Abstract
Adherence of bacteria to tissue surfaces has recently gained increasing attention as an important initial event in the pathogenesis of bacterial infections (Ofek and Beachey, 1980). The infectious process in animals and man can be envisioned as a stepwise process in which bacteria must first adhere to a tissue surface. The failure to adhere would result simply in their being swept away in the fluids which constantly bathe the tissue surfaces. Adherence of pathogenic organisms is then followed by colonization and eventual invasion of the surface either by a toxin produced by the colonizing organisms or by the bacteria themselves. In the deeper tissues, the attachment of the bacteria to phagocytic cells results in their ingestion and destruction. Organisms whose surfaces are not recognized by antibody and complement or phagocytic cells can multiply unimpeded to produce systemic infections. These steps in the infectious process are depicted diagramatically in Fig. 1.1.
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Ofek, I., Beachey, E.H. (1980). General Concepts and Principles of Bacterial Adherence in Animals and Man. In: Beachey, E.H. (eds) Bacterial Adherence. Receptors and Recognition, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5863-0_1
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DOI: https://doi.org/10.1007/978-94-009-5863-0_1
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