. and Lefkowitz, R.J. (1977), J. biol. Chem., 252, 799–802
Londos, C., Salomon, Y., Lin, M.C., Harwood, J.P., Schramm, M., Wolfe, J. and Rodbell, M. (1977), Proc. natn. Acad. Sci. U.S.A., 71, 3087–3090
Lux, S.E. (1979), Nature, 281, 426–429
Maguire, M.E. and Erdos, J.J. (1978), J. biol. Chem., 253, 6633–6636
Maguire, M.E. and Erdos, J.J. (1980), J. biol. Chem., 255, 1030–1035
Maguire, M.E., Ross, E.M. and Gilman, A.G. (1977), Adv. cyc. nucleot. Res., 8, 1–83
Martin, B.R., Stein, J.M., Kennedy, E.L., Doberska, C.A. and Metcalfe, J.C. (1979), Biochem. J., 184, 253–260.
Martin, F.J. and Macdonald, R.C. (1976), J. cell Biol., 70, 515–526
Monneron, A. and d’Alayer, J. (1980), FEBS Letters, 109, 75–80
Naya-Vigne, J., Johnson, G.L., Bourne, H.R. and Coffino, P. (1978), Nature, 272, 720–722
Orly, J. and Schramm, M. (1976), Proc. natn. Acad. Sci. U.S.A., 73, 4410–4414
Pecker, F. and Hanoune, J. (1977a), FEBS Letters, 83, 93–98
Pecker, F. and Hanoune, J. (1977b), J. biol. Chem., 252, 2784–2786
Pfeuffer, T. (1977), J. biol. Chem., 252, 7224–7234
Pfeuffer, T. (1979), FEBS Letters, 101, 85–89
Pfeuffer, T. and Helmreich, E.J.M. (1975), J. biol. Chem., 250, 867–876
Puchwein, G., Pfeuffer, T. and Helmreich, E.J.M. (1974), J. biol. Chem., 249, 3232–3240
Renart, M.F., Ayanoglu, G., Mansour, J.M. and Mansour, T.E. (1979), Biochem. biophys. Res. Comm., 89, 1146–1153
Rethy, A., Tomasi, V., Trevisani, A. and Barnobei, O. (1972), Biochim. biophys. Acta, 290, 58–69
Rimon, G., Hanski, E., Braun, S. and Levitzki, A. (1978), Nature, 276 396-399.
Robinson, N.C. and Tanford, C. (1975), Biochemistry, 14, 369–378
Rodbell, M. (1980), Nature, 284, 17–22
Rodbell, M., Birnbaumer, L., Pohl, S.L. and Krans, H.M.J. (1971), J. biol. Chem., 246, 1877–1882
Rodbell, M., Lin, M.C., Salomon, Y., Londos, C., Harwood, J.P., Martin, B.R., Rendell, M. and Berman, M. (1975), Adv. cyc. nucleot. Res., 5, 3–29
Ross, E.M. and Gilman, A.G. (1977a), Proc. natn. Acad. Sci. U.S.A., 74, 3715–3719
Ross, E.M. and Gilman, A.G. (1977b), J. biol. Chem., 252, 6966–6969
Ross, E.M., Howlett, A.C., Ferguson, K.M. and Gilman, A.G. (1978), J. biol. Chem., 253, 6401–6412.
Ross, E.M., Maguire, M.E., Sturgill, T.W., Biltonen, R.L. and Gilman, A.G. (1977), J. biol. Chem., 252, 5761–5775
Rubalcava, B. and Rodbell, M. (1973), J. biol. Chem., 248, 3831–3837
Rudolph, S.A., Greengard, P. and Malawista, S.E. (1977), Proc. natn. Acad. Sci. U.S.A., 74, 3404–3408
Sahyoun, N.E., Schmitges, C.J., LeVine, III, H. and Cuatrecasas, P. (1977), Life Sciences, 21, 1857–1864
Sandermann, H. (1978), Biochim. biophys. Acta, 515, 209–237
Sanders, R.B., Thompson, W.J. and Robison, G.A. (1977), Biochim. biophys. Acta, 498, 10–20
Sano, K., Katsuda, K. and Maeno, H. (1978), Neurochem. Res., 3, 674.
Sano, K., Nishikori, K., Noshiro, O. and Maeno, H. (1979), Arch, biochem. Biophys., 197, 285–293
Schlegel, W., Kempner, E.S. and Rodbell, M. (1979), J. biol. Chem., 254, 5168–5176
Schramm, M. (1979), Proc. natn. Acad. Sci. U.S.A., 76, 1174–1178
Schramm, M., Orly, J., Eimerl, S. and Korner, M. (1977), Nature, 268, 310–313
Schramm, M. and Rodbell, M. (1975), J. biol. Chem., 250, 2232–2237
Schulster, D., Orly, J., Seidel, G. and Schramm, M. (1978), J. biol. Chem., 253, 1201–1206
Schwarzmeier, J.D. and Gilman, A.G. (1977), J. cyc. nucleot. Res., 3, 227–238
Shier, W.T., Baldwin, J.H., Nilsen-Hamilton, M., Hamilton, R.T. and Thanassi, N.M. (1976), Proc. natn. Acad. Sci. U.S.A., 73, 1586–1590
Simantov, R. and Sachs, L. (1978), FEBS Letters, 90, 69–75
Sinensky, M., Minneman, P. and Molinoff, P.B. (1979), J. biol. Chem., 254, 9135–9141
Spatz, L. and Strittmatter, P. (1971), Proc. natn. Acad. Sci. U.S.A., 68, 1042–1046
Sternweis, P.C. and Gilman, A.G. (1979), J. biol. Chem., 254, 3333–3340
Strittmatter, W.J., Hirata, F. and Axelrod, J. (1979), Science, 204, 1205–1207
Toscano, Jr., W.A., Wescott, K.R., LaPorte, D.C. and Storm, D.R. (1979), Proc. natn. Acad. Sci. U.S.A., 76, 5582–5586
Tyler, J.M., Hargreaves, W.R. and Branton, D. (1979), Proc. natn. Acad. Sci. U.S.A., 76, 5192–5196
Vaughan, M. and Moss, J. (1978), J. supramol. Struct., 8, 473–488
Wagner, H.R. and Davis, J.N. (1979), Proc. natn. Acad. Sci. U.S.A., 76, 2057–2061
Warren, G.B., Houslay, M.D., Metcalfe, J.C. and Birdsall, N.J.M. (1975), Nature, 225, 684–687
Williams, L.T., Mullikin, D. and Lefkowitz, R.J. (1978), J. biol. Chem., 253, 2984–2989
Zor, U., Strulovici, B. and Lindner, H.R. (1978), Biochem. biophys. Res. Comm., 80, 983–992
Zwiller, J., Ciesielski-Treska, J. and Mandel, P. (1976), FEBS Letters, 69, 286–290
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Schmitges, C.J., Hebdon, G.M., Le Vine, H., Sahyoun, N.E., Cuatrecasas, P. (1981). Some Perspectives on the Hormone-stimulated Adenylate Cyclase System. In: Jacobs, S., Cuatrecasas, P. (eds) Membrane Receptors. Receptors and Recognition. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5866-1_8
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